{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T11:02:09Z","timestamp":1773054129294,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"5b","license":[{"start":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T00:00:00Z","timestamp":1398211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2014,5]]},"abstract":"\n Objective<\/jats:title>\n \n \n \n \n To assess the incidence and clinical significance of \u2018skip lesions\u2019 that are present in proximal but not in distal ureteric sections, which are occasionally found during the pathological examination of ureteric margins during radical cystectomy (\n RC<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n \n \n \n We identified 660 patients who underwent a\n RC<\/jats:styled-content>\n and had at least two permanent margins for a given ureter.\n <\/jats:p>\n <\/jats:list-item>\n \n \n In all, 1173 ureters were analysed and classified as follows: \u2018normal\u2019 (no tumour, reactive atypia, mild or moderate dysplasia) or \u2018abnormal\u2019 (severe dysplasia, carcinoma\n in situ<\/jats:italic>\n (\n CIS<\/jats:styled-content>\n ), or tumour).\n <\/jats:p>\n <\/jats:list-item>\n \n Transitions from \u2018normal\u2019 distal pathology to \u2018abnormal\u2019 on proximal section(s) determined frequency of skip lesions.<\/jats:p>\n <\/jats:list-item>\n \n Fisher's exact test and the log\u2010rank test were used to study correlations.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n \n Ureteric skip lesions were found in 4.8% patients (2.9% ureters).<\/jats:p>\n <\/jats:list-item>\n \n \n Pathology of skip lesions was\n CIS<\/jats:styled-content>\n in 55.9%, transitional cell carcinoma in 23.5% and severe dysplasia in 20.6%.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Skip lesions were associated with lymphovascular invasion (34.4% vs 13.7%,\n P<\/jats:italic>\n = 0.004) and advanced pT stage (\n P<\/jats:italic>\n = 0.007).\n <\/jats:p>\n <\/jats:list-item>\n \n \n On multivariate analysis, skip lesions correlated with lower median overall survival (\n OS<\/jats:styled-content>\n ) (inestimable vs 8.2 years,\n P<\/jats:italic>\n = 0.014) in patients with pT0 or pTa disease and a trend towards lower\n OS<\/jats:styled-content>\n (2.7 vs 8.8 years,\n P<\/jats:italic>\n = 0.066) in pTis disease.\n <\/jats:p>\n <\/jats:list-item>\n \n Concordance between frozen distal margin and permanent proximal margin varied; sensitivity was 80% in those without and 20% in those with skip lesions.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n \n \n The presence of a ureteric skip lesion may be associated with lower survival in patients with pT0, pTa or pTis urothelial carcinoma.<\/jats:p>\n <\/jats:list-item>\n \n Thus, while uncommon, ureteric skip lesions should be reported in pathological findings.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12344","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T10:11:08Z","timestamp":1372759868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical significance of ureteric \u2018skip lesions\u2019 at the time of radical cystectomy: the\n M<\/scp>\n .\n D<\/scp>\n .\n A<\/scp>\n nderson experience and literature review"],"prefix":"10.1111","volume":"113","author":[{"given":"Anthony N.","family":"Hoang","sequence":"first","affiliation":[{"name":"Urologic Oncology Branch National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piyush K.","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Urologic Oncology Branch National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annerleim","family":"Walton\u2010Diaz","sequence":"additional","affiliation":[{"name":"Urologic Oncology Branch National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher G.","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Urology The University of Texas M.D. Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam R.","family":"Metwalli","sequence":"additional","affiliation":[{"name":"Urologic Oncology Branch National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wassim","family":"Kassouf","sequence":"additional","affiliation":[{"name":"Department of Urology The University of Texas M.D. Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon A.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Urology The University of Texas M.D. Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"Black","sequence":"additional","affiliation":[{"name":"Department of Urology The University of Texas M.D. Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana L.","family":"Urbauer","sequence":"additional","affiliation":[{"name":"Division of Quantitative Sciences The University of Texas M.D. Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Barton","family":"Grossman","sequence":"additional","affiliation":[{"name":"Department of Urology The University of Texas M.D. Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin P.N.","family":"Dinney","sequence":"additional","affiliation":[{"name":"Department of Urology The University of Texas M.D. Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish M.","family":"Kamat","sequence":"additional","affiliation":[{"name":"Department of Urology The University of Texas M.D. Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25202"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22238"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-010-0581-z"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.08.158"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(89)90127-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)66223-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)64312-X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000092928"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000049793"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(96)00571-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.07.162"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06567.x"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbju.12344","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.12344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T09:12:04Z","timestamp":1761729124000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.12344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,23]]},"references-count":12,"journal-issue":{"issue":"5b","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/bju.12344"],"URL":"https:\/\/doi.org\/10.1111\/bju.12344","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,23]]},"assertion":[{"value":"2014-04-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}