{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:55:45Z","timestamp":1790621745597,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T00:00:00Z","timestamp":1383177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2014,1]]},"abstract":"\n Objective<\/jats:title>\n \n \n \n \n To define predictors of the deformity stabilisation and improvement in men with untreated\n P<\/jats:styled-content>\n eyronie's disease (\n PD<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n \n \n \n The study population consisted of patients with\n PD<\/jats:styled-content>\n \u2010associated uniplanar curvature, who opted for no treatment and were followed for at least 12 months.\n <\/jats:p>\n <\/jats:list-item>\n \n \n All patients had deformity assessment (\n DA<\/jats:styled-content>\n ) performed on initial presentation and at follow\u2010up. Stabilisation of\n PD<\/jats:styled-content>\n was defined as no change between\n DAs<\/jats:styled-content>\n (\u00b110\u00b0), while improvement and progression were defined as \u226510\u00b0 change.\n <\/jats:p>\n <\/jats:list-item>\n \n Patients were subdivided into different groups based on time to presentation: \u22646 months (A), 7\u201312 months (B), and 13\u201318 months (C).<\/jats:p>\n <\/jats:list-item>\n \n Multivariable analysis was used to define predictors of stabilisation and improvement.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n \n In all, 176 men met the inclusion criteria.<\/jats:p>\n <\/jats:list-item>\n \n \n The mean age was 54 years, with a mean (\n sd<\/jats:sc>\n )\n PD<\/jats:styled-content>\n duration of 9 (12) months and mean curvature of 42 (27)\u00b0.\n <\/jats:p>\n <\/jats:list-item>\n \n \n In all, 67% of the entire population had no change in deformity over time, 12% improved with a mean (\n sd<\/jats:sc>\n ) change of 27 (14)\u00b0, and 21% worsened with a mean (\n sd<\/jats:sc>\n ) change of 22 (11)\u00b0.\n <\/jats:p>\n <\/jats:list-item>\n \n \n On multivariate analysis, predictors of stabilisation included: time to presentation of >6 months (odds ratio [\n OR<\/jats:styled-content>\n ] 2.4,\n P<\/jats:italic>\n < 0.01), per decade increase in age (\n OR<\/jats:styled-content>\n 1.5,\n P<\/jats:italic>\n < 0.05), and age (\n r<\/jats:italic>\n = 0.32,\n P<\/jats:italic>\n < 0.05).\n <\/jats:p>\n <\/jats:list-item>\n \n \n Predictors of improvement included: time to presentation of \u22646 months (\n OR<\/jats:styled-content>\n 4.1,\n P<\/jats:italic>\n < 0.001), and per decade decrease in age (\n OR<\/jats:styled-content>\n 2.1,\n P<\/jats:italic>\n < 0.01).\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n \n \n \n In men with uniplanar curvature,\n PD<\/jats:styled-content>\n stabilisation and improvement rates change with time\u2010to\u2010presentation and patient age.\n <\/jats:p>\n <\/jats:list-item>\n \n \n These data may aid in counselling patients with\n PD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12346","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T10:11:13Z","timestamp":1372759873000},"page":"133-136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Deformity stabilization and improvement in men with untreated\n P<\/scp>\n eyronie's disease"],"prefix":"10.1111","volume":"113","author":[{"given":"Boback M.","family":"Berookhim","sequence":"first","affiliation":[{"name":"Male Sexual and Reproductive Medicine Program Urology Service Department of Surgery Memorial Sloan\u2010Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Choi","sequence":"additional","affiliation":[{"name":"Male Sexual and Reproductive Medicine Program Urology Service Department of Surgery Memorial Sloan\u2010Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byron","family":"Alex","sequence":"additional","affiliation":[{"name":"Male Sexual and Reproductive Medicine Program Urology Service Department of Surgery Memorial Sloan\u2010Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Mulhall","sequence":"additional","affiliation":[{"name":"Male Sexual and Reproductive Medicine Program Urology Service Department of Surgery Memorial Sloan\u2010Kettering Cancer Center New York NY 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