{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T08:34:43Z","timestamp":1782290083621,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T00:00:00Z","timestamp":1383177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30901489"],"award-info":[{"award-number":["30901489"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shanghai Jiaotong University Morningstar Scholars Programme"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2014,7]]},"abstract":"\n Objective<\/jats:title>\n \n \n \n \n To investigate the early and delayed effects of cavernous nerve electrocautery injury (\n CNEI<\/jats:styled-content>\n ) in a rat model, with the expectation that this model could be used to test rehabilitation therapies for erectile dysfunction (\n ED<\/jats:styled-content>\n ) after radical prostatectomy (\n RP<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n \n \n \n In all, 30 male\n S<\/jats:styled-content>\n prague\u2010\n D<\/jats:styled-content>\n awley rats were randomly divided equally into two groups (15 per group). The control group received\n CNs<\/jats:styled-content>\n exposure surgery only and the experimental group received bilateral\n CNEI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:list-item>\n \n \n At 1, 4 and 16 weeks after surgery (five rats at each time point), the ratio of maximal intracavernosal pressure (\n ICP<\/jats:styled-content>\n ) to mean arterial pressure (\n MAP<\/jats:styled-content>\n ) was measured in the two groups. Neurofilament expression in the dorsal penile nerves was assessed by immunofluorescent staining and\n M<\/jats:styled-content>\n asson's trichrome staining was used to assess the smooth muscle to collagen ratio in both groups.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n \n \n At the 1\u2010week follow\u2010up, the mean\n ICP<\/jats:styled-content>\n \/\n MAP<\/jats:styled-content>\n was significantly lower in the\n CNEI<\/jats:styled-content>\n group compared with the control group, at 9.94% vs 70.06% (\n P<\/jats:italic>\n < 0.05).\n <\/jats:p>\n <\/jats:list-item>\n \n \n The mean\n ICP<\/jats:styled-content>\n \/\n MAP<\/jats:styled-content>\n in the\n CNEI<\/jats:styled-content>\n group was substantially increased at the 4\u2010 (35.97%) and 16\u2010week (37.11%) follow\u2010ups compared with the 1\u2010week follow\u2010up (\n P<\/jats:italic>\n < 0.05).\n <\/jats:p>\n <\/jats:list-item>\n \n \n At all three follow\u2010up time points, the\n CNEI<\/jats:styled-content>\n group had significantly decreased neurofilament staining compared with the control group (\n P<\/jats:italic>\n < 0.05). Also, neurofilament expressions in the\n CNEI<\/jats:styled-content>\n group at both 4 and 16 weeks were significantly higher than that at 1 week (\n P<\/jats:italic>\n < 0.05), but there was no difference between 4 and 16 weeks (\n P<\/jats:italic>\n > 0.05).\n <\/jats:p>\n <\/jats:list-item>\n \n \n The smooth muscle to collagen ratio in the\n CNEI<\/jats:styled-content>\n group was significantly lower than in the control group at the 4\u2010 and 16\u2010week follow\u2010ups (\n P<\/jats:italic>\n < 0.05), and the ratio at 16 weeks was further reduced compared with that at 4 weeks (\n P<\/jats:italic>\n < 0.05).\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n \n \n \n In the\n CNEI<\/jats:styled-content>\n rat model, we found the damaging effects of\n CNEI<\/jats:styled-content>\n were accompanied by a decline in\n ICP<\/jats:styled-content>\n , reduced numbers of nerve fibres in the dorsal penile nerve, and exacerbated fibrosis in the corpus cavernosum.\n <\/jats:p>\n <\/jats:list-item>\n \n \n This may provide a basis for studying potential preventative measures or treatment strategies to ameliorate\n ED<\/jats:styled-content>\n caused by\n CNEI<\/jats:styled-content>\n during\n RP<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12348","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T10:11:16Z","timestamp":1372759876000},"page":"133-139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Electrocautery\u2010induced cavernous nerve injury in rats that mimics radical prostatectomy in humans"],"prefix":"10.1111","volume":"114","author":[{"given":"Lu\u2010Jie","family":"Song","sequence":"first","affiliation":[{"name":"Department of Urology Shanghai Sixth People's Hospital Shanghai Jiao Tong University Shanghai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Qiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Urology Weifang Traditional Chinese Medicine Hospital Weifang Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Kai","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai Sixth People's Hospital Shanghai Jiao Tong University Shanghai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Chuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Weifang Traditional Chinese Medicine Hospital Weifang Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Bin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology Shanghai Sixth People's Hospital Shanghai Jiao Tong University Shanghai Shandong 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