{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T20:35:10Z","timestamp":1769718910307,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T00:00:00Z","timestamp":1402012800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2014,6]]},"abstract":"\n Objectives<\/jats:title>\n \n \n \n \n To evaluate the prognostic value of the\n B<\/jats:styled-content>\n ajorin criteria in a multi\u2010institutional cohort of patients with disease recurrence after radical nephroureterectomy (\n RNU<\/jats:styled-content>\n ) for upper tract urothelial carcinoma (\n UTUC<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:list-item>\n \n To investigate whether clinical, pathological and\/or biological factors at time of disease recurrence are also associated with cancer\u2010specific outcomes in these patients.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n \n \n \n We identified 242 patients with disease recurrence after\n RNU<\/jats:styled-content>\n for\n UTUC<\/jats:styled-content>\n from 11 centres.\n <\/jats:p>\n <\/jats:list-item>\n \n \n With regard to the\n B<\/jats:styled-content>\n ajorin criteria, patients were categorized into three groups based on two risk factors:\n K<\/jats:styled-content>\n arnofsky performance status <80% and the presence of visceral metastasis.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Assessed variables included pathological characteristics, time to disease recurrence, age\u2010adjusted\n C<\/jats:styled-content>\n harlson comorbidity index (\n ACCI<\/jats:styled-content>\n ),\n A<\/jats:styled-content>\n merican\n S<\/jats:styled-content>\n ociety of\n A<\/jats:styled-content>\n nesthesiologists (\n ASA<\/jats:styled-content>\n ) score, and laboratory tests at time of disease recurrence.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n \n Overall, 185 patients died from their disease; the median survival was 9 months. The survival rates at 1 year were 53, 33, and 39% for patients with no (n = 18), one (n = 109) and two (n = 115) risk factors, respectively, with no significant difference between the groups.<\/jats:p>\n <\/jats:list-item>\n \n \n In univariable analyses, higher\n pT<\/jats:styled-content>\n \u2010stage, tumour necrosis, non\u2010administered salvage chemotherapy, higher\n ACCI<\/jats:styled-content>\n score, higher\n ASA<\/jats:styled-content>\n score, lower albumin level and higher white blood cell count were significantly associated with a shorter time to cancer\u2010specific mortality.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n \n \n \n We confirmed the poor yet variable outcomes of patients with disease recurrence after\n RNU<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:list-item>\n \n \n While the\n B<\/jats:styled-content>\n ajorin criteria seem to have limited prognostic value in this specific cohort, we found several other clinical variables to be associated with worse cancer\u2010specific mortality.\n <\/jats:p>\n <\/jats:list-item>\n \n If validated, these factors should be taken into consideration for clinical trial design.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12369","type":"journal-article","created":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T05:51:27Z","timestamp":1374213087000},"page":"911-917","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Predictors of survival in patients with disease recurrence after radical nephroureterectomy"],"prefix":"10.1111","volume":"113","author":[{"given":"Luis A.","family":"Kluth","sequence":"first","affiliation":[{"name":"Department of Urology Weill Cornell Medical College New York Presbyterian Hospital New York NY USA"},{"name":"Department of Urology University Medical\u2010Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evanguelos","family":"Xylinas","sequence":"additional","affiliation":[{"name":"Department of Urology Weill Cornell Medical College New York Presbyterian Hospital New York NY USA"},{"name":"Department of Urology Cochin Hospital, Assistance Publique\u2010Hopitaux de Paris, Paris Descartes University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Kent","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan\u2010Kettering Cancer Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Department of Urology Keio University School of Medicine Shinjuku\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Urology Keio University School of Medicine Shinjuku\u2010ku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaomi","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Urology Kitasato University School of Medicine Minami\u2010ku Sagamihara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumasa","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Urology Kitasato University School of Medicine Minami\u2010ku Sagamihara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orietta","family":"Dalpiaz","sequence":"additional","affiliation":[{"name":"Department of Urology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Zigeuner","sequence":"additional","affiliation":[{"name":"Department of Urology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atiqullah","family":"Aziz","sequence":"additional","affiliation":[{"name":"Department of Urology Caritas St. Josef Medical Centre University of Regensburg Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Martin","family":"Fritsche","sequence":"additional","affiliation":[{"name":"Department of Urology Caritas St. Josef Medical Centre University of Regensburg Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Deliere","sequence":"additional","affiliation":[{"name":"Division of Urology Penn State Milton S. Hershey Medical Center Hershey PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay D.","family":"Raman","sequence":"additional","affiliation":[{"name":"Division of Urology Penn State Milton S. Hershey Medical Center Hershey PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Bensalah","sequence":"additional","affiliation":[{"name":"Department of Urology Centre Hospitalier Universitaire de Rennes Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bikheet","family":"Al\u2010Matar","sequence":"additional","affiliation":[{"name":"Department of Urology University Medical Hospital of Tuebingen Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Gakis","sequence":"additional","affiliation":[{"name":"Department of Urology University Medical Hospital of Tuebingen Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Novara","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Gastroenterologic Sciences Urology Clinic University of Padua Padua 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