{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:29:26Z","timestamp":1791851366756,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T00:00:00Z","timestamp":1385942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2014,6]]},"abstract":"\n Objective<\/jats:title>\n \n \n \n \n To evaluate predictors of more aggressive disease and the role of multiparametric 3.0\u2010\n T<\/jats:styled-content>\n magnetic resonance imaging (\n MRI<\/jats:styled-content>\n ) in selecting patients with prostate cancer for active surveillance (\n AS<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n \n \n \n We retrospectively assessed 298 patients with prostate cancer who met the Prostate Cancer Research International: Active Surveillance (\n PRIAS<\/jats:styled-content>\n ) criteria, defined as\n T<\/jats:styled-content>\n 1c\/\n T<\/jats:styled-content>\n 2,\n PSA<\/jats:styled-content>\n level of \u226410\u2009ng\/mL,\n PSA<\/jats:styled-content>\n density (\n PSAD<\/jats:styled-content>\n ) of <0.2\u2009ng\/mL\n 2<\/jats:sup>\n ,\n G<\/jats:styled-content>\n leason score <7, and one or two positive biopsy cores.\n <\/jats:p>\n <\/jats:list-item>\n \n \n All patients underwent preoperative\n MRI<\/jats:styled-content>\n , including\n T<\/jats:styled-content>\n 2\u2010weighted, diffusion\u2010weighted, and dynamic contrast\u2010enhanced imaging, as well as radical prostatectomy (\n RP<\/jats:styled-content>\n ) between\n J<\/jats:styled-content>\n une 2005 and\n D<\/jats:styled-content>\n ecember 2011.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Imaging results were correlated with pathological findings to evaluate the ability of\n MRI<\/jats:styled-content>\n to select patients for\n AS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n \n \n In 35 (11.7%) patients, no discrete cancer was visible on\n MRI<\/jats:styled-content>\n , while in the remaining 263 (88.3%) patients, a discrete cancer was visible.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Pathological examination of\n RP<\/jats:styled-content>\n specimens resulted in upstaging (>\n T<\/jats:styled-content>\n 2) in 21 (7%) patients, upgrading (\n G<\/jats:styled-content>\n leason score >6) in 136 (45.6%), and a diagnosis of unfavourable disease in 142 (47.7%) patients.\n <\/jats:p>\n <\/jats:list-item>\n \n \n The 263 patients (88.3%) with visible cancer on imaging were more likely to have their cancer status upgraded (49.8% vs 14.3%) and be diagnosed with unfavourable disease (52.1% vs 14.3%) than the 35 patients (11.7%) with no cancer visible upon imaging, and these differences were statistically significant (\n P<\/jats:italic>\n < 0.001 for all).\n <\/jats:p>\n <\/jats:list-item>\n \n \n A visible cancer lesion on\n MRI<\/jats:styled-content>\n ,\n PSAD<\/jats:styled-content>\n , and patient age were found to be predictors of unfavourable disease in multivariate analysis.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n \n \n \n MRI<\/jats:styled-content>\n can predict adverse pathological features and be used to assess the eligibility of patients with prostate cancer for\n AS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12423","type":"journal-article","created":{"date-parts":[[2013,8,23]],"date-time":"2013-08-23T01:19:15Z","timestamp":1377220755000},"page":"864-870","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Role of multiparametric 3.0\u2010\n T<\/scp>\n esla magnetic resonance imaging in patients with prostate cancer eligible for active surveillance"],"prefix":"10.1111","volume":"113","author":[{"given":"Bong H.","family":"Park","sequence":"first","affiliation":[{"name":"Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwang G.","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seol H.","family":"Choo","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byong C.","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong I.","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong S.","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Y.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun M.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 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