{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T17:09:12Z","timestamp":1770916152396,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T00:00:00Z","timestamp":1385942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2014,7]]},"abstract":"\n Objective<\/jats:title>\n \n \n \n \n To evaluate the frequency of bladder outlet obstruction (\n BOO<\/jats:styled-content>\n ) and detrusor overactivity (\n DO<\/jats:styled-content>\n ) in patients with castration\u2010resistant prostate cancer (\n CRPC<\/jats:styled-content>\n ) and lower urinary tract symptoms (\n LUTS<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n \n \n Our prospective urodynamics database was queried.<\/jats:p>\n <\/jats:list-item>\n \n \n Inclusion criteria were\n CRPC<\/jats:styled-content>\n and an\n I<\/jats:styled-content>\n nternational\n P<\/jats:styled-content>\n rostate\n S<\/jats:styled-content>\n ymptom\n S<\/jats:styled-content>\n core (\n IPSS<\/jats:styled-content>\n ) \u2265 20.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Exclusion criteria were previous local therapy to the prostate gland, known urethral stricture disease, and a neurological component of\n LUTS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:list-item>\n \n Twenty\u2010one patients were identified.<\/jats:p>\n <\/jats:list-item>\n \n \n Urodynamic findings were analysed and compared with those of a matched cohort of 42 patients with benign prostatic enlargement (\n BPE<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n \n \n The median age of patients in the\n CRPC<\/jats:styled-content>\n group was 74 years, and the median prostate\u2010specific antigen (\n PSA<\/jats:styled-content>\n ) level at the time of the urodynamic study was 90\u2009ng\/mL.\n <\/jats:p>\n <\/jats:list-item>\n \n \n According to the\n BOO<\/jats:styled-content>\n index, three patients (14%) were obstructed, three were equivocally obstructed (14%) and 15 were unobstructed.\n <\/jats:p>\n <\/jats:list-item>\n \n \n DO<\/jats:styled-content>\n was seen in 12 patients (57%).\n <\/jats:p>\n <\/jats:list-item>\n \n \n Compared with the\n BPE<\/jats:styled-content>\n group, patients with\n CRPC<\/jats:styled-content>\n had lower cystometric bladder capacities (\n P<\/jats:italic>\n = 0.003), were less likely to have\n BOO<\/jats:styled-content>\n (14 vs 43%,\n P<\/jats:italic>\n = 0.009) and more likely to have\n DO<\/jats:styled-content>\n (57 vs 29%,\n P<\/jats:italic>\n = 0.028).\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n \n \n \n This study generates the hypothesis that only a minority of\n CRPC<\/jats:styled-content>\n patients with\n LUTS<\/jats:styled-content>\n have\n BOO<\/jats:styled-content>\n , and that more than half of patients have\n DO<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:list-item>\n \n LUTS in CRPC may therefore be seldom attributable to BOO, but are, at least in part, related to DO and reduced cystometric capacity.<\/jats:p>\n <\/jats:list-item>\n \n A urodynamic investigation may be necessary before palliative transurethral resection of the prostate to select appropriate candidates.<\/jats:p>\n <\/jats:list-item>\n \n Larger prospective studies are needed to confirm our findings.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12438","type":"journal-article","created":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T08:18:50Z","timestamp":1378369130000},"page":"62-66","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Bladder outlet obstruction (\n BOO<\/scp>\n ) in men with castration\u2010resistant prostate cancer"],"prefix":"10.1111","volume":"114","author":[{"given":"Maximilian","family":"Rom","sequence":"first","affiliation":[{"name":"Department of Urology Vienna General Hospital Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Waldert","sequence":"additional","affiliation":[{"name":"Department of Urology Vienna General Hospital Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Schatzl","sequence":"additional","affiliation":[{"name":"Department of 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