{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:07:27Z","timestamp":1790064447502,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T00:00:00Z","timestamp":1385942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2014,5]]},"abstract":"\n Objective<\/jats:title>\n \n \n \n \n To conduct a prospective comparison of quality\u2010of\u2010life (\n QoL<\/jats:styled-content>\n ) outcomes in patients who underwent ileal conduit (\n IC<\/jats:styled-content>\n ) urinary diversion with those who underwent orthotopic neobladder (\n ONB<\/jats:styled-content>\n ) reconstruction after radical cystectomy for invasive bladder cancers.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n \n \n \n Between\n J<\/jats:styled-content>\n anuary 2007 and\n D<\/jats:styled-content>\n ecember 2012, 227 patients underwent radical cystectomy and either\n IC<\/jats:styled-content>\n urinary diversion or\n ONB<\/jats:styled-content>\n (sigmoid or ileal) reconstruction.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Contraindications for\n ON<\/jats:styled-content>\n were impaired renal function (serum creatinine >2\u2009mg\/dL), chronic inflammatory bowel disease, previous bowel resection and tumour involvement at the bladder neck\/prostatic urethra. Patients who did not have these contraindications chose to undergo either\n IC<\/jats:styled-content>\n or\n ONB<\/jats:styled-content>\n reconstruction, after impartial counselling.\n <\/jats:p>\n <\/jats:list-item>\n \n Baseline characteristics, including demographic profile, body mass index, comorbidities, histopathology of the cystoprostatectomy (with lymph nodes) specimen, pathological tumour stage, postoperative complications, adjuvant therapy and relapse, were recorded and compared.<\/jats:p>\n <\/jats:list-item>\n \n \n The\n E<\/jats:styled-content>\n uropean\n O<\/jats:styled-content>\n rganization for\n R<\/jats:styled-content>\n esearch and\n T<\/jats:styled-content>\n reatment of\n C<\/jats:styled-content>\n ancer\n QoL<\/jats:styled-content>\n questionnaire\n C<\/jats:styled-content>\n 30 version 3 was used to analyse\n QoL<\/jats:styled-content>\n before surgery and 6, 12 and 18 months after surgery.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n \n \n Of the 227 patients, 28 patients in the\n IC<\/jats:styled-content>\n group and 35 in the\n ONB<\/jats:styled-content>\n group were excluded. The final analysis included 80 patients in the\n IC<\/jats:styled-content>\n and 84 in the\n ONB<\/jats:styled-content>\n group.\n <\/jats:p>\n <\/jats:list-item>\n \n \n None of the baseline characteristics were significantly different between the groups, except for age, but none of the baseline\n QoL<\/jats:styled-content>\n variables were found to be correlated with age.\n <\/jats:p>\n <\/jats:list-item>\n \n \n In the preoperative phase, there were no significant differences in any of the\n QoL<\/jats:styled-content>\n domains between the\n IC<\/jats:styled-content>\n or the\n ONB<\/jats:styled-content>\n groups. At 6, 12 and 18 months in the postoperative period, physical functioning (\n P<\/jats:italic>\n < 0.001,\n P<\/jats:italic>\n < 0.001 and\n P<\/jats:italic>\n = 0.001, respectively), role functioning (\n P<\/jats:italic>\n = 0.01,\n P<\/jats:italic>\n = 0.01 and\n P<\/jats:italic>\n = 0.003, respectively), social functioning (\n P<\/jats:italic>\n = 0.01,\n P<\/jats:italic>\n = 0.01 and\n P<\/jats:italic>\n = 0.01, respectively) and global health status\/\n QoL<\/jats:styled-content>\n (\n P<\/jats:italic>\n < 0.001,\n P<\/jats:italic>\n < 0.001 and\n P<\/jats:italic>\n = 0.002, respectively) were better in patients in the\n ONB<\/jats:styled-content>\n group than in those in the\n IC<\/jats:styled-content>\n group and the differences were significant.\n <\/jats:p>\n <\/jats:list-item>\n \n \n The financial burden related to bladder cancer treatment was significantly lower in the\n ONB<\/jats:styled-content>\n group than in the\n IC<\/jats:styled-content>\n group at 6, 12 and 18 months of follow\u2010up (\n P<\/jats:italic>\n = 0.05,\n P<\/jats:italic>\n = 0.05 and\n P<\/jats:italic>\n = 0.005, respectively)\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n \n \n \n ONB<\/jats:styled-content>\n is better than\n IC<\/jats:styled-content>\n in terms of physical functioning, role functioning, social functioning, global health status\/\n QoL<\/jats:styled-content>\n and financial expenditure.\n <\/jats:p>\n <\/jats:list-item>\n \n \n ONB<\/jats:styled-content>\n reconstruction provides better\n QoL<\/jats:styled-content>\n outcomes than does\n IC<\/jats:styled-content>\n urinary diversion.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n 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