{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:25:44Z","timestamp":1781677544505,"version":"3.54.5"},"reference-count":6,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T00:00:00Z","timestamp":1389744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2014,9]]},"abstract":"\n Objective<\/jats:title>\n \n \n \n To assess the role of centralized pathological review in penile cancer management.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n \n \n \n Newly diagnosed squamous cell carcinomas (SCC) of the penis, including squamous cell carcinoma in situ (\n CIS<\/jats:styled-content>\n ), from biopsy specimens were referred from 15 centres to the regional supra\u2010network multidisciplinary team (\n S<\/jats:styled-content>\n n\u2010\n MDT<\/jats:styled-content>\n ) between 1\n J<\/jats:styled-content>\n anuary 2008 and 30\n M<\/jats:styled-content>\n arch 2011.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Biopsy histology reports and slides from the respective referring hospitals were reviewed by the\n S<\/jats:styled-content>\n n\u2010\n MDT<\/jats:styled-content>\n pathologists.\n <\/jats:p>\n <\/jats:list-item>\n \n \n The biopsy specimens\u2019 histological type, grade and stage reported by the\n S<\/jats:styled-content>\n n\u2010\n MDT<\/jats:styled-content>\n pathologist were compared with those given in the referring hospital pathology report, as well as with definitive surgery histology.\n <\/jats:p>\n <\/jats:list-item>\n \n Any changes in histological diagnosis were sub\u2010divided into critical changes (i.e. those that could alter management) and non\u2010critical changes (i.e. those that would not affect management).<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n \n \n A total of 155 cases of squamous cell carcinoma or\n CIS<\/jats:styled-content>\n of the penis were referred from 15 different centres in\n N<\/jats:styled-content>\n orth\u2010\n W<\/jats:styled-content>\n est\n E<\/jats:styled-content>\n ngland.\n <\/jats:p>\n <\/jats:list-item>\n \n \n After review by the\n S<\/jats:styled-content>\n n\u2010\n MDT<\/jats:styled-content>\n , the histological diagnosis was changed in 31% of cases and this difference was statistically significant. A total of 60.4% of the changes were deemed to be critical changes that resulted in a significant change in management.\n <\/jats:p>\n <\/jats:list-item>\n \n \n When comparing the biopsy histology reported by the\n S<\/jats:styled-content>\n n\u2010\n MDT<\/jats:styled-content>\n with the final histology from the definitive surgical specimens, a good correlation was generally found.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n \n \n \n In the present study a significant proportion of penile cancer histology reports were revised after review by the\n S<\/jats:styled-content>\n n\u2010\n MDT<\/jats:styled-content>\n . Many of these changes altered patient management.\n <\/jats:p>\n <\/jats:list-item>\n \n The present study shows that accurate pathological diagnosis plays a crucial role in determining the correct treatment and maximizing the potential for good clinical outcomes in penile cancer.<\/jats:p>\n <\/jats:list-item>\n \n In the case of histopathology, centralization has increased exposure to penile cancer and thereby increased diagnostic accuracy, and should therefore be considered the \u2018gold standard\u2019.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12449","type":"journal-article","created":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T08:19:05Z","timestamp":1378369145000},"page":"340-343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Should centralized histopathological review in penile cancer be the global standard?"],"prefix":"10.1111","volume":"114","author":[{"given":"Vincent","family":"Tang","sequence":"first","affiliation":[{"name":"The Christie NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Clarke","sequence":"additional","affiliation":[{"name":"The Christie NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zara","family":"Gall","sequence":"additional","affiliation":[{"name":"Royal Bolton NHS Foundation Trust Bolton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H.","family":"Shanks","sequence":"additional","affiliation":[{"name":"The Christie NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Nonaka","sequence":"additional","affiliation":[{"name":"The Christie NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel J.","family":"Parr","sequence":"additional","affiliation":[{"name":"The Christie NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Anthony","family":"Elliott","sequence":"additional","affiliation":[{"name":"The Christie NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel W.","family":"Clarke","sequence":"additional","affiliation":[{"name":"The Christie NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Ramani","sequence":"additional","affiliation":[{"name":"The Christie NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice W.","family":"Lau","sequence":"additional","affiliation":[{"name":"The Christie NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay K.","family":"Sangar","sequence":"additional","affiliation":[{"name":"The Christie NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,15]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Rare Urological Cancer","author":"National Cancer Intelligence Network","year":"2012"},{"key":"e_1_2_6_3_1","volume-title":"Improving Outcomes in Urological Cancers","author":"National Institute for Clinical Excellence","year":"2002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66337-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.11.2327"},{"key":"e_1_2_6_6_1","volume-title":"Patient Volume and Quality: A Methodologically Based International Literature Review","author":"Tiesberg P","year":"2001"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1308\/003588410X12518836439047"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbju.12449","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.12449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T15:36:58Z","timestamp":1761752218000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.12449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,15]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/bju.12449"],"URL":"https:\/\/doi.org\/10.1111\/bju.12449","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,15]]},"assertion":[{"value":"2014-01-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}