{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T09:33:12Z","timestamp":1772703192050,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T00:00:00Z","timestamp":1389744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2014,8]]},"abstract":"\n Objective<\/jats:title>\n \n \n \n \n To evaluate the expression and prognostic value of epithelial cell adhesion\/activating molecule (\n EpCAM<\/jats:styled-content>\n ) in a large set of renal cell carcinomas (\n RCCs<\/jats:styled-content>\n ) using a tissue microarray (\n TMA<\/jats:styled-content>\n ) approach.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Material and Methods<\/jats:title>\n \n \n \n \n We studied the immunohistochemical expression and overexpression of\n EpCAM<\/jats:styled-content>\n on\n TMAs<\/jats:styled-content>\n containing formalin\u2010fixed, paraffin\u2010embedded samples of 948 patients with documented renal tumours.\n <\/jats:p>\n <\/jats:list-item>\n \n \n EpCAM<\/jats:styled-content>\n expression was defined as the presence of a specific membranous staining in >5% of the tumour cells.\n <\/jats:p>\n <\/jats:list-item>\n \n \n EpCAM<\/jats:styled-content>\n overexpression was specified by calculating a total staining score (score range 0\u201312) as the product of a proportion score and an intensity score, and defined as a score >4.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n \n \n Of 948 cases, 927 (97.8%) were evaluable morphologically (haematoxylin and eosin stain).\n EpCAM<\/jats:styled-content>\n expression was found in 233\/642 (36.3%), 126\/155 (81.3%), 54\/68 (78.3%), 17\/45 (37.8%), 13\/30 (43.3%) of clear\u2010cell\n RCC<\/jats:styled-content>\n , papillary\n RCC<\/jats:styled-content>\n (\n pRCC<\/jats:styled-content>\n ), chromophobe\n RCC<\/jats:styled-content>\n (\n cpRCC<\/jats:styled-content>\n ), oncocytomas and other unclassified tumour types, respectively.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Log\u2010rank tests showed a significantly longer overall survival (\n OS<\/jats:styled-content>\n [\n P<\/jats:italic>\n = 0.047]) and a trend of\n EpCAM<\/jats:styled-content>\n expression to be associated with a longer progression\u2010free survival (\n PFS<\/jats:styled-content>\n ) in all\n RCC<\/jats:styled-content>\n entities (\n P<\/jats:italic>\n = 0.065).\n <\/jats:p>\n <\/jats:list-item>\n \n \n EpCAM<\/jats:styled-content>\n overexpression was significantly correlated with a better\n PFS<\/jats:styled-content>\n in all\n RCC<\/jats:styled-content>\n subtypes,\n cpRCC<\/jats:styled-content>\n and\n pRCC<\/jats:styled-content>\n (\n P<\/jats:italic>\n = 0.011, 0.043 and 0.025, respectively).\n <\/jats:p>\n <\/jats:list-item>\n \n \n In multivariate analysis\n EpCAM<\/jats:styled-content>\n overexpression was an independent marker for longer\n PFS<\/jats:styled-content>\n in all\n RCC<\/jats:styled-content>\n entities as well as in high grade\n RCC<\/jats:styled-content>\n (\n P<\/jats:italic>\n = 0.009 and\n P<\/jats:italic>\n = 0.010, respectively).\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n \n \n \n The histological subtypes associated with a high rate of\n EpCAM<\/jats:styled-content>\n expression were\n cpRCC<\/jats:styled-content>\n and\n pRCC<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:list-item>\n \n \n This retrospective analysis demonstrated a trend towards longer\n OS<\/jats:styled-content>\n and\n PFS<\/jats:styled-content>\n for all major\n RCC<\/jats:styled-content>\n subtypes.\n <\/jats:p>\n <\/jats:list-item>\n \n \n EpCAM<\/jats:styled-content>\n expression had significant prognostic value in patients with\n cpRCC<\/jats:styled-content>\n and\n pRCC<\/jats:styled-content>\n . Furthermore,\n EpCAM<\/jats:styled-content>\n overexpression in high grade\n RCC<\/jats:styled-content>\n may be a helpful marker for prognostication.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12487","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T12:07:09Z","timestamp":1384171629000},"page":"296-302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Prognostic and diagnostic implications of epithelial cell adhesion\/activating molecule (\n EpCAM<\/scp>\n ) expression in renal tumours: a retrospective clinicopathological study of 948 cases using tissue microarrays"],"prefix":"10.1111","volume":"114","author":[{"given":"Annette","family":"Zimpfer","sequence":"first","affiliation":[{"name":"Institute of Pathology University of Rostock Rostock Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Maruschke","sequence":"additional","affiliation":[{"name":"Department of Urology University of Rostock Rostock Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Rehn","sequence":"additional","affiliation":[{"name":"Institute of Pathology University of Rostock Rostock Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guenter","family":"Kundt","sequence":"additional","affiliation":[{"name":"Institute for Biostatistics and Informatics in Medicine University of Rostock Rostock Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke","family":"Litzenberger","sequence":"additional","affiliation":[{"name":"Institute of Pathology University of Rostock Rostock Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friederike","family":"Dammert","sequence":"additional","affiliation":[{"name":"Institute of Pathology University of Rostock Rostock Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Zettl","sequence":"additional","affiliation":[{"name":"Clinical Cancer Registry University of Rostock Rostock Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Stephan","sequence":"additional","affiliation":[{"name":"Department of Urology Charit\u00e9 Berlin Germany"},{"name":"Berlin Institute for Urologic Research Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver W.","family":"Hakenberg","sequence":"additional","affiliation":[{"name":"Department of Urology University of Rostock Rostock Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Erbersdobler","sequence":"additional","affiliation":[{"name":"Institute of Pathology University of Rostock Rostock Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,15]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"10","volume-title":"World Health Organization Classification of Tumours. 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