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Their occurrence was not increased by 18 months\u2019\n AS<\/jats:styled-content>\n , nor reduced by\n ZdA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:list-item>\n \n \n Incident non\u2010spinal fractures occurred in 72 subjects and were significantly related to\n AS<\/jats:styled-content>\n duration but not to\n ZdA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:list-item>\n \n Osteopenia and osteoporosis prevalence rates at baseline were 23.4 and 1.4%, respectively, at the hip.<\/jats:p>\n <\/jats:list-item>\n \n \n Treatment for 6 and 18 months with\n AS<\/jats:styled-content>\n caused significant reductions in hip\n BMD<\/jats:styled-content>\n at 2 and 4 years (\n P<\/jats:italic>\n < 0.01) and\n ZdA<\/jats:styled-content>\n prevented these losses at both time points.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n \n \n \n In an\n AS<\/jats:styled-content>\n \u2010na\u00efve population, 18 months of\n ZdA<\/jats:styled-content>\n treatment prevented the sustained\n BMD<\/jats:styled-content>\n losses caused by 18 months of\n AS<\/jats:styled-content>\n treatment; however, the study power was insufficient to show that\n AS<\/jats:styled-content>\n duration or\n ZdA<\/jats:styled-content>\n influenced vertebral fracture rates.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12497","type":"journal-article","created":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T12:08:33Z","timestamp":1381838913000},"page":"344-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Impact of androgen suppression and zoledronic acid on bone mineral density and fractures in the Trans\u2010Tasman Radiation Oncology Group (\n TROG<\/scp>\n ) 03.04 Randomised Androgen Deprivation and Radiotherapy (\n RADAR<\/scp>\n ) randomized controlled trial for locally advanced prostate cancer"],"prefix":"10.1111","volume":"114","author":[{"given":"James W.","family":"Denham","sequence":"first","affiliation":[{"name":"School of Medicine and Public Health, University of Newcastle, Radiation Oncology Department, Calvary Mater Newcastle NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Nowitz","sequence":"additional","affiliation":[{"name":"Pacific Radiology Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Joseph","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Western Australia, School of Human Movement, Edith Cowan University, Sir Charles Gairdner Hospital Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Duchesne","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre Melbourne VIC 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