{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:24:35Z","timestamp":1765545875421,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T00:00:00Z","timestamp":1392854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2014,10]]},"abstract":"\n Objective<\/jats:title>\n \n To explore the effect of intravesical instillation of green tea extract (\n GTE<\/jats:styled-content>\n ) on a rat model of bacterial cystitis.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n In vitro<\/jats:italic>\n bactericidal properties of\n GTE<\/jats:styled-content>\n were analysed by adding\n GTE<\/jats:styled-content>\n to a suspension of uropathogenic\n \n E<\/jats:styled-content>\n .\u2009coli\n <\/jats:italic>\n (\n UPEC<\/jats:styled-content>\n ), streaking on\n M<\/jats:styled-content>\n ac\n C<\/jats:styled-content>\n onkey agar, and incubating overnight.\n <\/jats:p>\n \n In vivo<\/jats:italic>\n effects of intravesical instillation of\n GTE<\/jats:styled-content>\n on bacterial cystitis was analysed using a rat model of bacterial cystitis. In all, 42 female\n S<\/jats:styled-content>\n abra rats weighing 200\u2013260\u2009g were divided into five groups.\n <\/jats:p>\n Parameters measured were bladder weight (percentage of the total rat weight), dipstick urine analysis and histopathological changes in the bladder. Histological changes evaluated were degree of oedema, mixed inflammatory infiltration, urothelial epithelial invasion by neutrophils and reactive atypia.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n No\n in vitro<\/jats:italic>\n bactericidal activity was detected for\n GTE<\/jats:styled-content>\n .\n <\/jats:p>\n \n Intravesical instillation of\n GTE<\/jats:styled-content>\n did not cause damage to the rat bladders.\n <\/jats:p>\n \n Intravesical instillation of\n GTE<\/jats:styled-content>\n attenuated the inflammatory response to\n UPEC<\/jats:styled-content>\n \u2010\n SR<\/jats:styled-content>\n 71\u2010induced bacterial cystitis in this rat model.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Intravesical instillation of\n GTE<\/jats:styled-content>\n attenuated the inflammatory response to\n UPEC<\/jats:styled-content>\n \u2010\n SR<\/jats:styled-content>\n 71\u2010induced bacterial cystitis and is a novel approach to the treatment of bacterial cystitis.\n <\/jats:p>\n \n High concentrations of intravesical\n GTE<\/jats:styled-content>\n did not cause histologically evident damage to the rat bladder.\n <\/jats:p>\n The results of this study are preliminary and further studies will be needed to explore the feasibility of using this approach in humans.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12544","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T07:05:25Z","timestamp":1383203125000},"page":"601-607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Intravesical administration of green tea extract attenuates the inflammatory response of bacterial cystitis \u2013 a rat model"],"prefix":"10.1111","volume":"114","author":[{"given":"Shilo","family":"Rosenberg","sequence":"first","affiliation":[{"name":"Department of Urology Hadassah Medical Center Hebrew University Jerusalem 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