{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:33:40Z","timestamp":1791232420002,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T00:00:00Z","timestamp":1397606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2014,10]]},"abstract":"\n Objective<\/jats:title>\n \n \n \n \n To report the oncological and functional outcomes of hemi salvage high\u2010intensity focused ultrasound (\n HSH<\/jats:styled-content>\n ) in patients with unilateral radiorecurrent prostate cancer.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n \n \n \n Between 2009 and 2012, 48 patients were prospectively enrolled in two\n E<\/jats:styled-content>\n uropean centres. Inclusion criteria were biochemical recurrence (\n BCR<\/jats:styled-content>\n ) after primary radiotherapy (\n RT<\/jats:styled-content>\n ), positive magnetic resonance imaging and \u22651 positive biopsy in only one lobe.\n <\/jats:p>\n <\/jats:list-item>\n \n \n BCR<\/jats:styled-content>\n was defined using\n P<\/jats:styled-content>\n hoenix criteria (a rise by \u22652\u2009ng\/mL above the nadir prostate specific antigen [\n PSA<\/jats:styled-content>\n ] level).\n <\/jats:p>\n <\/jats:list-item>\n \n \n The following schemes and criteria for functional outcomes were used:\n I<\/jats:styled-content>\n ngelman\u2010\n S<\/jats:styled-content>\n undberg score using\n I<\/jats:styled-content>\n nternational\n C<\/jats:styled-content>\n ontinence\n S<\/jats:styled-content>\n ociety (\n ICS<\/jats:styled-content>\n ) questionnaire (\n A<\/jats:styled-content>\n and\n B<\/jats:styled-content>\n ),\n I<\/jats:styled-content>\n nternational prostate symptom score (\n IPSS<\/jats:styled-content>\n ),\n I<\/jats:styled-content>\n nternational\n I<\/jats:styled-content>\n ndex of\n E<\/jats:styled-content>\n rectile\n F<\/jats:styled-content>\n unction\u20105 (\n IIEF<\/jats:styled-content>\n \u20105) points, the\n E<\/jats:styled-content>\n uropean\n O<\/jats:styled-content>\n rganisation for the\n R<\/jats:styled-content>\n esearch and\n T<\/jats:styled-content>\n reatment of\n C<\/jats:styled-content>\n ancer (\n EORTC<\/jats:styled-content>\n ) quality of life questionnaires (\n QLQ C<\/jats:styled-content>\n \u201030).\n <\/jats:p>\n <\/jats:list-item>\n \n \n HSH<\/jats:styled-content>\n was performed under spinal or general anaesthesia using the\n A<\/jats:styled-content>\n blatherm\n \u00ae<\/jats:sup>\n I<\/jats:styled-content>\n ntegrated\n I<\/jats:styled-content>\n maging device. Patients with obstructive voiding symptoms at the time of treatment underwent an endoscopic bladder neck resection or incision during the same anaesthesia to prevent the risk of postoperative obstruction.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n \n \n \n After\n HSH<\/jats:styled-content>\n the mean (\n sd<\/jats:sc>\n )\n PSA<\/jats:styled-content>\n nadir was 0.69 (0.83) ng\/mL at a median (interquartile range) follow\u2010up of 16.3 (10.5\u201324.5) months.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Disease progression occurred in 16\/48 (33%). Of these, four had local recurrence in the untreated lobe and four bilaterally, six developed metastases, and two had rising\n PSA<\/jats:styled-content>\n levels without local recurrence or radiological confirmed metastasis. Progression\u2010free survival rates at 12, 18, and 24 months were 83%, 64%, and 52%.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Severe incontinence occurred in four of the 48 patients (8%), eight (17%) required one pad a day, and 36\/48 (75%) were pad\u2010free. The\n ICS<\/jats:styled-content>\n questionnaire showed a mean (\n sd<\/jats:sc>\n ) deterioration from 0.7 (2.0) to 2.3 (4.5) for scores\n A<\/jats:styled-content>\n and 0.6 (1.4) to 1.6 (3.0) for\n B<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:list-item>\n \n \n The mean (\n sd<\/jats:sc>\n )\n IPSS<\/jats:styled-content>\n and erectile function (\n IIEF<\/jats:styled-content>\n \u20105) scores decreased from a mean (\n sd<\/jats:sc>\n ) of 7.01 (5.6) to 8.6 (5.1) and from 11.2 (8.6) to 7.0 (5.8), respectively.\n <\/jats:p>\n <\/jats:list-item>\n \n \n The mean (\n sd<\/jats:sc>\n )\n EORTC QLC<\/jats:styled-content>\n \u201030 scores before and after\n HSH<\/jats:styled-content>\n were 35.7 (8.6) vs 36.8 (8.6).\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n \n \n \n HSH<\/jats:styled-content>\n is a feasible therapeutic option in patients with unilateral radiorecurrent prostate cancer, which offers limited urinary and rectal morbidity, and preserves health\u2010related quality of life.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12545","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T07:05:29Z","timestamp":1383203129000},"page":"532-540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Hemi salvage high\u2010intensity focused ultrasound (\n HIFU<\/scp>\n ) in unilateral radiorecurrent prostate cancer: a prospective two\u2010centre study"],"prefix":"10.1111","volume":"114","author":[{"given":"Eduard","family":"Baco","sequence":"first","affiliation":[{"name":"Division of Surgery and Cancer Medicine Department of Urology Oslo University Hospital Aker Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Gelet","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon Department 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