{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:35:51Z","timestamp":1793763351641,"version":"4.6.1"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,7,27]],"date-time":"2014-07-27T00:00:00Z","timestamp":1406419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Abbvie Pty Ltd","award":["-"],"award-info":[{"award-number":["-"]}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To determine if supervised exercise minimises treatment toxicity in patients with prostate cancer initiating androgen\u2010deprivation therapy (\n                      <jats:styled-content style=\"fixed-case\">ADT<\/jats:styled-content>\n                      ). This is the first study to date that has investigated the potential role of exercise in preventing\n                      <jats:styled-content style=\"fixed-case\">ADT<\/jats:styled-content>\n                      toxicity rather than recovering from established toxicities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010three men scheduled to receive\n                      <jats:styled-content style=\"fixed-case\">ADT<\/jats:styled-content>\n                      were randomly assigned to a 3\u2010month supervised exercise programme involving aerobic and resistance exercise sessions commenced within 10 days of their first\n                      <jats:styled-content style=\"fixed-case\">ADT<\/jats:styled-content>\n                      injection (32 men) or usual care (31 men). The primary outcome was body composition (lean and fat mass). Other study outcomes included bone mineral density, physical function, blood biomarkers of chronic disease risk and bone turnover, general and prostate cancer\u2010specific quality of life, fatigue and psychological distress. Outcomes were compared between groups using analysis of covariance adjusted for baseline values.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to usual care, a 3\u2010month exercise programme preserved appendicular lean mass (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.019) and prevented gains in whole body fat mass, trunk fat mass and percentage fat with group differences of \u22121.4\u2009kg (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001), \u22120.9\u2009kg (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.008) and \u22121.3% (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), respectively. Significant between\u2010group differences were also seen favouring the exercise group for cardiovascular fitness (peak oxygen consumption 1.1\u2009mL\/kg\/min,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.004), muscular strength (4.0\u201325.9\u2009kg,\n                      <jats:italic>P<\/jats:italic>\n                      \u2264 0.026), lower body function (\u20131.1\u2009s,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), total cholesterol: high\u2010density lipoprotein\u2010cholesterol ratio (\u20130.52,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.028), sexual function (15.2,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.028), fatigue (3.1,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.042), psychological distress (\u20132.2,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.045), social functioning (3.8,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.015) and mental health (3.6\u20133.8,\n                      <jats:italic>P<\/jats:italic>\n                      \u2264 0.022). There were no significant group differences for any other outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Commencing a supervised exercise programme involving aerobic and resistance exercise when initiating\n                      <jats:styled-content style=\"fixed-case\">ADT<\/jats:styled-content>\n                      significantly reduced treatment toxicity, while improving social functioning and mental health. Concurrent prescription of supervised exercise when initiating\n                      <jats:styled-content style=\"fixed-case\">ADT<\/jats:styled-content>\n                      is therefore advised to minimise morbidity associated with severe hypogonadism.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.12646","type":"journal-article","created":{"date-parts":[[2014,1,27]],"date-time":"2014-01-27T06:56:41Z","timestamp":1390805801000},"page":"256-266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":247,"title":["Can supervised exercise prevent treatment toxicity in patients with prostate cancer initiating androgen\u2010deprivation therapy: a randomised controlled trial"],"prefix":"10.1111","volume":"115","author":[{"given":"Prue","family":"Cormie","sequence":"first","affiliation":[{"name":"Edith Cowan University Health and Wellness Institute Edith Cowan University  Joondalup Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Galv\u00e3o","sequence":"additional","affiliation":[{"name":"Edith Cowan University Health and Wellness Institute Edith Cowan University  Joondalup Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Spry","sequence":"additional","affiliation":[{"name":"Edith Cowan University Health and Wellness Institute Edith Cowan University  Joondalup Australia"},{"name":"Genesis Cancer Care  Joondalup Australia"},{"name":"Department of Radiation Oncology Sir Charles Gairdner Hospital  Nedlands Australia"},{"name":"Faculty of Medicine University of Western Australia  Nedlands Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Joseph","sequence":"additional","affiliation":[{"name":"Edith Cowan University Health and Wellness Institute Edith Cowan University  Joondalup Australia"},{"name":"Department of Radiation Oncology Sir Charles Gairdner Hospital  Nedlands Australia"},{"name":"Faculty of Medicine University of Western Australia  Nedlands Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Chee","sequence":"additional","affiliation":[{"name":"Genesis Cancer Care  Joondalup Australia"},{"name":"Faculty of Medicine University of Western Australia  Nedlands Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis R.","family":"Taaffe","sequence":"additional","affiliation":[{"name":"Edith Cowan University Health and Wellness Institute Edith Cowan University  Joondalup Australia"},{"name":"School of Environmental and Life Sciences University of Newcastle  Ourimbah Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne K.","family":"Chambers","sequence":"additional","affiliation":[{"name":"Edith Cowan University Health and Wellness Institute Edith Cowan University  Joondalup Australia"},{"name":"Griffith Health Institute Griffith University  Southport Australia"},{"name":"Cancer Council Queensland  Brisbane Australia"},{"name":"Prostate Cancer Foundation of Australia  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert U.","family":"Newton","sequence":"additional","affiliation":[{"name":"Edith Cowan University Health and Wellness Institute Edith Cowan University  Joondalup Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11774.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.07539.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2012.33"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.8850"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2010.03942.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21642"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08458.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192695"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.05.9741"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041943"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.01.080"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.01.029"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2008.51"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.29.8091"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2011.02.005"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.2488"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2012.52"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.09.534"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.4963"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.09.041"},{"key":"e_1_2_8_22_1","unstructured":"HeidenreichA BollaM JoniauSet\u2009al.European Association of Urology guidelines on prostate cancer.2013. Available athttp:\/\/www.uroweb.org\/gls\/pdf\/09_Prostate_Cancer_LR.pdf. Accessed Januray 2014"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000233803.48691.8b"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls206"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1023"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-009-0694-3"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1123\/japa.21.4.455"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.05.055"},{"key":"e_1_2_8_29_1","volume-title":"Borg's Perceived Exertion and Pain Scales","author":"Borg G","year":"1998"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181e0c112"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0902"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.00530.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/53A.4.M287"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.07.030"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(96)00274-6"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.42.3.241"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079907X178757"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67663-5"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801891"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10555.x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1123\/jpah.8.1.18","article-title":"Fitness and adiposity as predictors of functional limitation in adults","volume":"8","author":"Maslow AL","year":"2011","journal-title":"J Phys Act Health"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.21.2507"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.12.025"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(92)90288-7"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2013.206"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1800.2005.00258.x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9566.2006.00499.x"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-013-1868-6"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.2004.03331.x"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2006.tb00124.x"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbju.12646","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.12646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:59:32Z","timestamp":1761749972000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.12646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,27]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/bju.12646"],"URL":"https:\/\/doi.org\/10.1111\/bju.12646","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,27]]},"assertion":[{"value":"2014-07-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}