{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:23:01Z","timestamp":1791249781657,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,16]],"date-time":"2014-08-16T00:00:00Z","timestamp":1408147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2015,2]]},"abstract":"\n Objective<\/jats:title>\n \n To compare the clinical reliability of the 1973 and 2004 World Health Organisation (\n WHO<\/jats:styled-content>\n ) classification systems in\n pT1<\/jats:styled-content>\n bladder cancer.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n We retrospectively evaluated 291 consecutive patients who had\n pT1<\/jats:styled-content>\n high grade bladder cancer between 2004 and 2011. All tumours were simultaneously evaluated by a single uro\u2010pathologist as high grade and\n G2<\/jats:styled-content>\n or\n G3<\/jats:styled-content>\n . All patients underwent a second transurethral resection (\n TUR<\/jats:styled-content>\n ) and those confirmed with non\u2010muscle\u2010invasive bladder cancer at second\n TUR<\/jats:styled-content>\n received bacille\n C<\/jats:styled-content>\n almette\u2010\n G<\/jats:styled-content>\n u\u00e9rin. Follow\u2010up included urine cytology and cystoscopy 3 months after second\n TUR<\/jats:styled-content>\n and then every 6 months for 5 years. Univariate and multivariate analysis to determine recurrence\u2010free survival (\n RFS<\/jats:styled-content>\n ) and progression\u2010free survival (\n PFS<\/jats:styled-content>\n ) rates were performed using the\n K<\/jats:styled-content>\n aplan\u2013\n M<\/jats:styled-content>\n eier method with the log\u2010rank test.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n G2<\/jats:styled-content>\n tumours were found in 124 (46.6%) and\n G3<\/jats:styled-content>\n in 142 (53.4%) patients. The mean (median; range) follow\u2010up period was 31.1 (19; 1\u201393) months. The 5\u2010year\n RFS<\/jats:styled-content>\n rate was 39.1% for the overall high grade population, and 49.1 and 31.8% for\n G2<\/jats:styled-content>\n and\n G3<\/jats:styled-content>\n subgroups, respectively. The 5\u2010year\n PFS<\/jats:styled-content>\n was 82% for the overall high grade population and 89 and 73% for\n G2<\/jats:styled-content>\n and\n G3<\/jats:styled-content>\n subgroups, respectively.\n RFS<\/jats:styled-content>\n (\n P<\/jats:italic>\n < 0.002) and\n PFS<\/jats:styled-content>\n (\n P<\/jats:italic>\n < 0.001) rates were significantly different between the\n G2<\/jats:styled-content>\n and\n G3<\/jats:styled-content>\n subgroups. In multivariate analysis, only the grade assessed according to the 1973\n WHO<\/jats:styled-content>\n significantly correlated with both\n RFS<\/jats:styled-content>\n (\n P<\/jats:italic>\n = 0.003) and\n PFS<\/jats:styled-content>\n (\n P<\/jats:italic>\n < 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The results suggest that the 1973\n WHO<\/jats:styled-content>\n classification system has higher prognostic reliability for patients with\n T1<\/jats:styled-content>\n disease. If confirmed, these findings should be carefully taken into account when making treatment decisions for patients with\n T1<\/jats:styled-content>\n bladder cancer.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12666","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T06:46:11Z","timestamp":1392187571000},"page":"267-273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Oncological predictive value of the 2004 World Health Organisation grading classification in primary\n T1<\/scp>\n non\u2010muscle\u2010invasive bladder cancer. A step forward or back?"],"prefix":"10.1111","volume":"115","author":[{"given":"Federico","family":"Pellucchi","sequence":"first","affiliation":[{"name":"Department of Urology Scientific Institute San Raffaele \u2018Vita\u2010Salute University\u2019 and Urological Research Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Freschi","sequence":"additional","affiliation":[{"name":"Department of Pathology Scientific Institute San Raffaele \u2018Vita\u2010Salute University\u2019 and Urological Research Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Moschini","sequence":"additional","affiliation":[{"name":"Department of Urology IRCCS Arcispedale Santa Maria Nuova Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Rocchini","sequence":"additional","affiliation":[{"name":"Department of Urology IRCCS Arcispedale Santa Maria Nuova Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Maccagnano","sequence":"additional","affiliation":[{"name":"Department of Urology IRCCS Arcispedale Santa Maria Nuova Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suardi","family":"Nazareno","sequence":"additional","affiliation":[{"name":"Department of Urology IRCCS Arcispedale Santa Maria Nuova Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Bergamaschi","sequence":"additional","affiliation":[{"name":"Department of Urology Scientific Institute San Raffaele \u2018Vita\u2010Salute University\u2019 and Urological Research Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Montorsi","sequence":"additional","affiliation":[{"name":"Department of Urology IRCCS Arcispedale Santa Maria Nuova Reggio Emilia 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.12.031"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199812000-00001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90153-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.12.900"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(03)00073-8"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-003-0905-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000080828"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000100839"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP12MRVVHTCKEJ"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2010.079764"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.06.003"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.09.003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2013.0059"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.5858\/2009-0403-OA.1","article-title":"Low\u2010gradepapillary 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