{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:43:23Z","timestamp":1791229403820,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T00:00:00Z","timestamp":1408406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH\/NIA","award":["NIH 5R01AG028657-02"],"award-info":[{"award-number":["NIH 5R01AG028657-02"]}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2015,2]]},"abstract":"\n Objective<\/jats:title>\n To test the hypothesis that ageing is associated with increasing neurogenic enhancement of bladder filling compliance.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n Female\n B<\/jats:styled-content>\n 6 mice (aged 2, 12, 22 and 26 months) underwent cystometry while alive and immediately after death. Bladder compliance was calculated from pressure\u2010time data. Pressure data were transformed using\n F<\/jats:styled-content>\n ast\n F<\/jats:styled-content>\n ourier\n T<\/jats:styled-content>\n ransform to obtain power spectra of bladder pressure variations attributable to contractile activity during filling in both alive and dead mice.\n A<\/jats:styled-content>\n cut\u2010off frequency (\n CF<\/jats:styled-content>\n ) was determined for each mouse, above which any power content would be primarily neurogenic. Compliance and power spectra results were compared among age groups, and correlations sought.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A reversible loss of bladder compliance and non\u2010voiding contractile (\n NVC<\/jats:styled-content>\n ) activity followed abolition of voiding reflexes in female colony mice in all age groups. Bladder filling compliance increased with age in urethane\u2010anaesthetised and post\u2010mortem conditions, and more so in the former. Power below the\n CF<\/jats:styled-content>\n did not significantly vary with age. Neurogenic power increased with age, and significantly correlated with compliance.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n An increase in neurogenic power during filling accompanies increased centrally mediated compliance enhancement with age. A bladder control model in which brain processes related to micturition may compensate for age\u2010associated changes; thereby preserving voiding function is suggested. Urinary dysfunction could be viewed as the result of homeostatic failure rather than strictly end\u2010organ pathology.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12669","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T06:46:12Z","timestamp":1392187572000},"page":"322-329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Evidence of increased centrally enhanced bladder compliance with ageing in a mouse model"],"prefix":"10.1111","volume":"115","author":[{"given":"Phillip P.","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Surgery University of Connecticut Health Center Farmington CT USA"},{"name":"Center on Aging University of Connecticut Health Center Farmington CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"DeAngelis","sequence":"additional","affiliation":[{"name":"Center on Aging University of 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