{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:50:31Z","timestamp":1791571831987,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"6b","license":[{"start":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T00:00:00Z","timestamp":1413590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2014,12]]},"abstract":"\n Objective<\/jats:title>\n \n To describe the detection rate of anteriorly located prostate cancer (\n PCa<\/jats:styled-content>\n ) with the addition of magnetic resonance imaging (\n MRI<\/jats:styled-content>\n )\/ultrasonography (\n US<\/jats:styled-content>\n ) fusion\u2010guided biopsy (\n FGB<\/jats:styled-content>\n ) to the standard transrectal ultrasonography (\n TRUS<\/jats:styled-content>\n )\u2010guided biopsy.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n All patients, regardless of their biopsy history, who were referred for clinical suspicion of\n PCa<\/jats:styled-content>\n (i.e elevated prostate\u2010specific antigen (\n PSA<\/jats:styled-content>\n ) level and abnormal digital rectal examination) underwent\n 3T<\/jats:styled-content>\n multiparametric\u2010\n MRI<\/jats:styled-content>\n (\n mpMRI<\/jats:styled-content>\n ) screening; and those with suspicious lesions in the anterior region of the prostate were identified. Patients then received a\n FGB<\/jats:styled-content>\n of all suspicious lesions in addition to a systematic 12\u2010core extended sextant\n TRUS<\/jats:styled-content>\n \u2010guided biopsy. We conducted a lesion\u2010based analysis comparing cancer detection rates of anterior targets using\n FGB<\/jats:styled-content>\n vs systematic cores taken from the same anatomic sextant within the prostate. Lengths of cancer in the most involved core were also compared between the two biopsy techniques used. Patients with only anterior targets were analysed separately.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 499 patients undergoing\n FGB<\/jats:styled-content>\n , 162 had a total of 241 anterior lesions. The mean age,\n PSA<\/jats:styled-content>\n level and prostate volume in this group were 62 years, 12.7\u2009ng\/dL, and 57\u2009mL, respectively. In total,\n PCa<\/jats:styled-content>\n was diagnosed in 121 anterior lesions (50.2%) identified on\n mpMRI<\/jats:styled-content>\n . Sixty\u2010two (25.7%) of these anterior lesions were documented as positive for cancer on systematic 12\u2010core\n TRUS<\/jats:styled-content>\n \u2010guided biopsy cores, while 97 (40.2%) were positive on the targeted\n FGB<\/jats:styled-content>\n cores (\n P<\/jats:italic>\n = 0.001). In lesions that were positive on both\n FGB<\/jats:styled-content>\n and\n TRUS<\/jats:styled-content>\n biopsy, the most involved core was 112% longer on\n FGB<\/jats:styled-content>\n (3.7 vs 1.6\u2009mm,\n P<\/jats:italic>\n \u2264 0.01). Forty\u2010two patients had only anterior lesions on mpMRI; of these, 24 (57.1%) were found to have cancer on the\n FGB<\/jats:styled-content>\n +\n TRUS<\/jats:styled-content>\n biopsy platform. Six patients were positive on\n FGB<\/jats:styled-content>\n only and 13 were positive on both biopsy techniques; however, 7\/13 patients were upgraded to a higher Gleason score after\n FGB<\/jats:styled-content>\n . All five patients positive on\n TRUS<\/jats:styled-content>\n biopsy only were candidates for active surveillance.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The results showed that\n FGB<\/jats:styled-content>\n detects significantly more anteriorly located\n PCa<\/jats:styled-content>\n than does\n TRUS<\/jats:styled-content>\n \u2010guided biopsy alone and it may serve as an effective tool for the subset of patients with such tumours.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12670","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T06:46:12Z","timestamp":1392187572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Multiparametric magnetic resonance imaging (\n MRI<\/scp>\n ) and subsequent\n MRI<\/scp>\n \/ultrasonography fusion\u2010guided biopsy increase the detection of anteriorly located prostate cancers"],"prefix":"10.1111","volume":"114","author":[{"given":"Dmitry","family":"Volkin","sequence":"first","affiliation":[{"name":"Urologic Oncology Branch National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baris","family":"Turkbey","sequence":"additional","affiliation":[{"name":"Molecular Imaging Program National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony N.","family":"Hoang","sequence":"additional","affiliation":[{"name":"Urologic Oncology Branch National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soroush","family":"Rais\u2010Bahrami","sequence":"additional","affiliation":[{"name":"Urologic Oncology Branch National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Yerram","sequence":"additional","affiliation":[{"name":"Urologic Oncology Branch National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annerleim","family":"Walton\u2010Diaz","sequence":"additional","affiliation":[{"name":"Urologic Oncology Branch National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey W.","family":"Nix","sequence":"additional","affiliation":[{"name":"Urologic Oncology Branch National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford J.","family":"Wood","sequence":"additional","affiliation":[{"name":"Center for Interventional Oncology National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L.","family":"Choyke","sequence":"additional","affiliation":[{"name":"Molecular Imaging Program National Institutes of Health Bethesda MD 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