{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T06:57:57Z","timestamp":1793775477316,"version":"4.6.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T00:00:00Z","timestamp":1431475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To develop a novel postoperative prognostic tool, which attempts to integrate both pathological tumour stage and histopathological factors, for prediction of cancer\u2010specific mortality (\n                      <jats:styled-content style=\"fixed-case\">CSM<\/jats:styled-content>\n                      ) of squamous cell carcinoma of the penis (\n                      <jats:styled-content style=\"fixed-case\">SCCP<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Patients with\n                      <jats:styled-content style=\"fixed-case\">SCCP<\/jats:styled-content>\n                      treated with inguinal lymph node dissection (\n                      <jats:styled-content style=\"fixed-case\">ILND<\/jats:styled-content>\n                      ) or sentinel\n                      <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>\n                      biopsy at a single institution were used for nomogram development and internal validation (\n                      <jats:italic>n<\/jats:italic>\n                      = 434), while a second cohort was used for external validation (\n                      <jats:italic>n<\/jats:italic>\n                      = 338). Multivariable\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      ox proportional hazards were used to examine the prognostic ability of patient age, a modified tumour staging that distinguishes between spongiosum and cavernosum body ingrowth tumours, a modified\n                      <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>\n                      staging that integrates information on presence\/absence of\n                      <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>\n                      metastasis, extent of inguinal\n                      <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>\n                      metastases, pelvic\n                      <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>\n                      involvement, and extranodal involvement, and tumour grade. Model performance was quantified using measures of discrimination and calibration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 36% of patients had positive\n                      <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>\n                      metastases (\n                      <jats:italic>n<\/jats:italic>\n                      = 156). In univariable analyses, the modified tumour and\n                      <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>\n                      staging systems were statistically significantly associated with\n                      <jats:styled-content style=\"fixed-case\">CSM<\/jats:styled-content>\n                      , and remained in the final model with a discrimination of 89% within internal validation, and 95% within external validation. Calibration was nearly perfect.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The newly developed model integrates important prognostic factors, which existing models do not consider. Its performance was highly accurate using measures of discrimination and calibration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.12677","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T03:02:26Z","timestamp":1392865346000},"page":"734-743","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Development and external validation of a prognostic tool for prediction of cancer\u2010specific mortality after complete loco\u2010regional pathological staging for squamous cell carcinoma of the penis"],"prefix":"10.1111","volume":"116","author":[{"given":"Maxine","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Urology Cancer Prognostics and Health Outcomes Unit University of Montreal Health Center Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa S.","family":"Djajadiningrat","sequence":"additional","affiliation":[{"name":"Department of Urology Netherlands Cancer Institute\u2010Antoni van Leeuwenhoek Hospital Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussain M.","family":"Alnajjar","sequence":"additional","affiliation":[{"name":"Penile Cancer Centre St George's Healthcare NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3857-9276","authenticated-orcid":false,"given":"Quoc\u2010Dien","family":"Trinh","sequence":"additional","affiliation":[{"name":"Department of Urology Cancer Prognostics and Health Outcomes Unit University of Montreal Health Center Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels M.","family":"Graafland","sequence":"additional","affiliation":[{"name":"Department of Urology Netherlands Cancer Institute\u2010Antoni van Leeuwenhoek Hospital Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Watkin","sequence":"additional","affiliation":[{"name":"Penile Cancer Centre St George's Healthcare NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre I.","family":"Karakiewicz","sequence":"additional","affiliation":[{"name":"Department of Urology Cancer Prognostics and Health Outcomes Unit University of Montreal Health Center Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Horenblas","sequence":"additional","affiliation":[{"name":"Department of Urology Netherlands Cancer Institute\u2010Antoni van Leeuwenhoek Hospital Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.01.039"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.02.038"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21076"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-008-0274-z"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpuro0751"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20414"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(06)00313-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.09.111"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1888"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.05.011"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.06.016"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.02.037"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-192102000-00001"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)36126-8"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ssu.2980060411"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1993.tb16273.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3104"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.10.766"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4"},{"key":"e_1_2_7_21_1","unstructured":"HarrellF.Regression Modeling Strategies 2013. 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