{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:45:48Z","timestamp":1773027948381,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T00:00:00Z","timestamp":1421798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To identify risk factors and develop a model for predicting recurrence of upper urinary tract urothelial carcinoma (\n                      <jats:styled-content style=\"fixed-case\">UTUC<\/jats:styled-content>\n                      ) in the bladder in patients without a history of bladder cancer after radical nephroureterectomy (\n                      <jats:styled-content style=\"fixed-case\">RNU<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively reviewed 754 patients with\n                      <jats:styled-content style=\"fixed-case\">UTUC<\/jats:styled-content>\n                      without prior or concurrent bladder cancer or distant metastasis at 13 institutions in\n                      <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>\n                      apan. Univariate and multivariate\n                      <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>\n                      ine and\n                      <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>\n                      ray competing risks proportional hazards models were used to examine the cumulative incidence of bladder recurrence of\n                      <jats:styled-content style=\"fixed-case\">UTUC<\/jats:styled-content>\n                      . A risk stratification model and a nomogram were constructed. Two prediction models were compared using the concordance index (c\u2010index) focusing on predictive accuracy and decision\u2010curve analysis, which indicate whether a model is appropriate for decision\u2010making and determining subsequent patient prognosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cumulative incidence rates of bladder\n                      <jats:styled-content style=\"fixed-case\">UTUC<\/jats:styled-content>\n                      recurrence at 1 and 5 years were 15 and 29%, respectively; the median time to bladder\n                      <jats:styled-content style=\"fixed-case\">UTUC<\/jats:styled-content>\n                      recurrence was 10 months. Multivariate analysis showed that papillary tumour architecture, absence of lymphovascular invasion and higher pathological\n                      <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                      stage were both predictive factors for bladder cancer recurrence. The predictive accuracy of the risk stratification model and the nomogram for bladder cancer recurrence were not different (c\u2010index: 0.60 and 0.62). According to the decision\u2010curve analysis, the risk stratification was an acceptable model because the net benefit of the risk stratification was equivalent to that of the nomogram. The overall cumulative incidence rates of bladder cancer 5 years after\n                      <jats:styled-content style=\"fixed-case\">RNU<\/jats:styled-content>\n                      were 10, 26 and 44% in the low\u2010, intermediate\u2010 and high\u2010risk groups, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      We identified risk factors and developed a risk stratification model for\n                      <jats:styled-content style=\"fixed-case\">UTUC<\/jats:styled-content>\n                      recurrence in the bladder after\n                      <jats:styled-content style=\"fixed-case\">RNU<\/jats:styled-content>\n                      . This model could be used to provide both an individualised strategy to prevent recurrence and a risk\u2010stratified surveillance protocol.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.12707","type":"journal-article","created":{"date-parts":[[2014,2,25]],"date-time":"2014-02-25T04:53:13Z","timestamp":1393303993000},"page":"705-712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Risk stratification for bladder recurrence of upper urinary tract urothelial carcinoma after radical nephroureterectomy"],"prefix":"10.1111","volume":"115","author":[{"given":"Junichiro","family":"Ishioka","sequence":"first","affiliation":[{"name":"Department of Urology Tokyo Medical and Dental University Graduate School  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo 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