{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:19:33Z","timestamp":1761747573759,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T00:00:00Z","timestamp":1407888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2015,3]]},"abstract":"\n Objective<\/jats:title>\n \n To investigate the diagnostic performance and safety of a three\u2010dimensional 14\u2010core biopsy (\n 3D14PBx<\/jats:styled-content>\n ) method, which is a combination of the transrectal six\u2010core and transperineal eight\u2010core biopsy methods.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n Between\n D<\/jats:styled-content>\n ecember 2005 and\n A<\/jats:styled-content>\n ugust 2010, 1103 men underwent\n 3D14PBx<\/jats:styled-content>\n at our institutions and were analysed prospectively. Biopsy criteria included a\n PSA<\/jats:styled-content>\n level of 2.5\u201320\u2009ng\/mL or abnormal digital rectal examination (\n DRE<\/jats:styled-content>\n ) findings, or both. The primary endpoint of the study was diagnostic performance and the secondary endpoint was safety. We applied recursive partitioning to the entire study cohort to delineate the unique contribution of each sampling site to overall and clinically significant cancer detection.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Prostate cancer was detected in 503 of the 1103 patients (45.6%). Age, family history of prostate cancer,\n DRE<\/jats:styled-content>\n ,\n PSA<\/jats:styled-content>\n , percentage of free\n PSA<\/jats:styled-content>\n and prostate volume were associated with the positive biopsy results significantly and independently. Of the 503 cancers detected, 39 (7.8%) were clinically locally advanced (\u2265\n cT3a<\/jats:styled-content>\n ), 348 (69%) had a biopsy Gleason score (\n GS<\/jats:styled-content>\n ) of \u22657, and 463 (92%) met the definition of biopsy\u2010based significant cancer. Recursive partitioning analysis showed that each sampling site contributed uniquely to both the overall and the biopsy\u2010based significant cancer detection rate of the 3D14PBx method. The overall cancer\u2010positive rate of each sampling site ranged from 14.5% in the transrectal far lateral base to 22.8% in the transrectal far lateral apex. As of\n A<\/jats:styled-content>\n ugust 2010, 210 patients (42%) had undergone radical prostatectomy, of whom 55 (26%) were found to have pathologically non\u2010organ\u2010confined disease, 174 (83%) had prostatectomy\n GS<\/jats:styled-content>\n \u22657 and 185 (88%) met the definition of prostatectomy\u2010based significant cancer.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This is the first prospective analysis of the diagnostic performance of an extended biopsy method, which is a simplified version of the somewhat redundant super\u2010extended three\u2010dimensional 26\u2010core biopsy. As expected, each sampling site uniquely contributed not only to overall cancer detection, but also to significant cancer detection.\n 3D14PBx<\/jats:styled-content>\n is a feasible systematic biopsy method in men with\n PSA<\/jats:styled-content>\n <20\u2009ng\/mL.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12772","type":"journal-article","created":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T04:20:54Z","timestamp":1397535654000},"page":"412-418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Diagnostic performance and safety of a three\u2010dimensional 14\u2010core systematic biopsy method"],"prefix":"10.1111","volume":"115","author":[{"given":"Hideki","family":"Takeshita","sequence":"first","affiliation":[{"name":"Department of Urology Tokyo Medical and Dental University Graduate School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical and Dental University Graduate School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Numao","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical and Dental University Graduate School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizuaki","family":"Sakura","sequence":"additional","affiliation":[{"name":"Department of Urology Cancer Institute Hospital Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Tatokoro","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical and Dental University Graduate School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Urology Cancer Institute Hospital Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Kijima","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical and Dental University Graduate School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Komai","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical and Dental University Graduate School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical and Dental University Graduate School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumitaka","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical and Dental University Graduate School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhisa","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical and Dental University Graduate School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwao","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Urology Cancer Institute Hospital Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Kihara","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Medical and Dental University Graduate School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.09.033"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.10.009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.04.043"},{"key":"e_1_2_6_5_1","unstructured":"HeidenreichA BastianPJ BellmuntJet\u2009al.EAU guidelines on Prostate Cancer 2013. 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