{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:03:07Z","timestamp":1773493387966,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T00:00:00Z","timestamp":1407715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"MAPP research grant","award":["NIH DK082315"],"award-info":[{"award-number":["NIH DK082315"]}]},{"DOI":"10.13039\/100007338","name":"Barnes-Jewish Hospital Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007338","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2014,12]]},"abstract":"\n Objectives<\/jats:title>\n \n To describe the full range of symptom exacerbations defined by people with interstitial cystitis\/bladder pain syndrome and chronic prostatitis\/chronic pelvic pain syndrome as \u2018flares\u2019, and to investigate their associated healthcare utilization and bother at two sites of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (\n MAPP<\/jats:styled-content>\n ) Epidemiology and Phenotyping study.\n <\/jats:p>\n <\/jats:sec>\n \n Subjects and Methods<\/jats:title>\n \n Participants completed a flare survey that asked them: 1) whether they had ever had flares (\u2018symptoms that are much worse than usual\u2019) that lasted <1\u2009h, >1\u2009h and <1 day, and >1 day; and 2) for each duration of flare, to report: their average length and frequency; their typical levels of urological and pelvic pain symptoms; and their levels of healthcare utilization and bother. We compared participants' responses to their non\u2010flare\n MAPP<\/jats:styled-content>\n values and by duration of flare using generalized linear mixed models.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of 85 participants, 76 (89.4%) completed the flare survey, 72 (94.7%) of whom reported experiencing flares. Flares varied widely in terms of their duration (seconds to months), frequency (several times per day to once per year or less), and intensity and type of symptoms (e.g. pelvic pain vs urological symptoms). Flares of all durations were associated with greater pelvic pain, urological symptoms, disruption to participants' activities and bother, with increasing severity of each of these factors as the duration of flares increased. Days\u2010long flares were also associated with greater healthcare utilization. In addition to duration, symptoms (pelvic pain, in particular) were also significant determinants of flare\u2010related bother.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Our findings suggest that flares are common and associated with greater symptoms, healthcare utilization, disruption and bother. Our findings also show the characteristics of flares most bothersome to patients (i.e. increased pelvic pain and duration), and thus of greatest importance to consider in future research on flare prevention and treatment.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12778","type":"journal-article","created":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T04:21:05Z","timestamp":1397535665000},"page":"916-925","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Urological chronic pelvic pain syndrome symptom flares: characterisation of the full range of flares at two sites in the\n M<\/scp>\n ultidisciplinary\n A<\/scp>\n pproach to the\n S<\/scp>\n tudy of\n C<\/scp>\n hronic\n P<\/scp>\n elvic\n P<\/scp>\n ain (\n MAPP<\/scp>\n ) Research Network"],"prefix":"10.1111","volume":"114","author":[{"given":"Siobhan","family":"Sutcliffe","sequence":"first","affiliation":[{"name":"Division of Public Health Sciences Department of Surgery Washington University School of Medicine St. Louis MO USA"},{"name":"Alvin J. Siteman Cancer Center Department of Surgery Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham A.","family":"Colditz","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences Department of Surgery Washington University School of Medicine St. Louis MO USA"},{"name":"Alvin J. Siteman Cancer Center Department of Surgery Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melody S.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences Department of Surgery Washington University School of Medicine St. Louis MO USA"},{"name":"Alvin J. Siteman Cancer Center Department of Surgery Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ratna","family":"Pakpahan","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences Department of Surgery Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Vetter","sequence":"additional","affiliation":[{"name":"Division of Urologic Surgery Department of Surgery Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy J.","family":"Ness","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology University of Alabama at Birmingham Birmingham AL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald L.","family":"Andriole","sequence":"additional","affiliation":[{"name":"Alvin J. Siteman Cancer Center Department of Surgery Washington University School of Medicine St. Louis MO USA"},{"name":"Division of Urologic Surgery Department of Surgery Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Henry","family":"Lai","sequence":"additional","affiliation":[{"name":"Division of Urologic Surgery Department of Surgery Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0094-0143(21)00601-7","article-title":"Self\u2010care regimens for patients with interstitial cystitis","volume":"21","author":"Whitmore KE","year":"1994","journal-title":"Urol Clin North Am"},{"key":"e_1_2_7_3_1","first-page":"1199","article-title":"Interstitial cystitis: urgency and frequency syndrome","volume":"64","author":"Metts JF","year":"2001","journal-title":"Am Fam Physician"},{"key":"e_1_2_7_4_1","unstructured":"HannoPM BurksDA ClemensJQet\u2009al.American Urological Association (AUA) guideline: diagnosis and treatment of interstitial cystitis\/bladder pain syndrome. 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