{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T16:19:07Z","timestamp":1761754747867,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T00:00:00Z","timestamp":1428278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001026","name":"National Breast Cancer Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001026","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001111","name":"Cancer Australia","doi-asserted-by":"crossref","award":["#628333"],"award-info":[{"award-number":["#628333"]}],"id":[{"id":"10.13039\/501100001111","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Health and Medical Research Council (NHMRC)"},{"name":"Queensland Cancer Fund"},{"name":"Cancer Councils of New South Wales, Victoria, Tasmania and South Australia"},{"DOI":"10.13039\/501100001170","name":"Cancer Foundation of Western Australia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001170","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2015,8]]},"abstract":"\n Objective<\/jats:title>\n \n To ascertain whether\n D<\/jats:styled-content>\n '\n A<\/jats:styled-content>\n mico risk classification is an accurate discriminator of prostate cancer mortality risk in\n \n BRCA<\/jats:styled-content>\n 2\n <\/jats:italic>\n pathogenic mutation carriers and non\u2010carriers from a familial breast cancer cohort.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n From family cancer pedigrees of patients evaluated through a familial breast cancer cohort all related men with a diagnosis of prostate cancer were identified. Genotyping of each patient or of the dominant familial\n \n BRCA<\/jats:styled-content>\n 2\n <\/jats:italic>\n mutation was undertaken in each instance. Prostate cancers were analysed by\n \n BRCA<\/jats:styled-content>\n 2\n <\/jats:italic>\n carrier vs non\u2010carrier status for their clinical progression and survival according to their\n D<\/jats:styled-content>\n 'Amico risk groups.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n For patients who were\n \n BRCA<\/jats:styled-content>\n 2\n <\/jats:italic>\n \u2010mutation positive, there was no significant difference in cancer\u2010specific survival (\n CSS<\/jats:styled-content>\n ) between those patients who were graded as having\n D<\/jats:styled-content>\n '\n A<\/jats:styled-content>\n mico high\u2010 or intermediate\u2010risk disease. For patients who were\n \n BRCA<\/jats:styled-content>\n 2\n <\/jats:italic>\n \u2010mutation negative, but were identified via a family cancer pedigree, there was no statistically significant difference in\n CSS<\/jats:styled-content>\n between\n D<\/jats:styled-content>\n '\n A<\/jats:styled-content>\n mico high\u2010 and intermediate\u2010risk prostate cancers. Patients with\n D<\/jats:styled-content>\n '\n A<\/jats:styled-content>\n mico high\u2010risk disease who were\n \n BRCA<\/jats:styled-content>\n 2\n <\/jats:italic>\n \u2010mutation carriers had substantially increased disease\u2010specific mortality compared with high\u2010risk non\u2010carriers (hazard ratio 2.94,\n P<\/jats:italic>\n = 0.004).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n D'Amico risk classification has limitations in predicting variations in prostate cancer\u2010specific mortality for this group of patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12792","type":"journal-article","created":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T07:45:27Z","timestamp":1398843927000},"page":"207-212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Altered significance of\n D<\/scp>\n '\n A<\/scp>\n mico risk classification in patients with prostate cancer linked to a familial breast cancer (k\n C<\/scp>\n on\n F<\/scp>\n ab) cohort"],"prefix":"10.1111","volume":"116","author":[{"given":"Damien","family":"Bolton","sequence":"first","affiliation":[{"name":"kConFab, Research Department Peter MacCallum Cancer Centre East Melbourne Australia"},{"name":"Department of Urology University of Melbourne Austin Hospital Heidelberg Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Cheng","sequence":"additional","affiliation":[{"name":"kConFab, Research Department Peter MacCallum Cancer Centre East Melbourne Australia"},{"name":"Department of Urology University of Melbourne Austin Hospital Heidelberg Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber J.","family":"Willems\u2010Jones","sequence":"additional","affiliation":[{"name":"kConFab, Research Department Peter MacCallum Cancer Centre East Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Li","sequence":"additional","affiliation":[{"name":"Bioinformatics, Research Department Peter MacCallum Cancer Centre East Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eveline","family":"Niedermeyr","sequence":"additional","affiliation":[{"name":"kConFab, Research Department Peter MacCallum Cancer Centre East Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Familial Cancer Centre Peter MacCallum Cancer Centre East Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Clouston","sequence":"additional","affiliation":[{"name":"Tissupath Mt. Waverley Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Lawrentschuk","sequence":"additional","affiliation":[{"name":"Department of Urology University of Melbourne Austin Hospital Heidelberg Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ania","family":"Sliwinski","sequence":"additional","affiliation":[{"name":"kConFab, Research Department Peter MacCallum Cancer Centre East Melbourne Australia"},{"name":"Department of Urology University of Melbourne Austin Hospital Heidelberg Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Fox","sequence":"additional","affiliation":[{"name":"Pathology Department Peter MacCallum Cancer Centre East Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Thorne","sequence":"additional","affiliation":[{"name":"kConFab, Research Department Peter MacCallum Cancer Centre East Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.15.1310"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/378789a0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.05.055"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705153362001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/513891"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0397"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001090050162"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604453"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-2871"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605822"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2010.0010"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.11.061"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.11.969"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1377"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-008-0250-7"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20855"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbju.12792","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.12792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T16:14:30Z","timestamp":1761754470000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.12792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,6]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/bju.12792"],"URL":"https:\/\/doi.org\/10.1111\/bju.12792","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"type":"print","value":"1464-4096"},{"type":"electronic","value":"1464-410X"}],"subject":[],"published":{"date-parts":[[2015,4,6]]},"assertion":[{"value":"2015-04-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}