{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:52:55Z","timestamp":1780087975510,"version":"3.54.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T00:00:00Z","timestamp":1407715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2015,4]]},"abstract":"\n Objective<\/jats:title>\n \n To explore preferences in the management of patients with newly diagnosed high\u2010risk prostate cancer (\n PCa<\/jats:styled-content>\n ) among urologists in Europe through a web\u2010based survey.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n A web\u2010based survey was conducted between 15\n A<\/jats:styled-content>\n ugust and 15\n S<\/jats:styled-content>\n eptember 2013 by members of the Prostate Cancer Working Group of the Young Academic Urologists Working Party of the European Association of Urology (\n EAU<\/jats:styled-content>\n ). A specific, 29\u2010item multiple\u2010choice questionnaire covering the whole spectrum of diagnosis, staging and treatment of high\u2010risk\n PCa<\/jats:styled-content>\n was e\u2010mailed to all urologists included in the mailing list of\n EAU<\/jats:styled-content>\n members.\n E<\/jats:styled-content>\n urope was divided into four geographical regions:\n C<\/jats:styled-content>\n entral\u2010\n E<\/jats:styled-content>\n astern\n E<\/jats:styled-content>\n urope (\n CEE<\/jats:styled-content>\n ),\n N<\/jats:styled-content>\n orthern\n E<\/jats:styled-content>\n urope (\n NE<\/jats:styled-content>\n ),\n S<\/jats:styled-content>\n outhern\n E<\/jats:styled-content>\n urope (\n SE<\/jats:styled-content>\n ) and\n W<\/jats:styled-content>\n estern\n E<\/jats:styled-content>\n urope (\n WE<\/jats:styled-content>\n ). Descriptive statistics were used. Differences among sample segments were obtained from a z\u2010test compared with the total sample.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the 12\u2009850 invited\n EAU<\/jats:styled-content>\n members, 585 urologists practising in\n E<\/jats:styled-content>\n urope completed the survey. High\u2010risk\n PCa<\/jats:styled-content>\n was defined as serum\n PSA<\/jats:styled-content>\n \u226520\u2009ng\/mL or clinical stage \u2265\n T3<\/jats:styled-content>\n or biopsy Gleason score \u2265 8 by 67% of responders, without significant geographical variations. The preferred single\u2010imaging examinations for staging were bone scan (74%, 81% in\n WE<\/jats:styled-content>\n and 70% in\n SE<\/jats:styled-content>\n ;\n P<\/jats:italic>\n = 0.02 for both), magnetic resonance imaging (53%, 72% in\n WE<\/jats:styled-content>\n and 40% in\n SE<\/jats:styled-content>\n ;\n P<\/jats:italic>\n = 0.02 and\n P<\/jats:italic>\n = 0.01, respectively) and computed tomography (45%, 60% in\n SE<\/jats:styled-content>\n and 23% in\n WE<\/jats:styled-content>\n ;\n P<\/jats:italic>\n = 0.01 for both). Pre\u2010treatment predictive tools were routinely used by 62% of the urologists, without significant geographical variations. The preferred treatment was radical prostatectomy as the initial step of a multiple\u2010treatment approach (60%, 40% in\n NE<\/jats:styled-content>\n and 70% in\n CEE<\/jats:styled-content>\n ;\n P<\/jats:italic>\n = 0.02 and\n P<\/jats:italic>\n < 0.01, respectively), followed by external beam radiation therapy with androgen deprivation therapy (29%, 45% in\n NE<\/jats:styled-content>\n and 20% in\n CEE<\/jats:styled-content>\n ;\n P<\/jats:italic>\n = 0.01 and\n P<\/jats:italic>\n = 0.02, respectively), and radical prostatectomy as monotherapy (4%, 7% in\n WE<\/jats:styled-content>\n ;\n P<\/jats:italic>\n = 0.04). When surgery was performed, the open retropubic approach was the most popular (58%, 74% in\n CEE<\/jats:styled-content>\n , 37% in\n NE<\/jats:styled-content>\n ;\n P<\/jats:italic>\n < 0.01 for both). Pelvic lymph node dissection was performed by 96% of urologists, equally split between a standard and extended template. There was no consensus on the definition of disease recurrence after primary treatment, and much heterogeneity in the administration of adjuvant and salvage treatments.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n With the limitation of a low response rate, the present study is the first survey evaluating preferences in the management of high\u2010risk\n PCa<\/jats:styled-content>\n among urologists in\n E<\/jats:styled-content>\n urope. Although the definition of high\u2010risk\n PCa<\/jats:styled-content>\n was fairly uniform, wide variations in patterns of primary and adjuvant\/salvage treatments were observed. These differences might translate into variations in quality of care with a possible impact on ultimate oncological outcome.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12796","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T23:06:59Z","timestamp":1399417619000},"page":"571-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Preferences in the management of high\u2010risk prostate cancer among urologists in\n E<\/scp>\n urope: results of a web\u2010based survey"],"prefix":"10.1111","volume":"115","author":[{"given":"Cristian I.","family":"Surcel","sequence":"first","affiliation":[{"name":"Centre of Uronephrology and Renal Transplantation Fundeni Clinical Institute \u201cCarol Davila\u201d University of Medicine and Pharmacy Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanna","family":"Sooriakumaran","sequence":"additional","affiliation":[{"name":"Surgical Intervention Trials Unit Nuffield Department of Surgical Sciences University of Oxford Oxford UK"},{"name":"Department of Molecular Medicine and Surgery Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Briganti","sequence":"additional","affiliation":[{"name":"Department of Urology Urological Research Institute Vita\u2010Salute University San Raffaele Milan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter J.L.","family":"De Visschere","sequence":"additional","affiliation":[{"name":"Department of Radiology Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen J.","family":"F\u00fctterer","sequence":"additional","affiliation":[{"name":"Department of Radiology Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirus","family":"Ghadjar","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Charit\u00e9 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Isbarn","sequence":"additional","affiliation":[{"name":"Department of Urology University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piet","family":"Ost","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Experimental Cancer Research Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Ploussard","sequence":"additional","affiliation":[{"name":"Department of Urology CHU Saint\u2010Louis Assistance Publique \u2013 H\u00f4pitaux de Paris Universit\u00e9 Paris Est Creteil Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roderick C.N.","family":"van den Bergh","sequence":"additional","affiliation":[{"name":"Department of Urology University Medical Centre Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge M.","family":"van Oort","sequence":"additional","affiliation":[{"name":"Department of Urology Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Yossepowitch","sequence":"additional","affiliation":[{"name":"Department of Urology Rabin Medical Center \u2013 Beilinson Petach\u2010Tikva Israel"},{"name":"Sackler Faculty of Medicine University of Tel Aviv Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.P. 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