{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:51:19Z","timestamp":1780386679777,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T00:00:00Z","timestamp":1418601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2015,4]]},"abstract":"\n Objective<\/jats:title>\n \n To report the urinary toxicity outcomes for patients at greater risk of voiding symptoms and retention who received a modified limited transurethral resection of the prostate (\n TURP<\/jats:styled-content>\n ) before low\u2010dose rate (\n LDR<\/jats:styled-content>\n ) brachytherapy.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Method<\/jats:title>\n \n Data were analysed from patients receiving the above procedures between 2006 to present, taken from the prospective brachytherapy database of 2000 patients at the\n S<\/jats:styled-content>\n t.\n L<\/jats:styled-content>\n uke's\n C<\/jats:styled-content>\n ancer\n C<\/jats:styled-content>\n entre. The limited\n TURP<\/jats:styled-content>\n (\n \n TURP\n BXT<\/jats:sup>\n <\/jats:styled-content>\n ) was performed at a median (range) of 64 (25\u2013205) days before seed implantation with a median resection weight of 1.15\u2009g. Selection criteria were based on patients with moderate lower urinary tract symptoms, poor flow or post\u2010void residual urine volume (\n PVR<\/jats:styled-content>\n ), or a prominent middle lobe or high bladder neck on transrectal ultrasonography. Baseline prostate cancer characteristics, uroflowmetry,\n I<\/jats:styled-content>\n nternational\n P<\/jats:styled-content>\n rostate\n S<\/jats:styled-content>\n ymptom\n S<\/jats:styled-content>\n core (\n IPSS<\/jats:styled-content>\n ) and quality\u2010of\u2010life\n QoL<\/jats:styled-content>\n scores were collected and compared with follow\u2010up\n IPSS<\/jats:styled-content>\n and\n QoL<\/jats:styled-content>\n scores.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Data for 112 patients was gathered from the database. The\n \n TURP\n BXT<\/jats:sup>\n <\/jats:styled-content>\n resulted in statistically significant improvements before\n LDR<\/jats:styled-content>\n brachytherapy in maximum urinary flow rate (\n Q<\/jats:styled-content>\n max<\/jats:sub>\n ) and\n PVR<\/jats:styled-content>\n ,\n IPSS<\/jats:styled-content>\n and\n QoL<\/jats:styled-content>\n scores (the mean\n Q<\/jats:styled-content>\n max<\/jats:sub>\n before vs after the\n \n TURP\n BXT<\/jats:sup>\n <\/jats:styled-content>\n was 11.3 vs 16.7\u2009mL\/s). The\n IPSS<\/jats:styled-content>\n and\n QoL<\/jats:styled-content>\n scores at 6 months after seed implantation were increased compared with baseline values before the\n \n TURP\n BXT<\/jats:sup>\n <\/jats:styled-content>\n (mean\n IPSS<\/jats:styled-content>\n at 6 months 11.7 vs 9.2 before\n \n TURP\n BXT<\/jats:sup>\n <\/jats:styled-content>\n ), but no difference at 1 year (mean\n IPSS<\/jats:styled-content>\n 9), and improved scores at 2, 3, 4 and 5 years follow\u2010up (mean\n IPSS<\/jats:styled-content>\n of 7.9, 5.6, 5.3 and 7.4, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The present study suggests patients at increased risk of deteriorating voiding symptoms, including urinary retention, are no longer contraindicated against\n LDR<\/jats:styled-content>\n brachytherapy if they receive a modified\n TURP<\/jats:styled-content>\n before seed implantation. This procedure does not appear to carry the risk of urinary incontinence thought to be associated with a conventional\n TURP<\/jats:styled-content>\n before\n LDR<\/jats:styled-content>\n brachytherapy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12798","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T23:07:03Z","timestamp":1399417623000},"page":"580-586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Modified transurethral resection of the prostate (\n TURP<\/scp>\n ) for men with moderate lower urinary tract symptoms (\n LUTS<\/scp>\n ) before brachytherapy is safe and feasible"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0743-9449","authenticated-orcid":false,"given":"Philip","family":"Brousil","sequence":"first","affiliation":[{"name":"St. Luke's Cancer Centre The Royal Surrey County Hospital NHS Foundation Trust Guildford Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muddassar","family":"Hussain","sequence":"additional","affiliation":[{"name":"St. Luke's Cancer Centre The Royal Surrey County Hospital NHS Foundation Trust Guildford Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lynch","sequence":"additional","affiliation":[{"name":"St. Luke's Cancer Centre The Royal Surrey County Hospital NHS Foundation Trust Guildford Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Laing","sequence":"additional","affiliation":[{"name":"St. Luke's Cancer Centre The Royal Surrey County Hospital NHS Foundation Trust Guildford Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen E.M.","family":"Langley","sequence":"additional","affiliation":[{"name":"St. Luke's Cancer Centre The Royal Surrey County Hospital NHS Foundation Trust Guildford Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,15]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"UK Office for National Statistics.Cancer Statistics Registrations England(Series MB1) No. 41 2010. 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