{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:23:50Z","timestamp":1761765830947,"version":"build-2065373602"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T00:00:00Z","timestamp":1411603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["K07CA178258","P50CA090386","2R01CA089600"],"award-info":[{"award-number":["K07CA178258","P50CA090386","2R01CA089600"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Urological Research Foundation"},{"name":"NorthShore University Health System"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2015,1]]},"abstract":"\n Objective<\/jats:title>\n \n To assess the frequency of a novel prostate cancer\u2010associated single nucleotide polymorphism (\n SNP<\/jats:styled-content>\n ), rs188140481, in a\n N<\/jats:styled-content>\n orth\n A<\/jats:styled-content>\n merican population and to evaluate the clinical significance of this variant including annotated prostatectomy pathology.\n <\/jats:p>\n <\/jats:sec>\n \n Patients\/Subjects and Methods<\/jats:title>\n \n We examined the frequency of the minor allele at rs188140481 in 4299\n N<\/jats:styled-content>\n orth\n A<\/jats:styled-content>\n merican men including 1979 men with prostate cancer and 2320 healthy volunteers. We compared the clinicopathological features of prostate cancer between carriers and non\u2010carriers of the\n SNP<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The rs188140481[\n A<\/jats:styled-content>\n ]\n SNP<\/jats:styled-content>\n was present in 1.6% of the cohort; it was significantly more likely to be carried by men with prostate cancer than healthy controls (odds ratio 3.14; 95% confidence interval [\n CI<\/jats:styled-content>\n ] 1.85\u20135.35). After adjusting for age and\n PSA<\/jats:styled-content>\n levels, carriers were found to be 6.73\u2010fold (95%\n CI<\/jats:styled-content>\n 1.69\u201326.76) more likely to develop prostate cancer than non\u2010carriers. Age at diagnosis, frequency of a positive family history of prostate cancer, and biochemical recurrence rates were similar between\n SNP<\/jats:styled-content>\n carriers and non\u2010carriers. Patients with the\n SNP<\/jats:styled-content>\n had a proportionately higher frequency of stage \u2265T2c disease (29.5% vs 20.1%;\n P<\/jats:italic>\n = 0.13), Gleason \u22658 tumours (13.3% vs 6.5%;\n P<\/jats:italic>\n = 0.10), and extracapsular extension (28.9% vs 18.8%;\n P<\/jats:italic>\n = 0.12) compared with non\u2010carriers.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n rs188140481[\n A<\/jats:styled-content>\n ] is a rare\n SNP<\/jats:styled-content>\n that confers greater risk of prostate cancer compared with\n SNPs<\/jats:styled-content>\n identified by genome\u2010wide association studies. Because of its low frequency, larger studies are needed to validate the prognostic significance of this locus, and associations with adverse pathology.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12847","type":"journal-article","created":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T08:26:08Z","timestamp":1403252768000},"page":"101-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A rare 8q24 single nucleotide polymorphism (\n SNP<\/scp>\n ) predisposes\n N<\/scp>\n orth\n A<\/scp>\n merican men to prostate cancer and possibly more aggressive disease"],"prefix":"10.1111","volume":"115","author":[{"given":"Boris","family":"Grin","sequence":"first","affiliation":[{"name":"Department of Urology Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacy","family":"Loeb","sequence":"additional","affiliation":[{"name":"Department of Urology New York University New York City NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Roehl","sequence":"additional","affiliation":[{"name":"Department of Urology Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip R.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Urology Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Catalona","sequence":"additional","affiliation":[{"name":"Department of Urology Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian T.","family":"Helfand","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgery Northshore University HealthSystem John and Carol Walter Center for Urological Health Evanston IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21166"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21208"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2560"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21235"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1999"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa075819"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2015"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0312"},{"key":"e_1_2_7_10_1","unstructured":"HidorffLA MacArthurJ MoralesJet\u2009al.Catalog of published genome\u2010wide association studies. genome.gov. Available at:http:\/\/www.genome.gov\/gwastudies\/. Accessed June 2013"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2437"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110000"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2062"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbju.12847","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.12847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T11:04:02Z","timestamp":1761735842000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.12847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,25]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/bju.12847"],"URL":"https:\/\/doi.org\/10.1111\/bju.12847","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"type":"print","value":"1464-4096"},{"type":"electronic","value":"1464-410X"}],"subject":[],"published":{"date-parts":[[2014,9,25]]},"assertion":[{"value":"2014-09-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}