{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:08:52Z","timestamp":1770746932268,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T00:00:00Z","timestamp":1418601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2015,4]]},"abstract":"\n Objectives<\/jats:title>\n \n To review outcomes of the treatment of carcinoma\n in situ<\/jats:italic>\n (\n CIS<\/jats:styled-content>\n ) of the penis at a large supra\u2010regional penile cancer network, where centralisation has permitted greater experience with treatment outcomes, and suggest treatment strategies.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n The network penile cancer database, which details presentation, treatment and complications was analysed from 2003 to 2010, identifying patients with\n CIS<\/jats:styled-content>\n , with a minimum follow\u2010up of 2 years, looking at treatments administered and outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In all, 57 patients with mean (range) age of 61 (34\u201391) years were identified. In all, 18 were treated by circumcision only, 20 by circumcision and local excision (\n LE<\/jats:styled-content>\n ) and 19 by circumcision and 5\u2010flurouracil (5\u2010\n FU<\/jats:styled-content>\n ). The mean (range) follow\u2010up was 3.5 (2\u20138) years. Of those treated by circumcision none subsequently developed\n CIS<\/jats:styled-content>\n on the glans. For those who underwent circumcision +\n LE<\/jats:styled-content>\n , five of 20 (25%) developed recurrence requiring further treatment. Of those treated by circumcision + 5\u2010\n FU<\/jats:styled-content>\n , 14\/19 (73.7%) completely responded. Of the five incomplete responders, two had focal invasive malignancy at repeat biopsy. One incomplete responder underwent glansectomy and four grafting. No complete responders relapsed. Complications of 5\u2010\n FU<\/jats:styled-content>\n included significant inflammatory response in seven (36.8%), with two requiring hospital admission and one neo\u2010phimosis (5.3%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This study suggests that patients undergoing circumcision for isolated\n CIS<\/jats:styled-content>\n and complete responders to 5\u2010\n FU<\/jats:styled-content>\n may require only short\u2010term follow\u2010up, as recurrence is unlikely, whereas longer follow up is required for all other patients. However, numbers in this study are small and larger studies are needed to support this. An incomplete response to 5\u2010\n FU<\/jats:styled-content>\n dictates immediate re\u2010biopsy, as it carries a significant chance of previously undetected invasive disease.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12878","type":"journal-article","created":{"date-parts":[[2014,7,25]],"date-time":"2014-07-25T05:04:02Z","timestamp":1406264642000},"page":"595-598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The treatment of penile carcinoma\n in situ<\/i>\n (\n CIS<\/scp>\n ) within a\n UK<\/scp>\n supra\u2010regional network"],"prefix":"10.1111","volume":"115","author":[{"given":"Marc","family":"Lucky","sequence":"first","affiliation":[{"name":"Wirral University Teaching Hospital NHS Foundation Trust Wirral Merseyside UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kusuma V.R.","family":"Murthy","sequence":"additional","affiliation":[{"name":"The Christie NHS Foundation Trust, Withington Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beverley","family":"Rogers","sequence":"additional","affiliation":[{"name":"Wirral University Teaching Hospital NHS Foundation Trust Wirral Merseyside UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Jones","sequence":"additional","affiliation":[{"name":"Wirral University Teaching Hospital NHS Foundation Trust Wirral Merseyside UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurice W.","family":"Lau","sequence":"additional","affiliation":[{"name":"The Christie NHS Foundation Trust, Withington Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay K.","family":"Sangar","sequence":"additional","affiliation":[{"name":"The Christie NHS Foundation Trust, Withington Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel J.","family":"Parr","sequence":"additional","affiliation":[{"name":"Wirral University Teaching Hospital NHS Foundation Trust Wirral Merseyside UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)35099-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1980.tb01026.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2009.036061"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.09.039"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197312)32:6<1396::AID-CNCR2820320618>3.0.CO;2-T"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)61720-8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-011-9785-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1980.tb01026.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197610)38:4<1498::AID-CNCR2820380409>3.0.CO;2-#"},{"key":"e_1_2_6_11_1","volume-title":"The 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