{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T03:12:27Z","timestamp":1778987547245,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T00:00:00Z","timestamp":1433203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2015,12]]},"abstract":"\n Objective<\/jats:title>\n \n To determine the impact of prostate size on positive surgical margin (\n PSM<\/jats:styled-content>\n ) rates after robot\u2010assisted radical prostatectomy (\n RARP<\/jats:styled-content>\n ) and the preoperative factors associated with\n PSM<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n In all, 1229 men underwent\n RARP<\/jats:styled-content>\n by a single surgeon, from 2005 to\n A<\/jats:styled-content>\n ugust of 2013. Excluded were patients who had transurethral resection of the prostate, neoadjuvant therapy, clinically advanced cancer, and the first 200 performed cases (to reduce the effect of learning curve). Included were 815 patients who were then divided into three prostate size groups: <31\u2009g (group 1), 31\u201345\u2009g (group 2), >45\u2009g (group 3). Multivariate analysis determined predictors of\n PSM<\/jats:styled-content>\n and biochemical recurrence (\n BCR<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Console time and blood loss increased with increasing prostate size. There were more high\u2010grade tumours in group 1 (group 1 vs group 2 and group 3, 33.9% vs 25.1% and 25.6%,\n P<\/jats:italic>\n = 0.003 and\n P<\/jats:italic>\n = 0.005).\n PSM<\/jats:styled-content>\n rates were higher in prostates of <45\u2009g with preoperative\n PSA<\/jats:styled-content>\n levels of >20\u2009ng\/dL, Gleason score \u22657, T3 tumour, and \u22653 positive biopsy cores. In group 1, preoperative stage T3 [odds ratio (\n OR<\/jats:styled-content>\n ) 3.94,\n P<\/jats:italic>\n = 0.020] and \u22653 positive biopsy cores (\n OR<\/jats:styled-content>\n 2.52,\n P<\/jats:italic>\n = 0.043) were predictive of\n PSM<\/jats:styled-content>\n , while a\n PSA<\/jats:styled-content>\n level of >20\u2009ng\/dL predicted the occurrence of\n BCR<\/jats:styled-content>\n (\n OR<\/jats:styled-content>\n 5.34,\n P<\/jats:italic>\n = 0.021). No preoperative factors predicted\n PSM<\/jats:styled-content>\n or\n BCR<\/jats:styled-content>\n for groups 2 and 3.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n A preoperative biopsy with \u22653 positive cores in men with small prostates predicts\n PSM<\/jats:styled-content>\n after\n RARP<\/jats:styled-content>\n . In small prostates with\n PSM<\/jats:styled-content>\n , a\n PSA<\/jats:styled-content>\n level of >20\u2009ng\/dL is a predictor of\n BCR<\/jats:styled-content>\n . These factors should guide the choice of therapy and indicate the need for closer postoperative follow\u2010up.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12888","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T08:23:21Z","timestamp":1407399801000},"page":"897-904","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Number of positive preoperative biopsy cores is a predictor of positive surgical margins (\n PSM<\/scp>\n ) in small prostates after robot\u2010assisted radical prostatectomy (\n RARP<\/scp>\n )"],"prefix":"10.1111","volume":"116","author":[{"given":"Patrick H.","family":"Tuliao","sequence":"first","affiliation":[{"name":"Department of Urology and Urological Science Institute Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyo C.","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Urology and Urological Science Institute Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Komninos","sequence":"additional","affiliation":[{"name":"Department of Urology and Urological Science Institute Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien H.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Urology and Urological Science Institute Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young D.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Urology and Urological Science Institute Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung H.","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Urology and Urological Science Institute Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung J.","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Urology and Urological Science Institute Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koon H.","family":"Rha","sequence":"additional","affiliation":[{"name":"Department of Urology and Urological Science Institute Yonsei University College of Medicine Seoul Republic of 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