{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:04:29Z","timestamp":1773302669424,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T00:00:00Z","timestamp":1433203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Italian Health Minister"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2015,11]]},"abstract":"\n Objective<\/jats:title>\n \n To investigate the expression of two types of cation channels, \u03b3\n E<\/jats:styled-content>\n pithelial\n N<\/jats:styled-content>\n a\n +<\/jats:sup>\n C<\/jats:styled-content>\n hannel (\u03b3\n ENaC<\/jats:styled-content>\n ) and the\n A<\/jats:styled-content>\n cid\u2010\n S<\/jats:styled-content>\n ensing\n I<\/jats:styled-content>\n on\n C<\/jats:styled-content>\n hannel 1 (\n ASIC1<\/jats:styled-content>\n ), in the urothelium of controls and in patients affected by neurogenic detrusor overactivity (\n NDO<\/jats:styled-content>\n ). In parallel, urodynamic parameters were collected and correlated to the immunohistochemical results.\n <\/jats:p>\n <\/jats:sec>\n \n Patients Subjects and Methods<\/jats:title>\n \n Four controls and 12 patients with a clinical diagnosis of\n NDO<\/jats:styled-content>\n and suprasacral spinal cord lesion underwent urodynamic measurements and cystoscopy. Cold\u2010cup biopsies were frozen and processed for immunohistochemistry and\n W<\/jats:styled-content>\n estern\n B<\/jats:styled-content>\n lot. Spearman's correlation coefficient between morphological and urodynamic data was applied. One\u2010way\n anova<\/jats:sc>\n followed by\n N<\/jats:styled-content>\n ewman\u2013\n K<\/jats:styled-content>\n euls multiple comparison\n post hoc<\/jats:italic>\n test was applied for\n W<\/jats:styled-content>\n estern\n B<\/jats:styled-content>\n lot results.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In the controls, \u03b3\n ENaC<\/jats:styled-content>\n and\n ASIC1<\/jats:styled-content>\n were expressed in the urothelium with differences in their cell distribution and intensity. In patients with\n NDO<\/jats:styled-content>\n , both markers showed consistent changes either in cell distribution and labelling intensity compared with the controls. A significant correlation between a higher intensity of \u03b3\n ENaC<\/jats:styled-content>\n expression in the urothelium of patients with\n NDO<\/jats:styled-content>\n and lower values of bladder compliance was detected.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The present findings show important changes in the expression of \u03b3\n ENaC<\/jats:styled-content>\n and\n ASIC1<\/jats:styled-content>\n in\n NDO<\/jats:styled-content>\n human urothelium. Notably, while the changes in \u03b3\n ENaC<\/jats:styled-content>\n might impair the mechanosensory function of the urothelium, the increase of\n ASIC1<\/jats:styled-content>\n might represent an attempt to compensate for the excess in local sensitivity.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12896","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T18:08:59Z","timestamp":1422554939000},"page":"797-804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["\u03b3\n E<\/scp>\n pithelial\n N<\/scp>\n a\n +<\/sup>\n C<\/scp>\n hannel (\u03b3\n ENaC<\/scp>\n ) and the\n A<\/scp>\n cid\u2010\n S<\/scp>\n ensing\n I<\/scp>\n on\n C<\/scp>\n hannel 1 (\n ASIC1<\/scp>\n ) expression in the urothelium of patients with neurogenic detrusor overactivity"],"prefix":"10.1111","volume":"116","author":[{"given":"Chiara","family":"Traini","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine Histology and Embryology Research Unit University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Del Popolo","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Urology Careggi University Hospital Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Lazzeri","sequence":"additional","affiliation":[{"name":"Division of Oncology Unit of Urology URI IRCCS Ospedale San Raffaele Universit\u00e0 Vita\u2010Salute San Raffaele Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia","family":"Mazzaferro","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine Histology and Embryology Research Unit University of 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