{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T10:29:34Z","timestamp":1775730574038,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T00:00:00Z","timestamp":1427241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2015,4]]},"abstract":"\n Objectives<\/jats:title>\n \n To evaluate the performance of multiparametric magnetic resonance imaging (\n mpMRI<\/jats:styled-content>\n ) in predicting prostate cancer on repeat biopsy; and to compare the cancer detection rates (\n CDR<\/jats:styled-content>\n s) of\n MRI<\/jats:styled-content>\n \/transrectal ultrasonography (\n TRUS<\/jats:styled-content>\n ) fusion\u2010guided biopsy with standard 12\u2010core biopsy in men with at least one previous negative biopsy.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n We prospectively enrolled men with elevated or rising\n PSA<\/jats:styled-content>\n levels and\/or abnormal digital rectal examination into our\n MRI<\/jats:styled-content>\n \/\n TRUS<\/jats:styled-content>\n fusion\u2010guided prostate biopsy trial. Participants underwent a 3 T mpMRI with an endorectal coil. Three radiologists graded all suspicious lesions on a 5\u2010point Likert scale.\n MRI<\/jats:styled-content>\n \/\n TRUS<\/jats:styled-content>\n fusion\u2010guided biopsies of suspicious prostate lesions and standard\n TRUS<\/jats:styled-content>\n \u2010guided 12\u2010core biopsies were performed. Analysis of 140 eligible men with at least one previous negative biopsy was performed. We calculated\n CDR<\/jats:styled-content>\n s and estimated area under the receiver operating characteristic curves (\n AUC<\/jats:styled-content>\n s) of\n mpMRI<\/jats:styled-content>\n in predicting any cancer and clinically significant prostate cancer.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The overall\n CDR<\/jats:styled-content>\n was 65.0% (91\/140). Higher level of suspicion on\n mpMRI<\/jats:styled-content>\n was significantly associated with prostate cancer detection (\n P<\/jats:italic>\n < 0.001) with an\n AUC<\/jats:styled-content>\n of 0.744 compared with 0.653 and 0.680 for\n PSA<\/jats:styled-content>\n level and\n PSA<\/jats:styled-content>\n density, respectively. The\n CDR<\/jats:styled-content>\n s of\n MRI<\/jats:styled-content>\n \/\n TRUS<\/jats:styled-content>\n fusion\u2010guided and standard 12\u2010core biopsy were 52.1% (73\/140) and 48.6% (68\/140), respectively (\n P<\/jats:italic>\n = 0.435). However, fusion biopsy was more likely to detect clinically significant prostate cancer when compared with the 12\u2010core biopsy (47.9% vs 30.7%;\n P<\/jats:italic>\n < 0.001). Of the cancers missed by 12\u2010core biopsy, 20.9% (19\/91) were clinically significant. Most cancers missed by 12\u2010core biopsy (69.6%) were located in the anterior fibromuscular stroma and transition zone. Using a fusion\u2010biopsy\u2010only approach in men with an\n MRI<\/jats:styled-content>\n suspicion score of \u22654 would have missed only 3.5% of clinically significant prostate cancers.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Using\n mpMRI<\/jats:styled-content>\n and subsequent\n MRI<\/jats:styled-content>\n \/\n TRUS<\/jats:styled-content>\n fusion\u2010guided biopsy platform may improve detection of clinically significant prostate cancer in men with previous negative biopsies. Addition of a 12\u2010core biopsy may be needed to avoid missing some clinically significant prostate cancers.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12938","type":"journal-article","created":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T08:11:44Z","timestamp":1411459904000},"page":"562-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":117,"title":["In patients with a previous negative prostate biopsy and a suspicious lesion on magnetic resonance imaging, is a 12\u2010core biopsy still necessary in addition to a targeted biopsy?"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7461-7079","authenticated-orcid":false,"given":"Simpa S.","family":"Salami","sequence":"first","affiliation":[{"name":"The Arthur Smith Institute for Urology Hofstra North Shore\u2010LIJ School of Medicine New Hyde Park NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eran","family":"Ben\u2010Levi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Hofstra North Shore\u2010LIJ School of Medicine New Hyde Park NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana","family":"Yaskiv","sequence":"additional","affiliation":[{"name":"Department of Pathology Hofstra North Shore\u2010LIJ School of Medicine New Hyde Park NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Ryniker","sequence":"additional","affiliation":[{"name":"The Arthur Smith Institute for Urology Hofstra North Shore\u2010LIJ School of Medicine New Hyde Park NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baris","family":"Turkbey","sequence":"additional","affiliation":[{"name":"Molecular Imaging Program National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis R.","family":"Kavoussi","sequence":"additional","affiliation":[{"name":"The Arthur Smith Institute for Urology Hofstra North Shore\u2010LIJ School of Medicine New Hyde Park NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Villani","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Hofstra North Shore\u2010LIJ School of Medicine New Hyde Park NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ardeshir R.","family":"Rastinehad","sequence":"additional","affiliation":[{"name":"The Arthur Smith Institute for Urology Hofstra North Shore\u2010LIJ School of Medicine New Hyde Park NY USA"},{"name":"Department of Diagnostic and Interventional Radiology Hofstra North Shore\u2010LIJ School of Medicine New Hyde Park NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64999-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.12.014"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.06.071"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj131"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67711-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21420"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057480"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)64518-X"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2011.02798.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.05.078"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.12.007"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.10.048"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2013.06.007"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.08.025"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.04.119"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f7524"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2377-y"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510290050036"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28373"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.06.057"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.11.015"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.19.1542"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2011.04.001"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.09.011"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.06.098"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198812000-00001"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.10.076"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28790"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.08.195"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-014-1334-1"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.07.098"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12892"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbju.12938","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.12938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T11:56:00Z","timestamp":1761738960000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.12938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,25]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/bju.12938"],"URL":"https:\/\/doi.org\/10.1111\/bju.12938","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,25]]},"assertion":[{"value":"2015-03-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}