{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:17:29Z","timestamp":1789996649038,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,5,24]],"date-time":"2015-05-24T00:00:00Z","timestamp":1432425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2015,10]]},"abstract":"\n Objective<\/jats:title>\n \n To investigate whether diacylglycerol kinase \u03ba (\n DGKK<\/jats:styled-content>\n ) is a susceptibility gene for hypospadias in the\n H<\/jats:styled-content>\n an\n C<\/jats:styled-content>\n hinese population as has been suggested by previous publications.\n <\/jats:p>\n <\/jats:sec>\n \n Patients Subjects and Methods<\/jats:title>\n \n A case\u2010control study involving 466 patients with hypospadias and 402 healthy subjects was conducted to assess the relationship between\n DGKK<\/jats:styled-content>\n single nucleotide polymorphisms (\n SNP<\/jats:styled-content>\n s) and hypospadias risk in the\n H<\/jats:styled-content>\n an\n C<\/jats:styled-content>\n hinese population. The 466 hypospadias patients were further divided into mild, moderate and severe subgroups for analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Six\n SNPs<\/jats:styled-content>\n (rs1934179, rs4143304, rs9969978, rs1934188, rs4826632 and rs4599945) were marginally associated with mild and moderate hypospadias [odds ratios (\n OR<\/jats:styled-content>\n s) > 1,\n P<\/jats:italic>\n = 0.05 to\n P<\/jats:italic>\n < 0.1), whereas no significant relationship was seen with the severe cases (\n OR<\/jats:styled-content>\n s >1,\n P<\/jats:italic>\n > 0.1). After correcting for multiple testing, it was determined that neither individual\n SNP<\/jats:styled-content>\n s nor individual haplotypes were associated with hypospadias. To evaluate this relationship in multiple populations, we performed a meta\u2010analysis on six\n SNP<\/jats:styled-content>\n s, using combined data from our present results and those of previous studies of different races (including 1966 patients and 2492 controls). Six\n SNP<\/jats:styled-content>\n s (rs1934179, rs4143304, rs9969978, rs1934188, rs7063116 and rs1934190) were significantly associated with mild\/moderate hypospadias (\n OR<\/jats:styled-content>\n s >1,\n P<\/jats:italic>\n < 0.05), and rs1934179 was significantly associated with severe hypospadias (\n OR<\/jats:styled-content>\n > 1,\n P<\/jats:italic>\n < 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n DGKK<\/jats:styled-content>\n gene variants do not appear to play a major role in hypospadias susceptibility in the\n C<\/jats:styled-content>\n hinese\n H<\/jats:styled-content>\n an population. Our meta\u2010analysis supports the hypothesis that\n DGKK<\/jats:styled-content>\n is a common risk gene for hypospadias, particularly in cases of mild or moderate hypospadias in\n C<\/jats:styled-content>\n aucasian populations.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12965","type":"journal-article","created":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T07:34:20Z","timestamp":1413617660000},"page":"634-640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Diacylglycerol kinase \u03ba (\n DGKK<\/scp>\n ) variants and hypospadias in\n H<\/scp>\n an\n C<\/scp>\n hinese: association and meta\u2010analysis"],"prefix":"10.1111","volume":"116","author":[{"given":"Qichao","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Pediatric Urology Xinhua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunman","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houwei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Urology Xinhua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maosheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Urology Xinhua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Urology Xinhua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoliang","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Urology Xinhua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Bio\u2010X Institutes Ministry of Education Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Song","sequence":"additional","affiliation":[{"name":"Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Bio\u2010X Institutes Ministry of Education Shanghai Jiao Tong University Shanghai 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