{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:24:25Z","timestamp":1761765865988,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,7]],"date-time":"2015-03-07T00:00:00Z","timestamp":1425686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2015,9]]},"abstract":"\n Objective<\/jats:title>\n \n To investigate the risk of acute myocardial infarction (\n AMI<\/jats:styled-content>\n ) after androgen\u2010deprivation therapy (\n ADT<\/jats:styled-content>\n ) for prostate cancer in a Chinese population.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and methods<\/jats:title>\n \n All Chinese patients with prostate cancer who were treated primarily with radical prostatectomy or radiotherapy, with or without further\n ADT<\/jats:styled-content>\n at our hospital from the year 2000 to 2009 were retrospectively reviewed. We compared the risk of\n AMI<\/jats:styled-content>\n in the patients who were given further\n ADT<\/jats:styled-content>\n (\n ADT<\/jats:styled-content>\n group) with those who were not given any\n ADT<\/jats:styled-content>\n (non\u2010\n ADT<\/jats:styled-content>\n group). Potential risk factors of\n AMI<\/jats:styled-content>\n including age, diabetes mellitus, hypertension, hyperlipidaemia, history of stroke, ischaemic heart disease, Eastern Cooperative Oncology Group Performance Status (\n ECOG PS<\/jats:styled-content>\n ) and duration of\n ADT<\/jats:styled-content>\n were reviewed. The risk of\n AMI<\/jats:styled-content>\n after\n ADT<\/jats:styled-content>\n was first analysed using the Kaplan\u2013Meier method, followed by Cox regression analyses including the potential risk factors mentioned.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In all, 452 patients were included, with 200 patients in the non\u2010\n ADT<\/jats:styled-content>\n group and 252 patients in the\n ADT<\/jats:styled-content>\n group. The mean (\n sd<\/jats:sc>\n ) age was 68.2\u00a0(5.9)\u00a0years in the non\u2010\n ADT<\/jats:styled-content>\n group and 69.5\u00a0(6.5)\u00a0years in the\n ADT<\/jats:styled-content>\n group, and the difference was statistically significant (\n P<\/jats:italic>\n \u00a0=\u00a00.031). There were no significant differences in their pre\u2010existing medical conditions or\n ECOG PS<\/jats:styled-content>\n . The\n ADT<\/jats:styled-content>\n group was associated with an increased risk of\n AMI<\/jats:styled-content>\n when compared with the non\u2010\n ADT<\/jats:styled-content>\n group (\n P<\/jats:italic>\n \u00a0=\u00a00.004) upon Kaplan\u2010Meier analysis. Upon multivariate Cox regression analysis, hyperlipidaemia, poor\n ECOG PS<\/jats:styled-content>\n and the use of\n ADT<\/jats:styled-content>\n were the only three significant factors that were associated with increased risk of developing new\n AMI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n There was increased risk of\n AMI<\/jats:styled-content>\n after\n ADT<\/jats:styled-content>\n for prostate cancer in a Chinese population. Hyperlipidaemia and poor\n ECOG PS<\/jats:styled-content>\n were also significant risk factors for developing\n AMI<\/jats:styled-content>\n . The risk of\n AMI<\/jats:styled-content>\n should be considered when deciding on\n ADT<\/jats:styled-content>\n , especially in patients with history of hyperlipidaemia and relatively poor\n ECOG PS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12967","type":"journal-article","created":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T07:34:15Z","timestamp":1413617655000},"page":"382-387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Risk of acute myocardial infarction after androgen\u2010deprivation therapy for prostate cancer in a Chinese population"],"prefix":"10.1111","volume":"116","author":[{"given":"Jeremy Y.C.","family":"Teoh","sequence":"first","affiliation":[{"name":"Division of Urology Department of Surgery Prince of Wales Hospital The Chinese University of Hong Kong Shatin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samson Y.S.","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgery Prince of Wales Hospital The Chinese University of Hong Kong Shatin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter K.F.","family":"Chiu","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgery Prince of Wales Hospital The Chinese University of Hong Kong Shatin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren M.C.","family":"Poon","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Prince of Wales Hospital The Chinese University of Hong Kong Shatin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho\u2010Yuen","family":"Cheung","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgery North District Hospital Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon S.M.","family":"Hou","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgery Prince of Wales Hospital The Chinese University of Hong Kong Shatin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Fai","family":"Ng","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Surgery Prince of Wales Hospital The Chinese University of Hong Kong Shatin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(02)80307-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.1997.d01-6840.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.2.238"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.52.3.154"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.59.3.607"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70700-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09408-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20955"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2012.09.008"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.2497"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22933"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp404"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12732"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djm168"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.3.289"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1137"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.01.021"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.7423"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.9881"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.3752"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.0923"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.1494"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.01.047"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.108.005751"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.04.054"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.021121"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2011.02119.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.10.032"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbju.12967","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.12967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T17:25:30Z","timestamp":1761758730000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.12967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,7]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/bju.12967"],"URL":"https:\/\/doi.org\/10.1111\/bju.12967","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"type":"print","value":"1464-4096"},{"type":"electronic","value":"1464-410X"}],"subject":[],"published":{"date-parts":[[2015,3,7]]},"assertion":[{"value":"2015-03-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}