{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T23:37:53Z","timestamp":1781480273067,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,3,7]],"date-time":"2015-03-07T00:00:00Z","timestamp":1425686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2015,8]]},"abstract":"\n Objectives<\/jats:title>\n \n To report the first clinical experience with a temporary implantable nitinol device (\n TIND<\/jats:styled-content>\n ; Medi\u2010Tate\n \u00ae<\/jats:sup>\n ) for the treatment of lower urinary tract symptoms (\n LUTS<\/jats:styled-content>\n ) due to benign prostatic hyperplasia (\n BPH<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n In all, 32 patients with\n LUTS<\/jats:styled-content>\n were enrolled in this prospective study, which was approved by our Institutional Ethics Committee. Inclusion criteria were: age >50\u00a0years, International Prostate Symptom Score (\n IPSS<\/jats:styled-content>\n ) of \u226510, maximum urinary flow rate (Q\n max<\/jats:sub>\n ) of \u226412\u00a0mL\/s, and prostate volume of <60\u00a0mL. The\n TIND<\/jats:styled-content>\n was implanted within the bladder neck and the prostatic urethra under light sedation, using a rigid cystoscope. The device was removed 5\u00a0days later in an outpatient setting. Demographics, perioperative results, complications (according to the Clavien system), functional results and quality of life (QoL) were evaluated. Follow\u2010up assessments were made at 3 and 6\u00a0weeks, and 3, 6 and 12\u00a0months postoperatively. The Student's\n t\u2010<\/jats:italic>\n test, analysis of variance (\n anova<\/jats:sc>\n ), Kruskall\u2013Wallis test, and simple and multiple linear regression models were used in the statistical analyses.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The mean patient age was 69.4\u00a0years, the mean (standard deviation,\n sd<\/jats:sc>\n ) prostate volume was 29.5\u00a0(7.4)\u00a0mL and the Q\n max<\/jats:sub>\n was 7.6\u00a0(2.2)\u00a0mL\/s. The median (interquartile range,\n IQR<\/jats:styled-content>\n )\n IPSS<\/jats:styled-content>\n was 19\u00a0(14\u201323) and QoL score was 3\u00a0(3\u20134). All the implantations were successful, with no intraoperative complications recorded. The mean operative time (\n sd<\/jats:sc>\n ) was 5.8\u00a0(2.5)\u00a0min and the median (\n IQR<\/jats:styled-content>\n ) postoperative stay was 1\u00a0(1\u20132)\u00a0day. All but one of the devices (96%) was removed 5\u00a0days at after implantation in an outpatient setting. Four complications (12.5%) were recorded, including urinary retention (one, 3.1%), transient incontinence due to device displacement (one, 3.1%), prostatic abscess (one, 3.1%), and urinary tract infection (one, 3.1%). Multiple regression analysis failed to identify any independent prognostic factor for complications. There were statistically significant differences in the\n IPSS<\/jats:styled-content>\n , QoL score and Q\n max<\/jats:sub>\n when comparing pre\u2010 and postoperative results at every time point. After 12\u00a0months, the median (\n IQR<\/jats:styled-content>\n )\n IPSS<\/jats:styled-content>\n and QoL score were 9\u00a0(7\u201313) and 1\u00a0(1\u20132), respectively, and the mean (\n sd<\/jats:sc>\n ) Q\n max<\/jats:sub>\n was 12\u00a0(4.7)\u00a0mL\/s. The mean variations with respect to baseline conditions at the same time points were \u221245% for the\n IPSS<\/jats:styled-content>\n and +67% for Q\n max<\/jats:sub>\n . At 12\u00a0months after surgery (last follow\u2010up visit), no patients required medical therapy or surgical procedures for BPH.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n TIND<\/jats:styled-content>\n implantation is a feasible and safe minimally invasive option for the treatment of\n BPH<\/jats:styled-content>\n \u2010related\n LUTS<\/jats:styled-content>\n . The functional results are encouraging and the treatment significantly improved patient QoL. Further studies are required to assess durability of\n TIND<\/jats:styled-content>\n results and to optimise the indications of such a procedure.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.12982","type":"journal-article","created":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T04:52:01Z","timestamp":1415595121000},"page":"278-287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Temporary implantable nitinol device (\n TIND<\/scp>\n ): a novel, minimally invasive treatment for relief of lower urinary tract symptoms (\n LUTS<\/scp>\n ) related to benign prostatic hyperplasia (\n BPH<\/scp>\n ): feasibility, safety and functional results at 1\u00a0year of follow\u2010up"],"prefix":"10.1111","volume":"116","author":[{"given":"Francesco","family":"Porpiglia","sequence":"first","affiliation":[{"name":"S.C.D.U. Urologia Department of Oncology School of Medicine \u2018San Luigi Gonzaga\u2019 Hospital University of Turin Orbassano (Turin) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Fiori","sequence":"additional","affiliation":[{"name":"S.C.D.U. Urologia Department of Oncology School of Medicine \u2018San Luigi Gonzaga\u2019 Hospital University of Turin Orbassano (Turin) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Bertolo","sequence":"additional","affiliation":[{"name":"S.C.D.U. Urologia Department of Oncology School of Medicine \u2018San Luigi Gonzaga\u2019 Hospital University of Turin Orbassano (Turin) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diletta","family":"Garrou","sequence":"additional","affiliation":[{"name":"S.C.D.U. Urologia Department of Oncology School of Medicine \u2018San Luigi Gonzaga\u2019 Hospital University of Turin Orbassano (Turin) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"S.C.D.U. Urologia Department of Oncology School of Medicine \u2018San Luigi Gonzaga\u2019 Hospital University of Turin Orbassano (Turin) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Amparore","sequence":"additional","affiliation":[{"name":"S.C.D.U. 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