{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:00:22Z","timestamp":1778871622520,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T00:00:00Z","timestamp":1433894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>To assess the efficacy and safety of transperineal template\u2010guided prostate biopsy.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>From December 2003 to December 2013, a total of 3\u00a0007 patients (30\u201391\u00a0years old, mean age 69.1) who met the inclusion criteria underwent 11\u2010region transrectal ultrasound\u2010guided transperineal template prostate biopsy.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            The inclusion criteria included a prostate\u2010specific antigen (\n                            <jats:styled-content style=\"fixed-case\">PSA<\/jats:styled-content>\n                            ) level of 4.0\u00a0ng\/mL or greater and abnormal prostate gland findings on digital rectal examination, ultrasound,\n                            <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                            or\n                            <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                            . The median\n                            <jats:styled-content style=\"fixed-case\">PSA<\/jats:styled-content>\n                            level was 11.0\u00a0ng\/mL (range 0.2\u2013100\u00a0ng\/mL).\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The prostate cancer detection rate and prostate biopsy adverse effects, as well as prostate cancer spatial distribution were analyzed.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>A mean of 19.3 cores (range 11\u201344) were obtained for each biopsy, and more cores were obtained in larger prostates than in smaller ones.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            One to four cores were collected from each region. Prostate cancer was detected in 1\u00a0067 of the 3\u00a0007 patients (35.5%). The prostate cancer detection rates in groups with\n                            <jats:styled-content style=\"fixed-case\">PSA<\/jats:styled-content>\n                            levels of 0\u20134.0\u00a0ng\/mL, 4.1\u201310.0\u00a0ng\/mL, 10.1\u201320.0\u00a0ng\/mL, 20.1\u201350.0\u00a0ng\/mL, and 50.1\u2013100.0\u00a0ng\/mL were 15.3% (27\/176), 21.0% (248\/1\u00a0179), 32.6% (318\/975), 56.0% (232\/414), and 92.0% (241\/262), respectively.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            The mean positives for cancer in regions 1\u201310 and region 11 (the apical region) were 46.7% vs 52.0% (\n                            <jats:italic>P<\/jats:italic>\n                            = 0.014).\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Regarding adverse effects, 47.0% of the patients reported hematuria, 6.1% developed hemospermia, 1.9% required short\u2010term catheterization after biopsy because of acute urinary retention, and 0.03% (one patient) developed urosepsis.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Transrectal ultrasound\u2010guided transperineal template prostate biopsy is safe and accurate.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>The current study suggests that prostate carcinoma foci are more frequently localized in the apical region.<\/jats:p>\n   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