{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:59:09Z","timestamp":1785509949620,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T00:00:00Z","timestamp":1429488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To report pre\u2010specified and exploratory results on the effect of different surgical approaches on erectile function (\n                      <jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>\n                      ) after nerve\u2010sparing radical prostatectomy (ns\n                      <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content>\n                      ) obtained from the multicentre, randomised, double\u2010blind, double\u2010dummy\n                      <jats:styled-content style=\"fixed-case\">REACTT<\/jats:styled-content>\n                      trial of tadalafil (once a day [OaD] or on\u2010demand [\n                      <jats:italic>pro\u2010re\u2010nata<\/jats:italic>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">PRN<\/jats:styled-content>\n                      ]) vs placebo.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Patients aged &lt;68\u00a0years with normal preoperative EF who underwent nsRP for localised prostate cancer (Gleason \u22647, prostate\u2010specific antigen [PSA] &lt;10\u00a0ng\/mL) were randomised after nsRP 1:1:1 to 9\u2010month double\u2010blind treatment with tadalafil 5\u00a0mg OaD, tadalafil 20\u00a0mg PRN, or placebo, followed by 6\u2010week drug\u2010free washout, and 3\u2010month open\u2010label OaD treatment (all patients). Recovery of EF was defined as an International Index of Erectile Function (IIEF)\u2010EF domain score of \u226522 and normal orgasmic function was defined based on IIEF Question 10. Both parameters were analysed at the end of washout using logistic regression including terms for treatment, country, visit, visit\u2010by\u2010treatment interaction, age group, nerve\u2010sparing score (perfect = 2, non\u2010perfect &gt;2), and surgical approach (open surgery, robot\u2010assisted laparoscopy, conventional laparoscopy, other). Time to EF recovery was analysed\n                      <jats:italic>post hoc<\/jats:italic>\n                      with a Cox proportional\u2010hazards model including terms for treatment, age\u2010group, country, surgical approach and surgery\u2010by\u2010treatment interaction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 422 patients treated, 189 underwent open surgery, 115 robot\u2010assisted laparoscopy, 88 conventional laparoscopy and 30 surgery classified as \u2018other\u2019. The odds of achieving\n                      <jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>\n                      recovery at the end of drug\u2010free washout were about twice as high for the robot\u2010assisted laparoscopy group compared with the open surgery group (odds ratio 2.42; 95% confidence interval [\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ] 1.24, 4.72;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.029). Patients who underwent robot\u2010assisted laparoscopy were significantly more likely to recover during double\u2010blind treatment compared with patients who underwent open surgery (hazard ratio 1.92; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.17, 3.15;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.010). No favourable effect of conventional laparoscopy compared with open surgery could be seen.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These results may provide further insights into the role of surgery on\n                      <jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>\n                      recovery after ns\n                      <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content>\n                      . However, the trial was not designed for these analyses and further prospective studies are needed.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.13030","type":"journal-article","created":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T06:22:50Z","timestamp":1420438970000},"page":"241-251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Effect of surgical approach on erectile function recovery following bilateral nerve\u2010sparing radical prostatectomy: an evaluation utilising data from a randomised, double\u2010blind, double\u2010dummy multicentre trial of tadalafil vs placebo"],"prefix":"10.1111","volume":"116","author":[{"given":"Jens\u2010Uwe","family":"Stolzenburg","sequence":"first","affiliation":[{"name":"Department of Urology University Hospital Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Graefen","sequence":"additional","affiliation":[{"name":"Martini Hospital, UKE GmbH Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kriegel","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospital Leipzig Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Michl","sequence":"additional","affiliation":[{"name":"Martini Hospital, UKE GmbH Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Martin Morales","sequence":"additional","affiliation":[{"name":"Malaga Institute of Urology Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Pommerville","sequence":"additional","affiliation":[{"name":"Department of Urological Sciences University of British Columbia Victoria BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Manning","sequence":"additional","affiliation":[{"name":"Lilly Deutschland GmbH Bad Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartwig","family":"B\u00fcttner","sequence":"additional","affiliation":[{"name":"Lilly Deutschland GmbH Bad Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Henneges","sequence":"additional","affiliation":[{"name":"Lilly Deutschland GmbH Bad Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schostak","sequence":"additional","affiliation":[{"name":"Department of Urology and Paediatric Urology Magdeburg University Medical Centre Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.04.046"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.04.047"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.05.046"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0302-2838(03)00215-X"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.3.354"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12228"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01845.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10757.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2011.02237.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10402.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.08.019"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.10.028"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.10.118"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.09.051"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2007.00600.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00238-0"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10504.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.02179.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01972.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.11.049"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","unstructured":"BuffiN GallinaA GaddaGet\u00a0al.Predicting factors for erectile function recovery following intrafascial bilateral nerve\u2010sparing radical prostatectomy. 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