{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:52:22Z","timestamp":1790707942379,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"S6","license":[{"start":{"date-parts":[[2015,4,19]],"date-time":"2015-04-19T00:00:00Z","timestamp":1429401600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerische Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["127477"],"award-info":[{"award-number":["127477"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2015,4]]},"abstract":"\n Objectives<\/jats:title>\n \n To investigate feasibility, reproducibility and age dependency of sensory evoked cortical potentials (\n SEPs<\/jats:styled-content>\n ) after electrical stimulation of different locations in the lower urinary tract (\n LUT<\/jats:styled-content>\n ) in a cohort of middle\u2010aged healthy women.\n <\/jats:p>\n <\/jats:sec>\n \n Subjects and Methods<\/jats:title>\n \n In a group of 10 healthy middle\u2010aged women [mean (\n sd<\/jats:sc>\n ) height 165 (5) cm and age 43 (6) years), electrical stimulation (0.5 and 3\u2009Hz) was applied to the bladder dome, trigone, and proximal and distal urethra.\n SEPs<\/jats:styled-content>\n were recorded at the\n Cz<\/jats:styled-content>\n electrode with reference to\n Fz<\/jats:styled-content>\n . All measurements were repeated three times with an interval of 3\u20135 weeks. Current perception thresholds (\n CPT<\/jats:styled-content>\n ),\n SEP<\/jats:styled-content>\n latencies and amplitudes were analysed. Results were compared with a group of younger women published previously.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n LUT SEPs<\/jats:styled-content>\n demonstrated two positive (\n P1<\/jats:styled-content>\n ,\n P2<\/jats:styled-content>\n ) and one negative peak (\n N<\/jats:styled-content>\n 1). The mean (\n sd<\/jats:sc>\n )\n N1<\/jats:styled-content>\n latency was 108.9 (7.8), 116.2 (10.7), 113.2 (13.4) and 131.3 (35.6) ms for the bladder dome, trigone, proximal and distal urethra, respectively.\n N1<\/jats:styled-content>\n latencies, except for the distal urethra, were significantly shorter than those in younger women. Taking all data, i.e. young and middle\u2010aged women, into account, there was a significant negative correlation between the variable age and\n CPT<\/jats:styled-content>\n \/dome (\n r<\/jats:italic>\n = \u22120.462,\n P<\/jats:italic>\n = 0.04) and\n N1<\/jats:styled-content>\n latency\/dome (\n r<\/jats:italic>\n = \u22120.605,\n P<\/jats:italic>\n = 0.005) and a significant positive correlation between the variable age and\n N1P2<\/jats:styled-content>\n amplitude\/dome (\n r<\/jats:italic>\n = 0.542,\n P<\/jats:italic>\n = 0.014).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n LUT SEPs<\/jats:styled-content>\n can be induced in middle\u2010aged women with reliable\n N1<\/jats:styled-content>\n responses. Unexpectedly,\n N1<\/jats:styled-content>\n responses reveal a shortening with increasing age particularly when compared with younger women. Changes in sensory afferents may be explained by age\u2010related qualitative reorganisations within the urothelium and suburothelium potentially altering afferent nerve excitability, which may have an impact on the development of non\u2010neurological\n LUT<\/jats:styled-content>\n symptoms (LUTS, e.g. overactive bladder) in women.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.13066","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T04:53:37Z","timestamp":1422420817000},"page":"18-25","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Sensory evoked potentials of the bladder and urethra in middle\u2010aged women: the effect of age"],"prefix":"10.1111","volume":"115","author":[{"given":"Flavia","family":"Gregorini","sequence":"first","affiliation":[{"name":"Department of Neuro\u2010Urology Spinal Cord Injury Centre and Research University of Z\u00fcrich Balgrist University Hospital Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie C.","family":"Kn\u00fcpfer","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Urology Spinal Cord Injury Centre and Research University of Z\u00fcrich Balgrist University Hospital Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina D.","family":"Liechti","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Urology Spinal Cord Injury Centre and Research University of Z\u00fcrich Balgrist University Hospital Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schubert","sequence":"additional","affiliation":[{"name":"Department of Neurology Spinal Cord Injury Centre and Research University of Z\u00fcrich Balgrist University Hospital Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Curt","sequence":"additional","affiliation":[{"name":"Department of Neurology Spinal Cord Injury Centre and Research University of Z\u00fcrich Balgrist University Hospital Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Kessler","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Urology Spinal Cord Injury Centre and Research University of Z\u00fcrich Balgrist University Hospital Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Mehnert","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Urology Spinal Cord Injury Centre and Research University of Z\u00fcrich Balgrist University Hospital Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08371.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2005.05889.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09993.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.11.040"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2009.06.096"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20487"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)01544-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2008.03.016"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.11.151"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.09.019"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(02)00094-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199702)20:2<198::AID-MUS10>3.0.CO;2-#"},{"key":"e_1_2_7_14_1","first-page":"3","article-title":"The ten\u2010twenty electrode system of the International Federation. 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