{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:39:51Z","timestamp":1790707191512,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T00:00:00Z","timestamp":1429574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To assess the utility of routine frozen section analysis of ureters at the time of radical cystectomy (\n                      <jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content>\n                      ) for urothelial cancer (\n                      <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>\n                      ), and the long\u2010term outcomes of adverse ureteric pathology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Pathological data on 2\u00a0047 patients undergoing\n                      <jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content>\n                      for\n                      <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>\n                      with routine frozen section analysis of ureters (January 1971 to December 2009) were analysed. Univariate and multivariable logistic and Cox proportional hazards models were used to determine the risk of upper tract\n                      <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">UTUC<\/jats:styled-content>\n                      ) recurrence, local recurrence and overall survival in those identified as having adverse pathology (severe atypia\/carcinoma\n                      <jats:italic>in\u00a0situ<\/jats:italic>\n                      [\n                      <jats:styled-content style=\"fixed-case\">CIS<\/jats:styled-content>\n                      ] or\n                      <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>\n                      ) at time of frozen section analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Adverse pathology was identified by frozen section analysis in 178 patients (8.6%). Frozen section analysis was found to have poor sensitivity in identifying adverse pathology (59.1%), which was improved in patients with preoperative\n                      <jats:styled-content style=\"fixed-case\">CIS<\/jats:styled-content>\n                      (68.0%). After a median (interquartile range) follow\u2010up of 12.4 (1.9\u201310.1) years, 28 patients (1.4%) developed\n                      <jats:styled-content style=\"fixed-case\">UTUC<\/jats:styled-content>\n                      recurrence. There were no uretero\u2010enteric anastomotic recurrences. Adverse pathology on frozen section analysis was associated with\n                      <jats:styled-content style=\"fixed-case\">UTUC<\/jats:styled-content>\n                      recurrence on univariate analysis (hazard ratio [\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      ] 6.2, 95% confidence interval [\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ] 2.9\u201313.5), but 15\/28 patients (54%) with\n                      <jats:styled-content style=\"fixed-case\">UTUC<\/jats:styled-content>\n                      recurrence had benign ureteric frozen section analysis on initial sectioning. Adverse pathology on frozen section analysis was not independently associated with the risk of local recurrence (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      1.08, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      0.61\u20131.89) or overall survival (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      1.12, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      0.94\u20131.35) in multivariate models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Ureteric frozen section analysis has poor sensitivity and may be marginally improved in pre\u2010existing\n                      <jats:styled-content style=\"fixed-case\">CIS<\/jats:styled-content>\n                      .\n                      <jats:styled-content style=\"fixed-case\">UTUC<\/jats:styled-content>\n                      recurrence is rare and can occur despite negative frozen section analysis. Our data question the utility of routine frozen section analysis of the distal ureteric margin at the time of\n                      <jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.13081","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T22:49:00Z","timestamp":1423867740000},"page":"463-468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Utility and significance of ureteric frozen section analysis during radical cystectomy"],"prefix":"10.1111","volume":"117","author":[{"given":"Raj","family":"Satkunasivam","sequence":"first","affiliation":[{"name":"USC Institute of Urology and Norris Comprehensive Cancer Center Keck School of Medicine of USC Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Hu","sequence":"additional","affiliation":[{"name":"USC Institute of Urology and Norris Comprehensive Cancer Center Keck School of Medicine of USC Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Metcalfe","sequence":"additional","affiliation":[{"name":"USC Institute of Urology and Norris Comprehensive Cancer Center Keck School of Medicine of USC Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saum B.","family":"Ghodoussipour","sequence":"additional","affiliation":[{"name":"USC Institute of Urology and Norris Comprehensive Cancer Center Keck School of Medicine of USC Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju","family":"Aron","sequence":"additional","affiliation":[{"name":"Department of Pathology Norris Comprehensive Cancer Center Keck School of Medicine of USC Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Cai","sequence":"additional","affiliation":[{"name":"USC Institute of Urology and Norris Comprehensive Cancer Center Keck School of Medicine of USC Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gus","family":"Miranda","sequence":"additional","affiliation":[{"name":"USC Institute of Urology and Norris Comprehensive Cancer Center Keck School of Medicine of USC Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inderbir","family":"Gill","sequence":"additional","affiliation":[{"name":"USC Institute of Urology and Norris Comprehensive Cancer Center Keck School of Medicine of USC Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siamak","family":"Daneshmand","sequence":"additional","affiliation":[{"name":"USC Institute of Urology and Norris Comprehensive Cancer Center Keck School of Medicine of USC Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199203123261104"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.08.017"},{"issue":"3","key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/S0022-5347(01)64312-X","article-title":"Ureteral carcinoma in\u00a0situ at radical cystectomy: does the margin matter?","volume":"158","author":"Silver DA","year":"1997","journal-title":"J Urol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22238"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000092928"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.08.158"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-010-0581-z"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)63097-0"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)66223-2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)59579-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(89)90127-1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-014-1306-5"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpuro1210"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.08107"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12344"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.07.162"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)59645-7"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2004.04981.x"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbju.13081","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.13081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:18:37Z","timestamp":1761743917000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.13081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,21]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/bju.13081"],"URL":"https:\/\/doi.org\/10.1111\/bju.13081","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,21]]},"assertion":[{"value":"2015-04-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}