{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:57:41Z","timestamp":1779919061131,"version":"3.53.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,24]],"date-time":"2015-05-24T00:00:00Z","timestamp":1432425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Federal Ministry of Education and Research, Germany","award":["13N11308"],"award-info":[{"award-number":["13N11308"]}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To generate real\u2010time radio\u2010telemetric urodynamic reference data of maximum detrusor pressure (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>det\u00a0max<\/jats:sub>\n                      ), maximum flow rate (\n                      <jats:italic>Q<\/jats:italic>\n                      <jats:sub>max)<\/jats:sub>\n                      and estimated grade of infravesical obstruction, as well as duration of detrusor contraction (\n                      <jats:styled-content style=\"fixed-case\">DOC<\/jats:styled-content>\n                      ), in female G\u00f6ttingen minipigs and to describe translational aspects of the use of G\u00f6ttingen minipigs for urological research.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A telemetric transmitter was implanted into five female G\u00f6ttingen minipigs, and 24\u00a0h measurements in metabolic cages were taken. Through operator\u2010based analysis, synchronized real\u2010time radio\u2010telemetric cystometric data with flowmetric data and video sequences were used to determine voiding detrusor contractions (\n                      <jats:styled-content style=\"fixed-case\">VC<\/jats:styled-content>\n                      s) and non\u2010voiding detrusor contractions (\n                      <jats:styled-content style=\"fixed-case\">NVC<\/jats:styled-content>\n                      s). Furthermore, data from telemetric natural\u2010filling cystometry from free\u2010moving and restricted maintenance conditions were compared for potential differences.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median (range)\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>det\u00a0max<\/jats:sub>\n                      of\n                      <jats:styled-content style=\"fixed-case\">VC<\/jats:styled-content>\n                      s was 120.6 (21.0\u2013370.0) cmH\n                      <jats:sub>2<\/jats:sub>\n                      O and, therefore, significantly different from that of\n                      <jats:styled-content style=\"fixed-case\">NVC<\/jats:styled-content>\n                      s (64.60 [20.4\u2013280.6 cmH\n                      <jats:sub>2<\/jats:sub>\n                      O] cm H\n                      <jats:sub>2<\/jats:sub>\n                      O). Intraindividual comparison of minipig data revealed great differences in voiding contractions. The effects of limited movement on\n                      <jats:styled-content style=\"fixed-case\">VC<\/jats:styled-content>\n                      s were analysed and showed significantly higher\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>det\u00a0max<\/jats:sub>\n                      and lower\n                      <jats:styled-content style=\"fixed-case\">DOC<\/jats:styled-content>\n                      than in free\u2010moving conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The presented data can be used for the development of telecystometric implanted minipig models, to investigate changes of detrusor function such as under\u2010 or overactivity, and might serve as model for bladder changes occurring with iatrogenic bladder outlet obstruction (\n                      <jats:styled-content style=\"fixed-case\">BOO<\/jats:styled-content>\n                      ) or different therapeutic options for overactive bladder. Radio\u2010telemetric real\u2010time natural filling and voiding cystometries are feasible, reproducible in non\u2010anaesthetized minipigs with free or limited movement and can give new insights into circadian behaviour and physiological and pathological bladder function.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.13089","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T23:01:45Z","timestamp":1423868505000},"page":"823-832","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Telemetric monitoring of bladder function in female G\u00f6ttingen minipigs"],"prefix":"10.1111","volume":"116","author":[{"given":"Nadine D.","family":"Huppertz","sequence":"first","affiliation":[{"name":"Department of Urology University Hospital RWTH Aachen University Aachen 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