{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:46Z","timestamp":1787013946021,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T00:00:00Z","timestamp":1440720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2015,10]]},"abstract":"\n Objectives<\/jats:title>\n \n To characterise clinicopathological characteristics of prostate cancer among human immunodeficiency virus (\n HIV<\/jats:styled-content>\n )\u2010positive men and to evaluate the current practice patterns in the management of prostate cancer in these men.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n We retrospectively reviewed all patients with\n HIV<\/jats:styled-content>\n in the\n S<\/jats:styled-content>\n tate\u2010wide\n HIV<\/jats:styled-content>\n referral centre in\n V<\/jats:styled-content>\n ictoria, who were diagnosed with prostate cancer from 2000 onwards. In all, 12 patients were identified, and the medical records were reviewed to collect data on\n HIV<\/jats:styled-content>\n parameters at the time of prostate cancer diagnosis, as well as prostate cancer clinicopathological characteristics, treatment details and outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n At the time of prostate cancer diagnosis, eight patients had undetectable viral load, and the median cluster of differentiation 4 (\n CD4<\/jats:styled-content>\n ) count was 485 cells\/\u03bcL. The average age at diagnosis of prostate cancer was 63 years and the median prostate\u2010specific antigen (\n PSA<\/jats:styled-content>\n ) level of 11.1\u2009ng\/mL. Four patients had Gleason 6 prostate cancer, four Gleason 7, one Gleason 8 and three\n G<\/jats:styled-content>\n leason 9. Seven of the 12 patients had a positive family history for prostate cancer. Of the patients with clinically localised prostate cancer (10), most were treated with radiotherapy (\n RT<\/jats:styled-content>\n ): one permanent seed brachytherapy (BT), five external beam\n RT<\/jats:styled-content>\n (\n EBRT<\/jats:styled-content>\n ), two open radical prostatectomies (RP), one active surveillance (AS), and one on watchful waiting (WW). For the two patients with metastatic disease, one had androgen\u2010deprivation therapy and\n EBRT<\/jats:styled-content>\n , while the other had a combination of\n EBRT<\/jats:styled-content>\n and chemo\u2010hormonal therapy with doxetacel. All patients were followed for a median of 46 months, with three deaths reported, none of which was a prostate cancer\u2010specific death.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This is the first\n A<\/jats:styled-content>\n ustralasian series on prostate cancer management in a\n HIV<\/jats:styled-content>\n population. With the prolonged survival among\n HIV<\/jats:styled-content>\n \u2010positive men in the highly active anti\u2010retroviral therapy era,\n PSA<\/jats:styled-content>\n testing should be offered to this group of patients, especially those with a positive family history.\n HIV<\/jats:styled-content>\n \u2010positive men should also be offered all treatment options in the same manner as men in the general population.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.13097","type":"journal-article","created":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T08:48:49Z","timestamp":1440751729000},"page":"5-10","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinicopathological characteristics and management of prostate cancer in the human immunodeficiency virus (\n HIV<\/scp>\n )\u2010positive population: experience in an\n A<\/scp>\n ustralian major\n HIV<\/scp>\n centre"],"prefix":"10.1111","volume":"116","author":[{"given":"Wee Loon","family":"Ong","sequence":"first","affiliation":[{"name":"Department of Urology Alfred Health Melbourne Vic Australia"},{"name":"Departments of Epidemiology and Prevention Medicine Monash University Melbourne Vic Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Manohar","sequence":"additional","affiliation":[{"name":"Department of Urology Alfred Health Melbourne Vic Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Millar","sequence":"additional","affiliation":[{"name":"William Buckland Radiation Oncology Service Alfred Health Melbourne Vic Australia"},{"name":"Departments of Epidemiology and Prevention Medicine Monash University Melbourne Vic Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Royce","sequence":"additional","affiliation":[{"name":"Department of Urology Alfred Health Melbourne Vic Australia"},{"name":"Surgery Monash University Melbourne Vic 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