{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T18:13:33Z","timestamp":1784139213014,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T00:00:00Z","timestamp":1431302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To evaluate the effect of the interval between the initial and second transurethral resection (\n                      <jats:styled-content style=\"fixed-case\">TUR<\/jats:styled-content>\n                      ) on the outcome of patients with high\u2010risk non\u2010muscle\u2010invasive bladder cancer (\n                      <jats:styled-content style=\"fixed-case\">NMIBC<\/jats:styled-content>\n                      ) treated with maintenance intravesical Bacillus Calmette\u2010Gu\u00e9rin (\n                      <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>\n                      ) therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      We reviewed the data of patients from 10 centres treated for high\u2010risk\n                      <jats:styled-content style=\"fixed-case\">NMIBC<\/jats:styled-content>\n                      between 2005 and 2012. Patients without a diagnosis of muscle\u2010invasive cancer on second\n                      <jats:styled-content style=\"fixed-case\">TUR<\/jats:styled-content>\n                      performed \u226490\u00a0days after a complete first\n                      <jats:styled-content style=\"fixed-case\">TUR<\/jats:styled-content>\n                      , and received at least 1\u00a0year of maintenance\n                      <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>\n                      were included in this study. The interval between first and second\n                      <jats:styled-content style=\"fixed-case\">TUR<\/jats:styled-content>\n                      in addition to other parameters were recorded. Multivariate logistic regression analysis was used to identify predictors of recurrence and progression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In all, 242 patients were included. The mean (\n                      <jats:sc>sd<\/jats:sc>\n                      , range) follow\u2010up was 29.4 (22.2, 12\u201396)\u00a0months. The 3\u2010year recurrence\u2010 and progression\u2010free survival rates of patients who underwent second\n                      <jats:styled-content style=\"fixed-case\">TUR<\/jats:styled-content>\n                      between 14 and 42\u00a0days and 43\u201390\u00a0days were 73.6% vs 46.2% (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) and 89.1% vs 79.1% (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.006), respectively. On multivariate analysis, the interval to second\n                      <jats:styled-content style=\"fixed-case\">TUR<\/jats:styled-content>\n                      was found to be a predictor of both recurrence [odds ratio (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      ) 3.598, 95% confidence interval (\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ) 1.885\u20138.137;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001] and progression (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      2.144, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.447\u20135.137;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The interval between first and second\n                      <jats:styled-content style=\"fixed-case\">TUR<\/jats:styled-content>\n                      should be \u226442\u00a0days in order to attain lower recurrence and progression rates. To our knowledge, this is the first study demonstrating the effect of the interval between first and second\n                      <jats:styled-content style=\"fixed-case\">TUR<\/jats:styled-content>\n                      on patient outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.13102","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T12:02:14Z","timestamp":1424779334000},"page":"721-726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Significance of the interval between first and second transurethral resection on recurrence and progression rates in patients with high\u2010risk non\u2010muscle\u2010invasive bladder cancer treated with maintenance intravesical Bacillus Calmette\u2010Gu\u00e9rin"],"prefix":"10.1111","volume":"116","author":[{"given":"S\u00fcmer","family":"Baltac\u0131","sequence":"first","affiliation":[{"name":"Department of Urology Ankara University School of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Bozlu","sequence":"additional","affiliation":[{"name":"Department of Urology University of Mersin School of Medicine Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"As\u0131f","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[{"name":"Department of Urology \u0130stanbul Medeniyet University School of Medicine \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet \u0130lker","family":"G\u00f6k\u00e7e","sequence":"additional","affiliation":[{"name":"Department of Urology Ankara University School of Medicine Ankara 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