{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T01:42:17Z","timestamp":1769737337377,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate the long\u2010term oncological and functional outcomes of re\u2010adaptation of the dorsolateral peritoneal layer after pelvic lymph node dissection (\n                      <jats:styled-content style=\"fixed-case\">PLND<\/jats:styled-content>\n                      ) and cystectomy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      A randomized, single\u2010centre, single\u2010blinded, two\u2010arm trial was conducted on 200 consecutive patients who underwent\n                      <jats:styled-content style=\"fixed-case\">PLND<\/jats:styled-content>\n                      and cystectomy for bladder cancer (&lt;\n                      <jats:styled-content style=\"fixed-case\">cT<\/jats:styled-content>\n                      4,\n                      <jats:styled-content style=\"fixed-case\">cN<\/jats:styled-content>\n                      0,\n                      <jats:styled-content style=\"fixed-case\">cM<\/jats:styled-content>\n                      0) between April 2006 and September 2009. Patients were randomized into two groups: group A with re\u2010adaptation of the dorsolateral peritoneal layer (\n                      <jats:italic>n<\/jats:italic>\n                      = 100; 73 male, 27 female; median [range] age 68 [35\u201386] years) and group B without re\u2010adapation (\n                      <jats:italic>n<\/jats:italic>\n                      = 100; 66 male, 34 female; median [range] age 65 [30\u201386] years). Regular postoperative follow\u2010up was performed at our outpatient clinic. The median follow\u2010up was 59 (3\u2013100) months. Five patients were lost to follow\u2010up in group A and seven in group B. Bowel function was evaluated using the validated Gastrointestinal Quality of Life Index questionnaire and an institutional questionnaire regarding post\u2010cystectomy outcome. Local recurrences and distal metastases were evaluated using computed tomography and bone scan at the regular follow\u2010up visits.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was no significant difference between the two groups in terms of the rate of local (pelvic) recurrence (5\/95 [5.3%] in group A; 7\/93 [7.5%] in group B;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.53), the rate of distant metastases (21\/95 [22.1%] in group A; 23\/93 [24.7%] in group B;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.67), cancer\u2010specific survival (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.37) or overall survival (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.59). Group A had significantly better bowel function at 3 (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), 6 (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.006), 12 (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.006) and 24\u00a0months (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.04), and significantly less postoperative abdominal pain and bloating at 3 (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.002) and 6\u00a0months (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Re\u2010adaptation of the dorsolateral peritoneal layer after\n                      <jats:styled-content style=\"fixed-case\">PLND<\/jats:styled-content>\n                      and cystectomy has a beneficial long\u2010term impact on bowel function and postoperative pain without compromising oncological radicality.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.13178","type":"journal-article","created":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T21:43:14Z","timestamp":1431121394000},"page":"618-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Long\u2010term results of a prospective randomized trial assessing the impact of re\u2010adaptation of the dorsolateral peritoneal layer after extended pelvic lymph node dissection and cystectomy"],"prefix":"10.1111","volume":"117","author":[{"given":"Mihai Dorin","family":"Vartolomei","sequence":"first","affiliation":[{"name":"Department of Urology University of Bern Bern Switzerland"},{"name":"Department of Cell and Molecular Biology University of Medicine and Pharmacy Targu Mures Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Kiss","sequence":"additional","affiliation":[{"name":"Department of Urology University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro","family":"Vidal","sequence":"additional","affiliation":[{"name":"Department of Urology University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Burkhard","sequence":"additional","affiliation":[{"name":"Department of Urology University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George N.","family":"Thalmann","sequence":"additional","affiliation":[{"name":"Department of Urology University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beat","family":"Roth","sequence":"additional","affiliation":[{"name":"Department of Urology University of Bern Bern 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