{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T08:25:58Z","timestamp":1768638358073,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,7,18]],"date-time":"2015-07-18T00:00:00Z","timestamp":1437177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Doctors Hospital at Renaissance Distinguished University Chair in Urology"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2016,5]]},"abstract":"\n Objective<\/jats:title>\n To assess the 1\u2010year renal functional changes in patients undergoing partial nephrectomy with intra\u2010operative renal biopsies.<\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n A total of 40 patients with a single renal mass deemed fit for a partial nephrectomy were recruited prospectively between January 2009 and October 2010. We performed renal biopsies of normal renal parenchyma and collected serum markers before, during and after surgically induced renal clamp ischaemia during the partial nephrectomy. We then followed patients clinically with interval serum creatinine and physical examination.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Peri\u2010operative data from 40 patients showed a transient increase in creatinine levels which did not correlate with ischaemia time. Renal ultrastructural changes were generally mild and included mitochondrial swelling, which resolved at the post\u2010perfusion biopsy. A total of 37 patients had 1\u2010year follow\u2010up data. Creatinine at 1\u00a0year increased by 0.121\u00a0mg\/\n dL<\/jats:styled-content>\n , which represents a 12.99% decrease in renal function from baseline (preoperative creatinine 0.823\u00a0mg\/\n dL<\/jats:styled-content>\n , estimated glomerular filtration rate = 93.9 mL\/min\/1.73 m\n 2<\/jats:sup>\n ). The only factors predicting creatinine change on multivariate analysis were patient age, race and ischaemia type, with cold ischaemia being associated with higher creatinine level. Importantly, the duration of ischaemia did not show any significant correlation with renal function change, either as a continuous variable (\n P<\/jats:italic>\n = 0.452) or as a categorical variable (\n P<\/jats:italic>\n = 0.792).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Our data suggest that limited ischaemia is generally well tolerated in the setting of partial nephrectomy and does not directly correspond to long\u2010term renal functional decline. For surgeons performing partial nephrectomy, the kidney can be safely clamped to ensure optimum oncological outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.13192","type":"journal-article","created":{"date-parts":[[2015,6,6]],"date-time":"2015-06-06T03:53:04Z","timestamp":1433562784000},"page":"766-774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Long\u2010term response to renal ischaemia in the human kidney after partial nephrectomy: results from a prospective clinical trial"],"prefix":"10.1111","volume":"117","author":[{"given":"George J.S.","family":"Kallingal","sequence":"first","affiliation":[{"name":"Department of Urology University of Miami Miller School of Medicine Miami Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel M.","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine University of Michigan and Veterans Affairs Ann Arbor Healthcare System and University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isildinha M.","family":"Reis","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences University of Miami Miller School of Medicine Miami Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avinash","family":"Nehra","sequence":"additional","affiliation":[{"name":"Department of Urology University of Miami Miller School of Medicine Miami Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjeri A.","family":"Venkatachalam","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas Health Science Center San Antonio San Antonio TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipen J.","family":"Parekh","sequence":"additional","affiliation":[{"name":"Department of Urology University of Miami Miller School of Medicine Miami Miami FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.10.146"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.08.040"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012080786"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041031"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70803-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.09.036"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.05.047"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.03.042"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000138158.16968.8d"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2004.04.019"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.08.036"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.12.068"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.09.030"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.09.131"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-014-1315-4"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.34.520"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.11.121"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbju.13192","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.13192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:27:45Z","timestamp":1761748065000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.13192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,18]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/bju.13192"],"URL":"https:\/\/doi.org\/10.1111\/bju.13192","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,18]]},"assertion":[{"value":"2015-07-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}