{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:43:10Z","timestamp":1787240590232,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,8,22]],"date-time":"2015-08-22T00:00:00Z","timestamp":1440201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007605","name":"Aarhus University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007605","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2016,7]]},"abstract":"\n Objectives<\/jats:title>\n \n To estimate the diagnostic accuracy of sentinel node biopsy (\n SNB<\/jats:styled-content>\n ) combined with preoperative\n 18<\/jats:sup>\n F\u2010fluorodeoxyglucose positron emission tomography\/computed tomography (\n FDG PET<\/jats:styled-content>\n \/\n CT<\/jats:styled-content>\n ) for inguinal lymph node (\n LN<\/jats:styled-content>\n ) evaluation in patients with invasive penile squamous cell carcinoma (\n PSCC<\/jats:styled-content>\n ) with no clinical evidence of inguinal metastases (\n cN<\/jats:styled-content>\n 0) at two tertiary centres with complete clinical follow\u2010up.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n From April 2010 in Centre one and from January 2013 in Centre two, we prospectively enrolled patients diagnosed with invasive\n PSCC<\/jats:styled-content>\n and scheduled for\n SNB<\/jats:styled-content>\n at the only two university centres treating penile cancer in Denmark. All patients had\n FDG PET<\/jats:styled-content>\n \/\n CT<\/jats:styled-content>\n before\n SNB<\/jats:styled-content>\n . The sentinel\n LN<\/jats:styled-content>\n s were preoperatively located by planar lymphoscintigraphy in 134 groins (68 patients) and by single\u2010photon emission\n CT<\/jats:styled-content>\n \/\n CT<\/jats:styled-content>\n in 120 groins (61 patients). The primary endpoints were the sensitivity, specificity, and false\u2010negative rate of\n SNB<\/jats:styled-content>\n combined with\n FDG PET<\/jats:styled-content>\n \/\n CT<\/jats:styled-content>\n . The secondary endpoint was\n SNB<\/jats:styled-content>\n \u2010related morbidity.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We examined 254 groins in 129 patients by\n SNB<\/jats:styled-content>\n combined with\n FDG PET<\/jats:styled-content>\n \/\n CT<\/jats:styled-content>\n . The median (interquartile range,\n IQR<\/jats:styled-content>\n ) follow\u2010up of survivors was 23 (14\u201335)\u00a0months. Of 201\n LN<\/jats:styled-content>\n \u2010negative groins, two were false negatives, and despite radio\u2010chemotherapy treatment, both patients died from penile cancer. Four of 23 radiotracer\u2010silent groins, had a\n FDG PET<\/jats:styled-content>\n \/\n CT<\/jats:styled-content>\n \u2010positive\n LN<\/jats:styled-content>\n s and were surgically explored. In one of four of the explored groins, a positive\n LN<\/jats:styled-content>\n was found. Combined\n FDG PET<\/jats:styled-content>\n \/\n CT<\/jats:styled-content>\n \u2010\n SNB<\/jats:styled-content>\n sensitivity was 94.4% (95% confidence interval [\n CI<\/jats:styled-content>\n ] 81\u201399%) per groin. The false\u2010negative rate was 5.6% (95%\n CI<\/jats:styled-content>\n 1\u201319%) per groin. In 15 patients (11.6%) there were 25\n SNB<\/jats:styled-content>\n \u2010related complications of Clavien\u2013Dindo grades I\u2013\n III<\/jats:styled-content>\n a. The only Clavien\u2013Dindo\n III<\/jats:styled-content>\n a complication was an inguinal lymphocele treated by aspiration.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In this study, we present a favourable\n SNB<\/jats:styled-content>\n false\u2010negative rate of 5.6% in a national cohort of clinically\n LN<\/jats:styled-content>\n \u2010negative patients with invasive\n PSCC<\/jats:styled-content>\n with a pre\u2010\n SNB FDG PET<\/jats:styled-content>\n \/\n CT<\/jats:styled-content>\n scan. The combination of\n FDG PET<\/jats:styled-content>\n \/\n CT<\/jats:styled-content>\n and\n SNB<\/jats:styled-content>\n seems to be a promising diagnostic approach. Even so, a false\u2010negative\n SNB<\/jats:styled-content>\n was fatal in two of two cases and we are determined to continue the development of our\n SNB<\/jats:styled-content>\n technique. The\n SNB<\/jats:styled-content>\n \u2010related morbidity was limited.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.13243","type":"journal-article","created":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T03:15:04Z","timestamp":1438053304000},"page":"102-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["DaPeCa\u20103: promising results of sentinel node biopsy combined with\n 18<\/sup>\n F\u2010fluorodeoxyglucose positron emission tomography\/computed tomography in clinically lymph node\u2010negative patients with penile cancer \u2013 a national study from Denmark"],"prefix":"10.1111","volume":"118","author":[{"given":"Jakob K.","family":"Jakobsen","sequence":"first","affiliation":[{"name":"Department of Urology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Alslev","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology Nuclear Medicine and PET Copenhagen University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Ipsen","sequence":"additional","affiliation":[{"name":"Department of Radiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junia C.","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology Nuclear Medicine and PET Copenhagen University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim P.","family":"Krarup","sequence":"additional","affiliation":[{"name":"Department of Urology Copenhagen University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Sommer","sequence":"additional","affiliation":[{"name":"Department of Urology Copenhagen University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Nerstr\u00f8m","sequence":"additional","affiliation":[{"name":"Department of Urology Copenhagen University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte G.","family":"Toft","sequence":"additional","affiliation":[{"name":"Department of Pathology Rigshospitalet Copenhagen University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"H\u00f8yer","sequence":"additional","affiliation":[{"name":"Department of Pathology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Bouchelouche","sequence":"additional","affiliation":[{"name":"Nuclear\u00a0Medicine and PET\u2010Centre Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen B.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Urology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.02.021"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.10.060"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2001.00379.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13127"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/21681805.2014.987316"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mnm.0000134329.30912.49"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.6126"},{"key":"e_1_2_7_9_1","unstructured":"MillerRT.Cytokeratin AE1\/AE3. 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