{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:32:22Z","timestamp":1785191542256,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T00:00:00Z","timestamp":1446422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2016,8]]},"abstract":"\n Objectives<\/jats:title>\n \n To compare outcomes of renal transplantation (\n RT<\/jats:styled-content>\n x) in children with end\u2010stage renal disease (\n ESRD<\/jats:styled-content>\n ) resulting from lower urinary tract dysfunction (\n LUTD<\/jats:styled-content>\n ) vs other causes.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n A database of children (<18 years old) who underwent\n RT<\/jats:styled-content>\n x between May 2008 and April 2012 was reviewed. Patients were divided into those with\n LUTD<\/jats:styled-content>\n (group A,\n n<\/jats:italic>\n = 29) and those with other causes of\n ESRD<\/jats:styled-content>\n (group B,\n n<\/jats:italic>\n = 74).\n RT<\/jats:styled-content>\n x was performed after achieving low intravesical pressure (<30 cmH\n 2<\/jats:sub>\n O) with adequate bladder capacity and drainage. The groups were compared using Student's\n t\u2010<\/jats:italic>\n test, Mann\u2013Whitney, chi\u2010squared or exact tests. Graft survival rates (\n GSR<\/jats:styled-content>\n s) were evaluated using Kaplan\u2013Meier curves and the log\u2010rank test.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The mean \u00b1\n sd<\/jats:sc>\n (range) age of the study cohort was 5.05 \u00b1 12.4 (2.2\u201318) years. Causes of\n LUTD<\/jats:styled-content>\n were posterior urethral valve (\n PUV<\/jats:styled-content>\n ; 41.4%), vesico\u2010ureteric reflux (\n VUR<\/jats:styled-content>\n ; 37.9%), neurogenic bladder (10.3%), prune belly syndrome (3.4%), obstructive megaureter (3.4%) and urethral stricture disease (3.4%). There was no significant difference in age, dialysis duration or donor type. In group A, 25 of the 29 patients (86.2%) underwent \u22651 surgery to optimize the urinary tract for allograft. Pretransplant nephrectomy was performed in 15 of the 29 patients (51.7%),\n PUV<\/jats:styled-content>\n ablation in nine patients (31%) and ileocystoplasty in four patients (13.7%). The mean \u00b1\n sd<\/jats:sc>\n follow\u2010up was 4.52 \u00b1 1.55 and 4.07 \u00b1 1.27 years in groups A and B, respectively. There was no significant difference in creatinine and\n eGFR<\/jats:styled-content>\n between the groups at different points of follow\u2010up. The\n GSR<\/jats:styled-content>\n s at the end of the study were 93.1 and 91.1% in groups A and B, respectively (\n P<\/jats:italic>\n = 1.00). According to Kaplan\u2013Meier survival curves, there was no significant difference in the\n GSR<\/jats:styled-content>\n between the groups using the log\u2010rank test (\n P<\/jats:italic>\n = 0.503). No graft was lost as a result of urological complications. In group B, one child died from septicaemia. The rate of urinary tract infections was 24 and 12% in groups A and B, respectively, but was not significant. No significant difference was found between the groups with regard to the incidence of post\u2010transplantation hydronephrosis. Of the 22 patients who had hydronephrosis after transplantation, three were complicated by\n UTI<\/jats:styled-content>\n . Injection of bulking agents was required in two patients for treatment of grade 3\n VUR<\/jats:styled-content>\n . In the third patient, augmentation cystoplasty was needed.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Acceptable graft function, survival and\n UTI<\/jats:styled-content>\n rates can be achieved in children with\n ESRD<\/jats:styled-content>\n attributable to\n LUTD<\/jats:styled-content>\n . Thorough assessment and optimization of\n LUT<\/jats:styled-content>\n , together with close follow\u2010up, are key for successful\n RT<\/jats:styled-content>\n x.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.13347","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T06:32:55Z","timestamp":1444026775000},"page":"320-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Outcomes of living donor renal transplantation in children with lower urinary tract dysfunction: a comparative retrospective study"],"prefix":"10.1111","volume":"118","author":[{"given":"Ismail R.","family":"Saad","sequence":"first","affiliation":[{"name":"Department of Urology Kasr Al\u2010Ainy Hospitals Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enmar","family":"Habib","sequence":"additional","affiliation":[{"name":"Department of Urology Kasr Al\u2010Ainy Hospitals Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed S.","family":"ElSheemy","sequence":"additional","affiliation":[{"name":"Department of Urology Kasr Al\u2010Ainy Hospitals Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Abdel\u2010Hakim","sequence":"additional","affiliation":[{"name":"Department of Urology Kasr Al\u2010Ainy Hospitals Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Sheba","sequence":"additional","affiliation":[{"name":"Department of Urology Kasr Al\u2010Ainy Hospitals Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziz","family":"Mosleh","sequence":"additional","affiliation":[{"name":"Department of Urology Kasr Al\u2010Ainy Hospitals Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doaa 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