{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:35:38Z","timestamp":1789713338336,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine if a re\u2010transurethral resection (TUR), in the presence or absence of muscle at the first TUR in patients with T1\u2010high grade (HG)\/Grade 3 (G3) bladder cancer, makes a difference in recurrence, progression, cancer specific (CSS) and overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>In a large retrospective multicentre cohort of 2451 patients with T1\u2010HG\/G3 initially treated with bacille Calmette\u2013Gu\u00e9rin, 935 (38%) had a re\u2010TUR. According to the presence or absence of muscle in the specimen of the primary TUR, patients were divided in four groups: group 1 (no muscle, no re\u2010TUR), group 2 (no muscle, re\u2010TUR), group 3 (muscle, no re\u2010TUR) and group 4 (muscle, re\u2010TUR). Clinical outcomes were compared across the four groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Re\u2010TUR had a positive impact on recurrence, progression, CSS and OS only if muscle was not present in the primary TUR specimen. Adjusting for the most important prognostic factors, re\u2010TUR in the absence of muscle had a borderline significant effect on time to recurrence [hazard ratio (HR) 0.67,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.08], progression (HR 0.46,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.06), CSS (HR 0.31,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.07) and OS (HR 0.48,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.05). Re\u2010TUR in the presence of muscle in the primary TUR specimen did not improve the outcome for any of the endpoints.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our retrospective analysis suggests that re\u2010TUR may not be necessary in patients with T1\u2010HG\/G3, if muscle is present in the specimen of the primary TUR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.13354","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T11:41:48Z","timestamp":1444909308000},"page":"44-52","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":133,"title":["The impact of re\u2010transurethral resection on clinical outcomes in a large multicentre cohort of patients with T1 high\u2010grade\/Grade 3 bladder cancer treated with bacille Calmette\u2013Gu\u00e9rin"],"prefix":"10.1111","volume":"118","author":[{"given":"Paolo","family":"Gontero","sequence":"first","affiliation":[{"name":"Urology Clinic Citt\u00e0 della Salute e della Scienza di Torino University of Studies of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Sylvester","sequence":"additional","affiliation":[{"name":"Formerly Department of Biostatistics EORTC Headquarters Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Pisano","sequence":"additional","affiliation":[{"name":"Urology Clinic Citt\u00e0 della Salute e della Scienza di Torino University of Studies of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Joniau","sequence":"additional","affiliation":[{"name":"Oncologic and Reconstructive Urology Department of Urology University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Oderda","sequence":"additional","affiliation":[{"name":"Urology Clinic Citt\u00e0 della Salute e della Scienza di Torino University of Studies of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Serretta","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Stomatological Sciences University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Larr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Surgical Science John Radcliffe Hospital University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savino","family":"Di Stasi","sequence":"additional","affiliation":[{"name":"Policlinico Tor Vergata\u2010University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bas","family":"Van Rhijn","sequence":"additional","affiliation":[{"name":"Department of Urology Netherlands Cancer Institute \u2013 Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred J.","family":"Witjes","sequence":"additional","affiliation":[{"name":"Department of Urology Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne J.","family":"Grotenhuis","sequence":"additional","affiliation":[{"name":"Department of Urology Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzo","family":"Colombo","sequence":"additional","affiliation":[{"name":"Dipartimento di Urologia Universit\u00e0 Vita\u2010Salute. Ospedale S. Raffaele Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Briganti","sequence":"additional","affiliation":[{"name":"Dipartimento di Urologia Universit\u00e0 Vita\u2010Salute. Ospedale S. Raffaele Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Babjuk","sequence":"additional","affiliation":[{"name":"Department of Urology Motol Hospital University of Praha Praha Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Soukup","sequence":"additional","affiliation":[{"name":"Department of Urology Motol Hospital University of Praha Praha Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per\u2010Uno","family":"Malmstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Urology Academic Hospital Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Irani","sequence":"additional","affiliation":[{"name":"Department of Urology Centre Hospitalier Universitaire La Mil\u00e9trie University of Poitiers Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Malats","sequence":"additional","affiliation":[{"name":"Genetic and Molecular Epidemiology Group Spanish National Cancer Research Centre (CNIO) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Baniel","sequence":"additional","affiliation":[{"name":"Department of Urology Rabin Medical Centre Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Mano","sequence":"additional","affiliation":[{"name":"Department of Urology Rabin Medical Centre Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Urology Santa Chiara Hospital Trento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene K.","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Urology Weill Medical College of Cornell University in New York City New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ardelt","sequence":"additional","affiliation":[{"name":"Facharzt fur Urologie Abteilung fur Urologie. 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