{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:48:51Z","timestamp":1779342531934,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,27]],"date-time":"2015-12-27T00:00:00Z","timestamp":1451174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate the relevance of C\u2010reactive protein (\n                      <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                      ) and squamous cell carcinoma antigen (\n                      <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>\n                      \u2010Ag) levels in relation to clinicopathological factors and prognosis in penile cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      A total of 124 Chinese patients with penile squamous cell carcinoma (\n                      <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>\n                      ), treated between November 2007 and October 2014, were analysed retrospectively. Receiver\u2010operating characteristic curves were used to identify the combination of markers with the best sensitivity and specificity for prognosis prediction. Statistical data analysis was performed using a non\u2010parametric method, and survival analysis was performed using the log\u2010rank test and Cox proportional hazard model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Levels of\n                      <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                      \u22654.5 mg\/L and\n                      <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>\n                      \u2010Ag \u22651.4 ng\/\n                      <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\n                      were both significantly associated with lymph node metastasis (\n                      <jats:styled-content style=\"fixed-case\">LNM<\/jats:styled-content>\n                      ) laterality (chi\u2010squared trend test,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.041), extranodal extension (chi\u2010squared trend test,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), pelvic\n                      <jats:styled-content style=\"fixed-case\">LNM<\/jats:styled-content>\n                      (chi\u2010squared trend test,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.024), pathological tumour status (chi\u2010squared trend test,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.002), pathological nodal status (chi\u2010squared trend test,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), and disease\u2010specific survival (\n                      <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\n                      ; log\u2010rank test,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). Moreover, the influence of\n                      <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>\n                      \u2010Ag levels on\n                      <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.033, hazard ratio 3.390, 95% confidence interval 1.104\u201310.411) remained after adjusting for smoking history, phimosis, tumour status, tumour cell differentiation and nodal status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The present study shows that the combined measurement of preoperative\n                      <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>\n                      \u2010Ag levels may serve as an independent biomarker for\n                      <jats:styled-content style=\"fixed-case\">LNM<\/jats:styled-content>\n                      , advanced tumour stage and\n                      <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\n                      in patients with penile\n                      <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  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