{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:09:19Z","timestamp":1787317759532,"version":"build-2736575974"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T00:00:00Z","timestamp":1452556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To determine the outcome of clinically negative node (\n                      <jats:styled-content style=\"fixed-case\">cN<\/jats:styled-content>\n                      0) patients with penile cancer undergoing dynamic sentinel node biopsy (\n                      <jats:styled-content style=\"fixed-case\">DSNB<\/jats:styled-content>\n                      ), comparing the results of a 1\u2010 and 2\u2010day protocol that can be used as a minimal invasive procedure for staging of penile cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      This is a retrospective analysis of 151\n                      <jats:styled-content style=\"fixed-case\">cN<\/jats:styled-content>\n                      0 patients who underwent\n                      <jats:styled-content style=\"fixed-case\">DSNB<\/jats:styled-content>\n                      from 2008 to 2013 for newly diagnosed penile cancer. Data were analysed per groin and separated into groups according to the protocol followed. The comparison of the two protocols involved the number of nodes excised, \u03b3\u2010counts, false\u2010negative rates (\n                      <jats:styled-content style=\"fixed-case\">FNR<\/jats:styled-content>\n                      ), and complication rates (Clavien\u2013Dindo grading system).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In all, 280 groins from 151 patients underwent\n                      <jats:styled-content style=\"fixed-case\">DSNB<\/jats:styled-content>\n                      after a negative ultrasound \u00b1 fine\u2010needle aspiration cytology. The 1\u2010day protocol was performed in 65 groins and the 2\u2010day protocol in 215. Statistically significantly more nodes were harvested with the 1\u2010day protocol (1.92\/groin) compared with the 2\u2010day protocol (1.60\/groin). The\n                      <jats:styled-content style=\"fixed-case\">FNR<\/jats:styled-content>\n                      s were 0%, 6.8% and 5.1%, for the 1\u2010day protocol, 2\u2010day protocol, and overall, respectively. Morbidity of the\n                      <jats:styled-content style=\"fixed-case\">DSNB<\/jats:styled-content>\n                      was 21.4% for all groins, and 26.2% and 20.1% for the 1\u2010day and 2\u2010day protocols, respectively. Most of the complications were of Clavien\u2013Dindo Grade 1\u20132.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">DSNB<\/jats:styled-content>\n                      is safe for staging patients with penile cancer. There is a trend towards a 1\u2010day protocol having a lower\n                      <jats:styled-content style=\"fixed-case\">FNR<\/jats:styled-content>\n                      than a 2\u2010day protocol, albeit at the expense of a slightly higher complication rate.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.13389","type":"journal-article","created":{"date-parts":[[2015,12,8]],"date-time":"2015-12-08T22:13:26Z","timestamp":1449612806000},"page":"890-896","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Dynamic sentinel lymph node biopsy for penile cancer: a comparison between 1\u2010 and 2\u2010day protocols"],"prefix":"10.1111","volume":"117","author":[{"given":"Panagiotis","family":"Dimopoulos","sequence":"first","affiliation":[{"name":"Department of Urology The Christie Hospital Manchester 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