{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:12:12Z","timestamp":1762431132012,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,4,6]],"date-time":"2016-04-06T00:00:00Z","timestamp":1459900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["26861273"],"award-info":[{"award-number":["26861273"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2016,12]]},"abstract":"\n Objective<\/jats:title>\n \n To investigate the potential relationship of steroid usage with prostate\u2010specific antigen (\n PSA<\/jats:styled-content>\n ) flare as well as the prognostic impact of\n PSA<\/jats:styled-content>\n flare, which is known to occur in 10\u201320% of patients with metastatic castration\u2010resistant prostate cancer during docetaxel chemotherapy.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n This study included 71 patients with metastatic castration\u2010resistant prostate cancer treated by docetaxel chemotherapy with co\u2010introduction of a steroid.\n PSA<\/jats:styled-content>\n flare was defined as a transient\n PSA<\/jats:styled-content>\n increase followed by a\n PSA<\/jats:styled-content>\n decrease.\n <\/jats:p>\n <\/jats:sec>\n \n \n Result\n s<\/jats:bold>\n <\/jats:title>\n \n PSA<\/jats:styled-content>\n flare was recognized in 7.0\u201323.9% of patients according to the definition used. Intriguingly, men with steroid intake before the initiation of docetaxel chemotherapy experienced significantly fewer\n PSA<\/jats:styled-content>\n flares. The progression\u2010free survival rate in men with\n PSA<\/jats:styled-content>\n flare was equivalent to that of\n PSA<\/jats:styled-content>\n responders, but significantly better than men with\n PSA<\/jats:styled-content>\n failure.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Our results suggest that\n de novo<\/jats:italic>\n steroid co\u2010introduction with docetaxel chemotherapy induces the\n PSA<\/jats:styled-content>\n flare phenomenon. This novel finding may account for the mechanism of\n PSA<\/jats:styled-content>\n flare as well as being valuable for distinguishing\n PSA<\/jats:styled-content>\n elevation attributable to\n PSA<\/jats:styled-content>\n flare from that attributable to\n PSA<\/jats:styled-content>\n failure.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.13483","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T03:09:17Z","timestamp":1458356957000},"page":"880-884","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Co\u2010introduction of a steroid with docetaxel chemotherapy for metastatic castration\u2010resistant prostate cancer affects PSA flare"],"prefix":"10.1111","volume":"118","author":[{"given":"Masaki","family":"Shiota","sequence":"first","affiliation":[{"name":"Department of Urology Graduate School of Medical Sciences Kyushu University Fukuoka 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