{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:02:46Z","timestamp":1767981766520,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,23]],"date-time":"2016-04-23T00:00:00Z","timestamp":1461369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2016,11]]},"abstract":"\n Objective<\/jats:title>\n \n To assess the role of oral pentosan polysulphate (\n PPS<\/jats:styled-content>\n ) in the reduction of bacille Calmette\u2010Gu\u00e9rin (\n BCG<\/jats:styled-content>\n )\u2010related local side effects in patients with high grade Ta\/T1 non\u2010muscle\u2010invasive bladder cancer (\n NMIBC<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n A total of 32 symptomatic patients receiving\n BCG<\/jats:styled-content>\n instillation were randomized into three groups: group A received placebo (vitamin B complex tablet) thrice daily; group B received\n PPS<\/jats:styled-content>\n 100\u00a0mg thrice daily; and group C received\n PPS<\/jats:styled-content>\n 100\u00a0mg once daily and placebo (vitamin B complex tablet) twice daily for 6\u00a0weeks. A visual analogue scale (\n VAS<\/jats:styled-content>\n ) score for bladder pain, Overactive Bladder\u2010Validated 8 Question Screener (\n OAB<\/jats:styled-content>\n \u2010V8) scores and dysuria were evaluated in the three groups before and during each weekly visit for\n BCG<\/jats:styled-content>\n instillation.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The mean \u00b1\n sd<\/jats:sc>\n post\u2010treatment\n VAS<\/jats:styled-content>\n scores were significantly lower in groups B (4.4 \u00b1 1.2) and C (5.8 \u00b1 0.8) than in group A (8 \u00b1 0.4). In addition, the post\u2010treatment\n VAS<\/jats:styled-content>\n score was significantly lower in group B than in group C (\n P<\/jats:italic>\n <0.01). The mean post\u2010treatment\n OAB<\/jats:styled-content>\n \u2010V8 score was significantly lower only in group B (decreased from 15.5 to 9.7). Dysuria decreased in groups B and C but persisted in group A.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The present study shows that oral\n PPS<\/jats:styled-content>\n (100\u00a0mg) thrice daily is effective in relieving\n BCG<\/jats:styled-content>\n \u2010related local side effects.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bju.13489","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T06:52:54Z","timestamp":1458802374000},"page":"758-762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Role of oral pentosan polysulphate in the reduction of local side effects of BCG therapy in patients with non\u2010muscle\u2010invasive bladder cancer: a pilot study"],"prefix":"10.1111","volume":"118","author":[{"given":"Suresh","family":"Yadav","sequence":"first","affiliation":[{"name":"Department of Urology and Renal Transplantation S.M.S. Medical College and Hospital Jaipur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinay","family":"Tomar","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation S.M.S. Medical College and Hospital Jaipur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sher Singh","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation S.M.S. Medical College and Hospital Jaipur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivam","family":"Priyadarshi","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation S.M.S. Medical College and Hospital Jaipur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indraneel","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation S.M.S. Medical College and Hospital Jaipur India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.11.023"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.07.076"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64273-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67707-5"},{"key":"e_1_2_7_6_1","first-page":"766","article-title":"EORTC Genito\u2010Urinary Tract Cancer Group Long\u2010term efficacy results of EORTC genito\u2010urinary group randomized phase 3 study 30911 comparing intravesical instillations of epirubicin, bacillus Calmette\u2010Guerin and bacillus Calmette\u2010Guerin plus isoniazid in patients with intermediate and high risk stage Ta\u2013T1 urothelial carcinoma of the bladder","volume":"57","author":"Sylvester RJ","year":"2010","journal-title":"EurUrol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.04.104"},{"key":"e_1_2_7_8_1","first-page":"S21","article-title":"The role of pentosanpolysulphate in treatment approaches for interstitial cystitis","volume":"1","author":"Joel M.H","year":"2002","journal-title":"Rev Urol"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)39897-X"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(90)80116-5"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20543"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02850085"},{"key":"e_1_2_7_13_1","first-page":"462","article-title":"Final results of an EORTC\u2010GU cancer group randomized study of maintenance bacillus Calmette\u2010 Guerin in intermediate\u2010 and high\u2010risk Ta, T1 papillary carcinoma of the urinary bladder: one\u2010third dose versus full dose and 1 year versus 3 years maintenance","volume":"63","author":"Oddens J","year":"2013","journal-title":"EurUrol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2490-14-64"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66981-9"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0022-5347(17)53654-X","article-title":"Prevention of urinary tract infection by the exogenous glycosaminglycan sodium pentosanpolysulfate","volume":"127","author":"Parsons CL","year":"1982","journal-title":"J Urol"},{"key":"e_1_2_7_17_1","first-page":"211","article-title":"Macrophage interaction with mycobacteria including M. leprae","volume":"2","author":"Ryter A","year":"1984","journal-title":"Acta Leprol"},{"issue":"1","key":"e_1_2_7_18_1","first-page":"S21","article-title":"Teichman: the role of pentosanpolysulfate in treatment approaches for interstitial cystitis department of surgery, division of urology, university of texas health science center at San Antonio","volume":"4","author":"Joel MH","year":"2002","journal-title":"TX. Rev Urol"},{"key":"e_1_2_7_19_1","unstructured":"Janssen Pharmaceuticals: Elmiron_\u2010100 MG (Pentosan Polysulfate Sodium) Capsules Prescribing Information. Available at:http:\/\/www.orthoelmiron. com\/sites\/default\/files\/assets\/elmiron.pdf#zoom\u00bc100. Last accessed 11 December 2013"}],"container-title":["BJU International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbju.13489","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bju.13489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T07:52:04Z","timestamp":1761724324000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjui-journals.onlinelibrary.wiley.com\/doi\/10.1111\/bju.13489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,23]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/bju.13489"],"URL":"https:\/\/doi.org\/10.1111\/bju.13489","archive":["Portico"],"relation":{},"ISSN":["1464-4096","1464-410X"],"issn-type":[{"value":"1464-4096","type":"print"},{"value":"1464-410X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,23]]},"assertion":[{"value":"2016-04-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}