{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T01:15:17Z","timestamp":1776474917645,"version":"3.51.2"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T00:00:00Z","timestamp":1471478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate the efficacy and safety of continuous saline bladder irrigation (\n                      <jats:styled-content style=\"fixed-case\">CSBI<\/jats:styled-content>\n                      ) after transurethral resection of bladder tumour (\n                      <jats:styled-content style=\"fixed-case\">TURBT<\/jats:styled-content>\n                      ) in patients with low\u2010 to intermediate\u2010risk non\u2010muscle invasive bladder cancer (\n                      <jats:styled-content style=\"fixed-case\">NMIBC<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      In this prospective randomized study, 250 patients with primary low\u2010 to intermediate\u2010risk tumours were enrolled. Patients were randomly allocated to receive\n                      <jats:styled-content style=\"fixed-case\">CSBI<\/jats:styled-content>\n                      (2 000 mL\/h for the first 1 h, then 1 000 mL\/h for 2 h, followed by 500 mL\/h for 15 h) or a single immediate instillation of mitomycin C (\n                      <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content>\n                      ) after\n                      <jats:styled-content style=\"fixed-case\">TURBT<\/jats:styled-content>\n                      . The primary endpoint was recurrence\u2010free survival, and secondary endpoints were progression\u2010free survival and adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 227 patients (114 in the\n                      <jats:styled-content style=\"fixed-case\">CSBI<\/jats:styled-content>\n                      group and 113 in\n                      <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content>\n                      group) remained for analysis after exclusion criteria had been applied. The median follow\u2010up period was 37 months. No significant differences in patient characteristics were observed between the groups. The 5\u2010year recurrence\u2010free rates for\n                      <jats:styled-content style=\"fixed-case\">CSBI<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content>\n                      were 62.6% (95% confidence interval [\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ] 0.49\u20130.73) and 70.4% (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      0.59\u20130.78), respectively. Kaplan\u2013Meier analysis of recurrence\u2010free survival did not show any significant differences between the groups (log\u2010rank test\n                      <jats:italic>P<\/jats:italic>\n                      = 0.53). Furthermore, there were no significant differences between the groups in terms of tumour progression rate and the median time to first recurrence. The incidence of adverse events was significantly lower in the\n                      <jats:styled-content style=\"fixed-case\">CSBI<\/jats:styled-content>\n                      group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The results show that\n                      <jats:styled-content style=\"fixed-case\">CSBI<\/jats:styled-content>\n                      after\n                      <jats:styled-content style=\"fixed-case\">TURBT<\/jats:styled-content>\n                      may be a treatment option for patients with low\u2010 to intermediate\u2010risk\n                      <jats:styled-content style=\"fixed-case\">NMIBC<\/jats:styled-content>\n                      in terms of its prophylactic effect and safety.\n                    <\/jats:p>\n                  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