{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:48:40Z","timestamp":1777661320303,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T00:00:00Z","timestamp":1477612800000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001171","name":"NSW Cancer Institute","doi-asserted-by":"crossref","award":["10\/ECF\/2-29"],"award-info":[{"award-number":["10\/ECF\/2-29"]}],"id":[{"id":"10.13039\/501100001171","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Australian National Health and Medical Research Council Training Fellowship","award":["1016598"],"award-info":[{"award-number":["1016598"]}]}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To study the patterns of care of penile cancer diagnosed in the state of New South Wales (\n                      <jats:styled-content style=\"fixed-case\">NSW<\/jats:styled-content>\n                      ) over a 10\u00a0year period and determine factors that are associated with differences in survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      All invasive penile cancer diagnosed between 2001 and 2009 in\n                      <jats:styled-content style=\"fixed-case\">NSW<\/jats:styled-content>\n                      , Australia, were identified from the Central Cancer Registry. Records of treatment from the Admitted Patient Data Collection and deaths from the Registry of Births Deaths and Marriages were electronically linked. Predictors of receiving an inguinal lymph node dissection (\n                      <jats:styled-content style=\"fixed-case\">ILND<\/jats:styled-content>\n                      ) were analysed using multivariable logistic regression. Survival analyses were performed with Kaplan\u2010Meier and Cox proportional hazards models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 220 men were diagnosed with penile cancer over the 10\u00a0years from 69 centres. The median number of penile operations performed over 10\u00a0years was &lt;4. Radical penile surgery (partial or total penectomy) was performed in 70% of the cases and the proportion of patients receiving radical surgery increased over time (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.015). Only 53\/220 men with invasive penile cancer received an\n                      <jats:styled-content style=\"fixed-case\">ILND<\/jats:styled-content>\n                      . Younger age and higher stage were the only factors that predicted whether\n                      <jats:styled-content style=\"fixed-case\">ILND<\/jats:styled-content>\n                      was performed. Overall survival (\n                      <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                      ) was predicted by age, stage, marital status and co\u2010morbidity status. Low centre volume decreased\n                      <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                      by 37% (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      0.63 [95% CI: 0.40\u20130.97]). For men who received\n                      <jats:styled-content style=\"fixed-case\">ILND<\/jats:styled-content>\n                      , low centre volume decreased\n                      <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                      by 60% (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      0.40 [95% CI: 0.19\u20130.85]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      There is a decreasing trend for the use of conservative penile surgery and median centre volumes for penile cancer surgery in\n                      <jats:styled-content style=\"fixed-case\">NSW<\/jats:styled-content>\n                      are low. A decrease in overall survival is observed in men treated in lower volume surgery centres.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.13626","type":"journal-article","created":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T12:33:36Z","timestamp":1477658016000},"page":"35-42","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Volume\u2010outcome relationship in penile cancer treatment: a population based patterns of care and outcomes study from Australia"],"prefix":"10.1111","volume":"118","author":[{"given":"Manish I.","family":"Patel","sequence":"first","affiliation":[{"name":"Discipline of Surgery Westmead Hospital University of Sydney Sydney Australia"},{"name":"Department of Urology Westmead Hospital Westmead Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuigi","family":"Yuminaga","sequence":"additional","affiliation":[{"name":"Department of Urology Westmead Hospital Westmead Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Bang","sequence":"additional","affiliation":[{"name":"Cancer Research Division NSW Cancer Council Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Lawrentschuk","sequence":"additional","affiliation":[{"name":"University of Melbourne Department of Surgery\/Olivia Newton\u2010John Cancer Research Institute Austin Health and Department of Surgical Oncology Peter MacCallum Hospital Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Skyring","sequence":"additional","affiliation":[{"name":"Department of Urology Wollongong Hospital Wollongong Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David P.","family":"Smith","sequence":"additional","affiliation":[{"name":"Cancer Research Division NSW Cancer Council Sydney Australia"},{"name":"Sydney Medical School The University of Sydney Sydney Australia"},{"name":"Menzies Health Institute Queensland Griffith University Gold Coast Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.10.031"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365590050509913"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0456"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-011-9785-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.12.007"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-015-1191-4"},{"key":"e_1_2_7_8_1","unstructured":"National Institute for Clinical Excellence.Improving Outcomes in Urological Cancers.2002; Available at:https:\/\/www.nice.org.uk\/guidance\/csg2. 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