{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:27:10Z","timestamp":1790702830229,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,10,3]],"date-time":"2016-10-03T00:00:00Z","timestamp":1475452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bjui-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BJU International"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To investigate diagnostic accuracy of multiphase computed tomography urography (\n                      <jats:styled-content style=\"fixed-case\">MCTU<\/jats:styled-content>\n                      ) and visual assessment at ureterorenoscopy (\n                      <jats:styled-content style=\"fixed-case\">URS<\/jats:styled-content>\n                      ) for detection of upper tract urothelial carcinoma (\n                      <jats:styled-content style=\"fixed-case\">UTUC<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Consecutive patients referred to our tertiary care centre were included in a prospective study covering the period 2005 to 2012. The patients underwent initial imaging and\n                      <jats:styled-content style=\"fixed-case\">URS<\/jats:styled-content>\n                      with focal samples taken. Cytopathological results served as reference standard.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We investigated 174 renal units (\n                      <jats:styled-content style=\"fixed-case\">RU<\/jats:styled-content>\n                      s; renal pelvis and adjacent ureter) in 148 patients.\n                      <jats:styled-content style=\"fixed-case\">UTUC<\/jats:styled-content>\n                      was found in 104\n                      <jats:styled-content style=\"fixed-case\">RU<\/jats:styled-content>\n                      s.\n                      <jats:styled-content style=\"fixed-case\">MCTU<\/jats:styled-content>\n                      had an accuracy of 0.74, sensitivity of 0.89, specificity of 0.51, positive predictive value of 0.73, and negative predictive value of 0.75; corresponding values for\n                      <jats:styled-content style=\"fixed-case\">URS<\/jats:styled-content>\n                      were 0.84, 0.84, 0.85, 0.89, and 0.78, respectively.\n                      <jats:styled-content style=\"fixed-case\">MCTU<\/jats:styled-content>\n                      had significantly higher sensitivity and accuracy compared with other imaging techniques (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.05). Compared with\n                      <jats:styled-content style=\"fixed-case\">MCTU<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">URS<\/jats:styled-content>\n                      had similar sensitivity but significantly greater specificity and accuracy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Both\n                      <jats:styled-content style=\"fixed-case\">MCTU<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">URS<\/jats:styled-content>\n                      are important tools in the diagnostic evaluation of\n                      <jats:styled-content style=\"fixed-case\">UTUC<\/jats:styled-content>\n                      although neither of those techniques achieves 100% accuracy.\n                      <jats:styled-content style=\"fixed-case\">MCTU<\/jats:styled-content>\n                      should be chosen as the radiographical method if there are no contraindications and\n                      <jats:styled-content style=\"fixed-case\">URS<\/jats:styled-content>\n                      should always be combined with focal cytology and biopsies of suspicious lesions. To enhance diagnostic precision both\n                      <jats:styled-content style=\"fixed-case\">MCTU<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">URS<\/jats:styled-content>\n                      with focal samples should be included in the diagnostic procedure. The present results add impact to current diagnostic guidelines.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bju.13652","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T17:05:03Z","timestamp":1473440703000},"page":"289-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Diagnostic accuracy of computed tomography urography and visual assessment during ureterorenoscopy in upper tract urothelial carcinoma"],"prefix":"10.1111","volume":"119","author":[{"given":"Alexandra","family":"Grahn","sequence":"first","affiliation":[{"name":"Karolinska Institutet Department of Oncology and Pathology Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miden","family":"Melle\u2010Hannah","sequence":"additional","affiliation":[{"name":"Ryhov County Hospital Department of Urology J\u00f6nk\u00f6ping 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